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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Induction, recovery, and safcfy characteristics of scvoflurane in children underoing ambulatory surgery 显示文摘 | LEMAN J DAVIS P J WELBRON L G | 1996 | Anesthesiology1996，84，： | 1 |
| 3 | The properties of some magnesium-lithium alloys containing aluminum and zinc 显示文摘 | BUSK R S LEMAN D L CASEY J J | 1950 | Trails AIME1950，188，： | 1 |
| 4 | 显示文摘 | Bush R S Leman D L Casey J J | 1950 | Trans AIME1950，188，： | 1 |
| 5 | Per ceived and real barr iers formen ent ering nur sing: implications fo r gender div ersity显示文摘 | Roth J E Co leman C L | 2008 | J Cult Divers2008，15，3： | 1 |
| 6 | Carbonyl sulfide-mediated prebiotic formation of peptides显示文摘 | Leman L Orgel L E Ghadiri M | 2004 | Science2004，306，： | 1 |
| 7 | Factors that influence litter size in pigs显示文摘 | Clark L K Leman A D Morris R | 1986 | Pig News and Information1986，73，： | 1 |
| 8 | How potential users of music search and retrieval systems describe the semantic quality of music显示文摘 | Lesaffre M De Voogdt L Leman M | 2008 | Journal of the American Society for Information Science and Tectmology2008，59，5： | 1 |
| 9 | Current concepts review:the management of open rfactures显示文摘 | Gustilo R B Merkow R L Temp leman | 1990 | J Bone Joint Surg Am1990，72，2： | 1 |
| 10 | Statin effects be yond lipid lowering-are they clinically relevant?显示文摘 | Bonetti P O Leman L O Napoli C | 2003 | Eur Heart J2003，24，3： | 1 |
| 11 | Factors that influence litter size in pigs: Part 1 显示文摘 | Clark L K Leman A D | 1986 | Pig News and Information1986，7，3： | 1 |
| 12 | Factors that influence litter size in pigs: Part 2 显示文摘 | Clark L K Leman A D | 1986 | Pig News and Information1986，7，3： | 1 |
| 13 | Decline of hexachlorocyclohexane in the arctic atmosphere and reversal of air sea gas exchange显示文摘 | BID LEMAN T F JANTUNEN L M FALCONER R L | 1995 | Geophys Res Letters1995，，22： | 1 |
| 14 | The properties of some magnesium-lithium alloys containing aluminum and zinc 显示文摘 | Busk R S Leman D L Casey J J | 1950 | Journal of Metals1950，，7： | 1 |
| 15 | Applica tion of in vitro anthemintic sensitivity assays to canine parasi tology: Detecting resistance to pyrantel in Ancylostoma cani hum 显示文摘 | KOPP S R C()LEMAN G T MCCARTHY J S et a l | 2008 | Vet Parasitol2008，152，34： | 1 |
| 16 | Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers 显示文摘 | Leman E S Schoen R E Weissfeld J L | 2007 | Cancer Res2007，67，12： | 1 |
| 17 | Macrocyclic pep- toid-peptide hybrids as inhibitors of Class I histone deacetylases 显示文摘 | Olsen C A Montero A Leman L J | 2012 | ACS Med Chem Lett2012，3，9： | 1 |
| 18 | Endothelial dysfunction: a marker of atherosclerotic risk 显示文摘 | Boneti P O Leman L O Leman A | 2003 | Arterioscler Thromb Vasc Biol2003，23，16： | 1 |
| 19 | An embodied approach to testing musical empathy in participants with an autism spectrum disorder显示文摘 | De Bruyn L Moelants D Leman M | 2011 | Music and Medicine2011，4，1： | 1 |
| 20 | Greenhouse gas emissions from Chinese cities 显示文摘 | Sugar L Kennedy C Leman E | 2012 | Journal of Industrial Ecology2012，16，4： | 1 |
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