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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 3 | 高效液相色谱/氢化物发生/原子荧光快速检测尿砷形态显示文摘本文对砷形态分析方法进行了评述。提出了人尿中 As( )、As( )、一甲基砷( MMA)和二甲基砷 ( DMA)的快速、灵敏的形态分析方法。方法基于在 1 5cm长、3μm粒径的 HPL C柱上快速分离不同形态的砷后以灵敏的氢化物发生 /原子荧光检测。常见砷的四种形态的分析只须 4min即可完成 ,检出限在μg/L级。标准样品尿中砷的形态分析结果和标准值吻合很好。本法已应用于摄取砷糖前、后所采集的尿样中砷的形态分析研究。砷糖普遍存在于海藻、牡蛎、贻贝和蚌等海产品中。食用这些含有胂糖的食品后 ,尿液中的 DMA显著增加。环境和职业砷暴露的生物标志物 ( Biomarker)常基于尿液中无机砷及其代谢产物 MMA和 DMA的测定。砷糖的摄入影响这类生物标志物的可靠性 。 | Ming sheng Ma X.Chris Le 胡斌 江祖成 | 2000 | 分析科学学报2000，16，2： | 27 |
| 4 | Distinct immune response induced by peptidoglycan derived from Lactobacillus sp显示文摘AIM: To analyze the distinct immune responses induced by Lactobacillus peptidoglycan (PG).METHODS: BALB/c mice were intraperitoneally injected with PG once a day for three consecutive days. Peritoneal macrophage and splenocyte mRNA was extracted and the gene expression profile was studied using high-density oligonucleotide microarrays. Inhibitory effects of Lactobacillus PG on colon tumor tissue were studied in vitro and in vivo.RESULTS: The gene expression profiles revealed that the TLR-NF-κB and Jak-STAT signaling pathways were highly activated. An inflammatory phenotype was induced when peritoneal macrophages were initially exposed to Lactobacillus PG and switched to a more complex phenotype when BALB/c mice were treated with three doses of Lactobacillus PG. A protective physiological inflammatory response was induced after three consecutive days of PG treatment. It was tending toward Th1 dominant immune response. Lactobacillus PG also appeared to induce a significantin vivo anti-colon tumor effect.CONCLUSION: Lactobacillus PG is responsible for certain immune responses induced by Lactobacilli. Anti-tumor effects of Lactobacilli are likely to attribute to the activation of macrophages by PG expressed on the bacterial cell surface. | Jin Sun Yong-Hui Shi Guo-Wei Le Xi-Yi Ma | 2005 | World Journal of Gastroenterology2005，11，40： | 14 |
| 5 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 6 | Prevalence of asthenopia and its risk factors in Chinese college students显示文摘AIM:To determine the prevalence of asthenopia and identify any associated risk factors in the college students in Xi'an,China. METHODS:From April to September 2012,1 500 students from five universities in Xi'an were selected according to a multi-stage stratified cluster sampling method.Data on demographic features,lifestyle or dietary habits,health status,living environment conditions,sleep and mental status,and asthenopia symptoms were collected through a self-administered validated questionnaire.Univariate logistic regression and multivariate logistic regression analysis modified by the factor analysis were performed to evaluate risk factors for asthenopia.RESULTS:Fifty-seven percent of the college students complained of asthenopia.Statistically significant risk factors for asthenopia in the univariate analysis included 13 variables.Multivariate analysis revealed a significant relationship between the use of computer and asthenopia(OR 1.21,95% CI:1.09 to 1.35).Good sleep and mental status(OR 0.86,95% CI:0.76 to 0.97),good living environment conditions(OR 0.67,95% CI:0.60 to 0.76),and high intake of green leafy vegetables(OR 0.89,95% CI:0.80 to 0.98) were found to be strong predictors of decreasing the occurrence of asthenopia complaints.CONCLUSION:Asthenopia symptom appeares to be common among college students;and it is strongly associated with computer use,psychosocial state,environment conditions and dietary habits,suggesting that additional studies are warranted to verify these risk factors and establish prevention guidelines,especially for college students. | Cheng-Cheng Han Rong Liu Ru-Ru Liu Zhong-Hai Zhu Rong-Bin Yu Le Ma | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 12 |
| 7 | Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells显示文摘 | Le Ma Yun-Qian Guan Zhong-Dong Du | 2015 | Chinese Medical Journal2015，，19： | 11 |
