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| 1 | GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma显示文摘AIM: To evaluate the association between CYPIA1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinorna (ADC) in a high risk area of northwest of France.METHODS: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles, GSTM1 *2/*2 and GSl-l-l*2/*2 null genotypes). A total of 79 esophagealcancer cases and 130 controls were recruited. RESULTS: GSTM2*2/*2 and CYP1A1*1A/*2C genotype frequencies were higher among squamous cell cardnomas at a level close to statistical significance (OR = 1.83, 95% CI0.88-3.83, P= 0.11; OR = 3.03, 95% CI 0.93-9.90, P= 0.07,respectively). For GSTP1 polymorphism, no difference wasfound between controls and cases, whatever their histological status. Lower frequency of GST/-1 deletion was observed in ADC group compared to controls with a statistically significant difference (OR=13.31, 95% CI 1.66-106.92, P<0.01).CONCLUSION: In SCC, our results are consistent with the strong association of this kind of turnout with tobacco exposure. In ADC, our results suggest 3 distinct hypotheses:(1) activation of exogenous procarcinogens, such as small halogenated compounds by GSTTI', (2) contribution of GSTT1 to the inflammatory response of esophageal mucosa, which is known to be a strong risk factor for ADC,possibly through leukotriene synthesis; (3) higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione. | Ahmed Abbas Karine Delvinquière Mathilde Lechevrel Pierre Lebailly Pascal Gauduchon Guy Launoy Fran ois Sichel | 2004 | World Journal of Gastroenterology2004，10，23： | 7 |
| 2 | t(1 1; 14)-positive clones can persist over a long period of time in the peripheral blood of healthy individuals显示文摘 | LECLUSE Y LEBAILLY P ROULLAND S | 2009 | Leukemia2009，23，6： | 1 |
| 3 | Infant and t~ddler feed- ing patterns and probh'ms: normative data and a new direction 显示文摘 | Reau NR Senturia YI) Lebailly SA | 1996 | J Dev Behav Pediatr1996，17，3： | 1 |
| 4 | Comparison of Sensory Characteristics of Green Tea Produced in Thai Nguyen and Phu Tho Province, Vietnam显示文摘 | Dang Thi Minh Luyen Ha Duyen Tu Philippe Lebailly Nguyen Duy Thinh Tu Viet Phu | 2014 | Journal of Food Science and Engineering2014，4，2： | 1 |
| 5 | Infant and toddler feeding patterns and problems: normative data and a new direction显示文摘 | Reau NR Senturia YD Lebailly SA | 1996 | J Dev Behav Pediatr1996，17，： | 1 |
| 6 | Community ties and urbanites' fear of crime : An ecological investigation显示文摘 | RIGER S LEBAILLY R K GORDON M T | 1981 | American Journal of Community Psychology1981，9，6： | 1 |
| 7 | The MetaHUS ((R)) fixation system versus pinning and plating in 5th metacarpal neck fractures显示文摘 | Zemirline A Vaiss L Lebailly F | 2014 | Chir Main2014，33，3： | 1 |
| 8 | Community ties and urbanites’ fear of crime: An ecological investigation显示文摘 | Stephanie Riger Robert K. LeBailly Margaret T. Gordon | 1981 | American Journal of Community Psychology1981，，6： | 1 |
| 9 | Linking the circadian rhythm gene Arntl 2 to interleukin 21 expression in type 1 diabetes显示文摘 | LEBAILLY B HE C ROGNER U C | 2014 | Diabetes2014，63，6： | 1 |
| 10 | Association between Parkinson's disease and exposure to pesticides in southwestern France 显示文摘 | Baldi I Cantagrel A Lebailly P | 2003 | Neuroepiderniology2003，22，： | 1 |
| 11 | Comet assay and DNA flow cytometry analysis of staurosporine-induced apoptosis 显示文摘 | Godard T Deslandes E Lebailly P | 1999 | Cytometry1999，36，2： | 1 |
| 12 | Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities显示文摘 | LEBAILLY P WILLETT E V MOORMAN A V | 2002 | Br J Haematol2002，116，3： | 1 |
| 13 | Distal radius fixation through a mini-invasive approach of 15 mm. PART 1: a series of 144 cases显示文摘 | Frédéric Lebailly Ahmed Zemirline Sybille Facca Stéphanie Gouzou Philippe Liverneaux | 2014 | European Journal of Orthopaedic Surgery & Traumatology2014，，6： | 1 |
| 14 | Measuring the impact of a dependence among insured lifelengths显示文摘 | Denuit M Dhaene J Lebailly De Tilleghem C | 2001 | Belgian Actuarial Bulletin2001，1，： | 1 |
| 15 | Measuringthe impact of a depence among insured lifelengths显示文摘 | DENUIT M DHANCE J LEBAILLY D | 2001 | Bel- gian Actuarial Bulletin2001，26，1： | 1 |
| 16 | Bicycle-riding circumstances and injuries in school-age children:a case-control study显示文摘 | Senturia YD Morehead T LeBailly S | 1997 | Arch Pediatr Adolesc Med1997，151，： | 1 |
| 17 | Charac-terization of the t( 14;18) BCL2-lgH translocation in farmers occupationallyexposed to pesticides 显示文摘 | Roulland S Lebailly P Lecluse Y | 2004 | Cancer Res2004，64，6： | 1 |
| 18 | t ( 11 ; 14) -Positive clones can persist over a long period of time in the peripheral bloodofhealthy individuals显示文摘 | Lecluse Y Lebailly P Roulland S | 2009 | Leukemia2009，23，6： | 1 |
| 19 | Pesticide contamination of workers in vineyards in France 显示文摘 | BALDI I LEBAILLY P JEAN S | 2006 | J Expo Sci Environ Epidemiol2006，16，2： | 1 |
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