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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | A summary of European experience with shore nourishment显示文摘 | L Hamm M Capobianco H.H Dette A Lechuga R Spanhoff M.J.F Stive | 2002 | Coastal Engineering2002，，2： | 1 |
| 3 | Prevalence of undiagnosed atrial fibrillation and of that not being treated with anticoagulant drugs: the AFABE study 显示文摘 | Clua - Espuny JL Lechuga - Duran I Bosch - Princep R | 2013 | Rev Esp Cardio}2013，66，7： | 1 |
| 4 | Parameters of normalitity in multifrequency tympanometry显示文摘 | LECHUGA R FRADE C SOTO A | 2000 | Acta Otorrinolaringol Esp2000，51，： | 1 |
| 5 | Parameters of normality in multifrequency tympanometry 显示文摘 | LECHUGA R FRADE C SOTO A | 2000 | Acta Otorrinolaringol Esp2000，51，： | 1 |
| 6 | Analysis of the resonant frequency of the middle ear in otosclerosis显示文摘 | FRADE C LECHUGA R CASTRO C | 2000 | Acta Otorrinolaringol Esp2000，51，： | 1 |
| 7 | TGF-betal modulates matrix metalloproteinase-13 expression in hepatic stellate eells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k 显示文摘 | Lechuga C G Herna ndez-Nazara Z H JA D R | 2004 | American journal of physiology Gastrointesti- nal and liver physiology2004，287，5： | 1 |
| 8 | Beach nourishment projects, practices, and objectives—a European overview显示文摘 | H Hanson A Brampton M Capobianco H.H Dette L Hamm C Laustrup A Lechuga R Spanhoff | 2002 | Coastal Engineering2002，，2： | 1 |
| 9 | A summary of European experience with shore nourishment显示文摘 | L Hamm M Capobianco H.H Dette A Lechuga R Spanhoff M.J.F Stive | 2002 | Coastal Engineering2002，，2： | 1 |
| 10 | Analysis of the resonance frequency of the middle ear in otosclerosis 显示文摘 | Frade C Lechuga R Castro C Labella T | 2000 | Acta Otorrinolaringol Esp2000，51，4： | 1 |
| 11 | Endemic goiter in pregnant women:utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests显示文摘 | CASTANEDA R LECHUGA D RAMOS R I | 2002 | BJOG2002，109，12： | 1 |
| 12 | Analysis of the reso-nant frequency of the middle ear in otosclerosis显示文摘 | Frade C Lechuga R Castroc | 2000 | Acta otorrinolaringol Esp2000，51，： | 1 |
| 13 | Effect of Concentration on the Primary and Ultimate Biodegradation of Alkylpolyglucosides in Aerobic Biodegradation Tests显示文摘 | Jurado E Fernández-Serrano M Núnez-Olea J Lechuga M Jiménez J L Ríos F | 2011 | Water Environment Research2011，，2： | 1 |
| 14 | Central pontine and extrapontine myelinolysis:clinical case, brain magnetic resonance and evolution in 13 patients显示文摘 | L6pez-Send6n Moreno J Vera Lechuga R Est~vez Sant6 S | 2009 | Neurologia2009，24，3： | 1 |
| 15 | Effect of Concentration on the Primary and Ultimate Biodegradation of Alkylpolyglucosides in Aerobic Biodegradation Tests显示文摘 | Jurado E Fernández-Serrano M Núnez-Olea J Lechuga M Jiménez J L Ríos F | 2011 | Water Environment Research2011，，2： | 1 |
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