| 8 | Culprit vessel only versus "one-week" staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction显示文摘ObjectiveTo 探索 “ 的影响; one-week”上演 multivessel 经皮的冠的干预(一种总线标准)对死亡和主要不利心脏的事件(向)上的犯人唯一的一种总线标准 .MethodsWe ;回顾地与 multivessel 疾病分析了 447 个病人经历了圣片断举起在在经历在2008年7月26日和9月25日之间的一种总线标准前的 12 h 以内的心肌的梗塞( STEMI ), 2011 。在在梗塞动脉的一种总线标准的结束以后,仍然医院里的 201 个病人同意为 “ 与超过 70% 狭窄在非梗塞动脉经历一种总线标准; one-week”上演 multivessel 一种总线标准。246 病人 only 的一个总数;为犯人容器的收到的干预。后续在 2014 年 9 月 9 日结束了。这研究从任何原因在死亡检验了差别(即,心脏并且 noncardiac ) 并且在到一条犯人唯一的一种总线标准治疗途径的二治疗 groups.ResultsCompared 之间的向, “ one-week”上演 multivessel 一种总线标准强烈与更大的好处被联系为 55 月所有原因死亡[41 (16.7%) vs.13 (6.5%) , P = 0.004 ] 并且向[82 (33.3%) 对 40 (19.9%) , P = 0.002 ] 率。另外,在心肌的梗塞的数字有重要差别[43 (17.5%) 对 20 (10.0%) , P = 0.023 ] ,冠动脉绕过 grafting [CABG;20 (8.1%) 对 6 (3.0%) , P = 0.021 ] ,并且一种总线标准[31 (12.6%) 对 12 (6.0%) , P = 0.018 ] 。与 “ 相比经历犯人唯一的一种总线标准的病人; one-week”一种总线标准有 stent 血栓事件的一样的数字[7 (2.8%) 对 3 (1.5%) , P = 0.522 ].ConclusionsCompared 到一条犯人唯一的一种总线标准治疗途径, “ one-week”上演多容器一种总线标准为 STEMI 和多容器一种总线标准是一只保险箱和有效选择。 | Li-Xiang MA Zhen-Hua LU Le WANG Xin DU Chang-Sheng MA | 2015 | Journal of Geriatric Cardiology2015，12，3： | 10 |
| 9 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 10 | Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke显示文摘Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui(GV14),Jizhong(GV6),Houhui,Guanyuan(CV4)and Zhongwan(CV12).The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter(GLAST)and glial glutamate transporter-1(GLT-1)expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured(left)side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1. | Rui-Qing Li Ming-Yue Wan Jing Shi Hui-Ling Wang Fei-Lai Liu Cheng-Mei Liu Jin Huang Ren-Chao Liu Le Ma Xiao-Dong Feng | 2018 | Neural Regeneration Research2018，13，6： | 10 |
| 11 | Ca_(1−x)Li_(x)Al_(1−x)Si_(1+x)N_(3):Eu^(2+) solid solutions as broadband,color-tunable and thermally robust red phosphors for superior color rendition white light-emitting diodes显示文摘Color rendition,luminous efficacy and reliability are three key technical parameters for white light-emitting diodes(wLEDs)that are dominantly determined by down-conversion phosphors.However,there is usually an inevitable trade-off between color rendition and luminescence efficacy because the spectrum of red phosphor(that is,spectral broadness and position)cannot satisfy them simultaneously.In this work,we report a very promising red phosphor that can minimize the aforementioned trade-off via structure and band-gap engineering,achieved by introducing isostructural LiSi_(2)N_(3) into CaAlSiN_(3):Eu^(2+).The solid solution phosphors show both substantial spectra broadening(88→117 nm)and blueshift(652→642 nm),along with a significant improvement in thermal quenching(only a 6%reduction at 150℃),which are strongly associated with electronic and crystal structure evolutions.The broadband and robust red phosphor thus enables fabrication of super-high color rendering wLEDs(Ra=95 and R9=96)concurrently with the maintenance of a high-luminous efficacy(101 lm W^(−1)),validating its superiority in highperformance solid state lightings over currently used red phosphors. | Le Wang Rong-Jun Xie Yuanqiang Li Xiaojun Wang Chong-Geng Ma Dong Luo Takashi Takeda Yi-Ting Tsai Ru-Shi Liu Naoto Hirosaki | 2016 | Light(Science & Applications)2016，5，1： | 9 |
| 12 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 13 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 14 | Investigation of mutual effects among additives in electrolyte for plasma electrolytic oxidation on magnesium alloys显示文摘Plasma electrolytic oxidation(PEO)coatings were prepared on AZ91D magnesium alloys in alkaline silicate-based electrolyte with and without additives.The mutual effects among additives including TiC particles,dispersant polyethylene glycol 6000(PEG6000)and anionic surfactant sodium dodecyl sulfate(SDS)were studied based on orthogonal experiment.The content and distribution of TiC deposited in the coatings were measured by EPMA and EDS.The thicknesses,phase compositions,microstructures and corrosion resistances of the codlings were cAarnined by using TT260 eddy current tuickncss gage,XRD,SEM and clcctrochcniical test,respectively.The results show that the experiment design of this study is the key to study the mutual effects among these additives.Each additive and their interactions all remarkably influence TiC content and corrosion resistance of the coatings.Smaller size TiC is much easier to migrate towards the anode,and the interaction between PEG6000 and SDS both effectively prevents its agglomeration and increases the number of its negative surface charges,which further increase the migration rate and the deposited uniformity of TiC and make TiC have more opportunity to deposit in the discharge channel.Thus,when smaller size TiC,PEG6000 and SDS are all added into the electrolyte,they could improve the anti-corrosion property of the coating to the largest extent attributed to higher TiC content and the densest microstructure of the coating. | Lingyun An Ying Ma Le Sun Zhanying Wang Sheng Wang | 2020 | Journal of Magnesium and Alloys2020，8，2： | 9 |
