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144篇 您的检索式:作者名="Leire"
    题名 作者 年代 出处 被引量
1Epidermal stem cells and skin tissue engineering in hair follicle regeneration显示文摘The reconstitution of a fully organized and functional hair follicle from dissociated cells propagated under defined tissue culture conditions is a challenge stillpending in tissue engineering. The loss of hair follicles caused by injuries or pathologies such as alopecia not only affects the patients' psychological well-being, but also endangers certain inherent functions of the skin. It is then of great interest to find different strategies aiming to regenerate or neogenerate the hair follicle under conditions proper of an adult individual. Based upon current knowledge on the epithelial and dermal cells and their interactions during the embryonic hair generation and adult hair cycling, many researchers have tried to obtain mature hair follicles using different strategies and approaches depending on the causes of hair loss. This review summarizes current advances in the different experimental strategies to regenerate or neogenerate hair follicles, with emphasis on those involving neogenesis of hair follicles in adult individuals using isolated cells and tissue engineering. Most of these experiments were performed using rodent cells, particularly from embryonic or newborn origin. However, no successful strategy to generate human hair follicles from adult cells has yet been reported. This review identifies several issues that should be considered to achieve this objective. Perhaps the most important challenge is to provide threedimensional culture conditions mimicking the structure of living tissue. Improving culture conditions that allow the expansion of specific cells while protecting their inductive properties, as well as methods for selecting populations of epithelial stem cells, should give us the necessary tools to overcome the difficulties that constrain human hair follicle neogenesis. An analysis of patent trends shows that the number of patent applications aimed at hair follicle regeneration and neogenesis has been increasing during the last decade. This field is attractive not only to academic researchers but also to the companies that own almost half of the patents in this field.María Eugenia Balaná Hernán Eduardo Charreau Gustavo Jose Leirós 2015World Journal of Stem Cells2015,7,4:7
2Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus显示文摘Rahul Pannala Jeffery B. Leirness William R. Bamlet Ananda Basu Gloria M. Petersen Suresh T. Chari 2008Gastroenterology2008,,:2
3Forecasting rodent outbreaks in Africa: an ecological basis for Mastomys control in Tanzania显示文摘Leirs H Verhagen R Verheyen W 1996Journal of Applied Ecology1996,33,5:1
4Defining the validity of a biochemical index of soil quality显示文摘M. C. Leirós C. Trasar-Cepeda F. García-Fernández F. Gil-Sotres 1999Biology and Fertility of Soils (-)1999,,1:1
5On the economic benefit of predicting rodent outbreaks in agricultural systems 显示文摘Davis SA Leirs H Pech R 2004Crop Protection2004,23,4:1
6Transpedicular bone graftingas a supplement to posterior pedicle screw instrumentation in thora-columbar burst fractures 显示文摘Van Herck B Leirs G Van Loon J 2009Acta Orthop Belg2009,75,6:1
7Dependence of mineralization of soil organic matter on temperature and moisture显示文摘Leirós MC Trasar - Cepeda C Seoane S 1999Soil Biol Biochem1999,31,:1
8Blood pressure reduction after oral glucose loading and its relation to age blood pressure and insulin显示文摘JasenR W Penterman B J van Leir H J 1987Am J Cardio1987,60,13:1
9Transpedicular bone grafting as a supplement to posterior pedicle screw instrumentation in tho- racolumbar burst fractures显示文摘Van Herck B Leirs G Van Loon J 2009Acta Orthop Belg2009,75,6:1
10Fluctuating rodent populations and risk to humans from rodent-borne zoonoses显示文摘 Calvet E Leirs H 2005Vector-borne Dis2005,5,4:1
11Dependence of mineralization of soil organic matter on temperature and moisture 显示文摘Leirs M C Trasar-Cepeda C Seoane S 1999Soil Biology and Biochemistry1999,31,32:1
12Dependence of mineralization of soil organic matter on temperature and moisture显示文摘 Trasar-Cepeda C Seoane S 1999Soil Biology & Biochemistry1999,31,:1
13Transpedicular bone graft- ing as a supplement to posterior pedicle screw instru- mentation in tharamlunnlbar burst fracture显示文摘Van HB Leirs G Van LJ 2009Acta Orthop Belg2009,75,6:1
14Polymers containing phosphorus groups and polythers:Frum synthesis to appli- cation 显示文摘Smaranda Iliescu Leire Zubizarreta Nicoleta Plesu 2012Chemistry Central Journal2012,6,1:1
15Dependence of mineralization of soil organic matter on temperature and moisture显示文摘Leirós M C Trasar-Cepeda C Seoane S 1999Soil Biology & Biochemistry1999,31,:1
16Rationale for trimetazidine administration in myocardial ischaemia-reperfusion yndrome显示文摘De Leirs J Boucher F 1993Eur Heart J1993,14,:1
17Prevalence and clinical profile of pancreatic cancer-associated diabetes melli- tus 显示文摘Pannala R Leirness JB Bamlet WR 2008Gastroenterology2008,134,:1
18Transpedicular bone grafting as a supplement to posterior pedicle screw instrumentation inthoracolumbar burst fractures 显示文摘Van erck B Leirs G Van Loon J 2009Acta Orthop Belg2009,75,6:1
19Tumor suppression by collagen XV is independent of the restin domain显示文摘Mutolo MJ Morris KJ Leir SH 2012Matrix Biol2012,31,5:1
20The abundance threshold for plague as a critical percolation phenomenon 显示文摘Davis S Trapman P Leirs H 2005Nature2005,454,724:1
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