| 15 | Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury显示文摘BACKGROUND Inflammatory cytokines play a vital role in the occurrence of osteoarticular injury and inflammation. Whether inflammation-associated factors interleukin-1β(IL- 1β), IL-6, tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of keen articular cartilage injury remains poorly understood. AIM To measure the levels of inflammatory factors [IL-1β, IL-6, TNF-α and VEGF] in patients with knee articular cartilage injury. METHODS Fifty-five patients with knee articular cartilage injury were selected as patient groups, who were divided into three grades [mild (n = 20), moderate (n = 19) and severe (n = 16)] according to disease severity and X-ray examinations. Meanwhile, 30 healthy individuals who underwent physical examination were selected as the control group. The levels of IL-1β, IL-6, TNF-α and VEGF were measured by ELISA and immunohistochemical staining. RESULTS Compared with the control group, patient groups displayed significantly higher levels of IL-1β, IL-6, TNF-α and VEGF, and the extent of increase was directly proportional to the severity of injury (P < 0.05). In addition, the number of cells with positive staining of IL-1β, IL-6, TNF-α and VEGF in the synovial membrane were significantly increased, along with increased disease severity (P < 0.05). After treatment, the scores of visual analogue scale and the Western Ontario and McMaster University of Orthopaedic Index in patient groups were 2.26 ± 1.13 and 15.56 ± 7.12 points, respectively, which were significantly lower than those before treatment (6.98 ± 1.32 and 49.48 ± 8.96). Correlation analysis suggested that IL-1β and TNF-α were positively correlated with VEGF. CONCLUSION IL-1β, IL-6, TNF-α and VEGF levels are increased in patients with knee articular cartilage injury, and are associated with the disease severity, indicating they might play an important role in the occurrence and development of knee articular cartilage injury. Furthermore, therapeutically targeting them might be a novel approach for the treatment of keen articular cartilage injury. | Zhen-Wei Wang Le Chen Xiao-Rui Hao Zhen-An Qu Shi-Bo Huang Xiao-Jun Ma Jian-Chuan Wang Wei-Ming Wang | 2019 | World Journal of Clinical Cases2019，7，11： | 8 |
| 16 | An expression atlas of miRNAs in Arabidopsis thaliana显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in different organs during development of Arabidopsis thaliana have not yet been systemically investigated. In this study, we sequenced small RNA libraries generated from 27 different organ/tissue types, which cover the entire life cycle of Arabidopsis. Analysis of the sequencing data revealed that most miRNAs are ubiquitously expressed, whereas a small set of miRNAs display highly specific expression patterns. In addition, different miRNA members within the same family have distinct spatial and temporal expression patterns. Moreover, we found that some miRNAs are produced from different arms of their hairpin precursors at different developmental stages. This work provides new insights into the regulation of miRNA biogenesis and a rich resource for future investigation of miRNA functions in Arabidopsis. | Le Xu Yugang Hu Ying Cao Jingrui Li Ligeng Ma Yan Li Yijun Qi | 2018 | Science China(Life Sciences)2018，61，2： | 8 |
| 17 | Mechanical Properties and Microstructure of In Situ TiB_2-7055 Composites显示文摘In order to fabricate a kind of high strength particulate reinforced aluminum-matrix composites, the high strength aluminum alloy 7055 was selected as a matrix. Composites reinforced with varying amounts of TiB2 particles were synthesized using the in situ method, and their mechanical properties and microstructure were analyzed. It is found that the in situ TiB2 particles sized from 50 to 400 nm uniformly disperse in the matrix. With the weight fraction of TiB2 particles increasing, the elastic modulus as well as the yield strength and the ultimate tensile strength increase, while the ductility decrease. The improvement of strength could be attributed to good bonding between TiB2 and the matrix, and also the TiB2 particles act as a barrier to dislocation. | CHEN dong LE Yong-kang BAI Liang MA Nai-heng LI Xian-feng WANG Hao-wei | 2006 | Chinese Journal of Aeronautics2006，19，B12： | 8 |
| 18 | Efficient spectral regulation in Ce:Lu_(3)(Al,Cr)_(5)O_(12) and Ce:Lu_(3)(Al,Cr)_(5)O_(12)/Ce:Y_(3)Al_(5)O_(12) transparent ceramics with high color rendering index for high-power white LEDs/LDs显示文摘Realizing a high color rendering index(CRI)in Ce:LuAG transparent ceramics(TCs)with desired thermal stability is essential to their applications in white LEDs/LDs as color converters.In this study,based on the scheme of configuring the red component by Cr^(3+) doping,an efficient spectral regulation was realized in Ce,Cr:LuAG TCs.A unilateral shift phenomenon could be observed in both photoluminescence(PL)and photoluminescence excitation(PLE)spectra of TCs.By constructing TC-based white LED/LD devices in a remote excitation mode,luminescence properties of Ce,Cr:LuAG TCs were systematically investigated.The CRI values of Ce:LuAG TC based white LEDs could be increased by a magnitude of 46.2%.Particularly,by combining the as fabricated Ce,Cr:LuAG TCs with a 0.5 at% Ce:YAG TC,surprising CRI values of 88 and 85.5 were obtained in TC based white LEDs and LDs,respectively.Therefore,Ce,Cr:LuAG TC is a highly promising color convertor for high-power white LEDs/LDs applied in general lighting and displaying. | Tianyuan ZHOU Chen HOU Le ZHANG Yuelong MA Jian KANG Tao LI Rui WANG Jin HUANG Junwei LI Haidong REN Zhenxiao FU Farida ASELIM Ming LI Hao CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 7 |
| 19 | NUMERICAL SIMULATION OF HIGHLY UNDEREXPANDED AXISYMMETRIC JET WITH RUNGE-KUTTA DISCONTINUOUS GALERKIN FINITE ELEMENT METHOD显示文摘Highly underexpanded axisymmetric jet was simulated using the Runge-Kutta Discontinuous Galerkin (RKDG) finite element method, which, based on two-dimensional conservation laws, was used to solve the axisymmetric Euler equations. The computed results show that the complicated flow field structures of interest, including shock waves, slipstreams and the triple point observed in experiments could be well captured using the RKDG finite element method. Moreover, comparisons of the Mach disk location exhibit excellent agreements between the computed results and experimental measurements, indicating that this method has high capability of capturing shocks without numerical oscillation and artificial viscosity occurring near the discontinuous point. | CHEN Er-yun MA Da-wei LE Gui-gao WANG kai ZHAO Gai-ping | 2008 | Journal of Hydrodynamics2008，20，5： | 7 |
| 20 | MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis显示文摘Background Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease in childhood driven by aberrant pathways of T-cell activation.T helper 17(Th17)/regulatory T cell(Treg)imbalance plays critical roles in the pathogenesis of arthritis.MicroRNA-125b(miR-125b)was upregulated after the activation of the initial CD4^+T cells,and could regulate the differentiation of CD4^+T cells.However,the effects of miR-125b on Th17/Treg imbalance and differentiation of Th 17/Treg cells remain unknown.Methods In this study,we evaluated the expression of miR-125b in the peripheral blood mononuclear cells(PBMCs)of children with JIA,and the relationship of miR-125b with Th17/Treg imbalance.Then,we used lentivirus vector-mediated overexpression technology to investigate the regulatory function of miR-125b in CD4^+T cells or dendritic cell/CD4^+T co-culture system.Results Decreased miR-125b expression in PBMCs and CD4^+T cells of JIA patients was negatively correlated with the ratio of Th17/Treg cells.It also correlated negatively with retinoic acid receptor-related orphan receptorγt but positively with Forkhead box protein 3 at transcriptional levels.Furthermore,we found that miR-125b overexpression inhibited Th17 cell differentiation,whereas facilitated the differentiation of Treg cells.MiR-125b upregulation led to the decrease of Th 17-secreting cytokines but the increase of the Treg-secreting cytokines.Conclusions Our results demonstrate that miR-125b participated in regulating Thl7/Treg cell differentiation and imbalance in JIA patients.These findings provide novel insight into the critical role of miR-125b in the Th17/Treg imbalance of JIA,and raise the distinct possibility that miR-125b may prove to be a potential therapeutic target for JIA. | Zhi-Dan Fan Qian Cao Na Huang Le Ma Hui-Hui Ma Ya-Yuan Zhang Hai-Guo Yu Guo-Ping Zhou | 2020 | World Journal of Pediatrics2020，16，1： | 7 |
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