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| 1 | Surface bioactivation of PEEK by neutral atom beam technology显示文摘Polyetheretherketone(PEEK)is an alternative to metallic implants and a material of choice in many applications,including orthopedic,spinal,trauma,and dental.While titanium(Ti)and Ti-alloys are widely used in many intraosseous implants due to its biocompatibility and ability to osseointegrate,negatives include stiffness which contributes to shear stress,radio-opacity,and Ti-sensitivity.Many surgeons prefer to use PEEK due to its biocompatibility,similar elasticity to bone,and radiolucency,however,due to its inert properties,it fails to fully integrate with bone.Accelerated Neutral Atom Beam(ANAB)technology has been successfully employed to demonstrate enhanced bioactivity of PEEK both in vitro and in vivo.In this study,we further characterize surfaces of PEEK modified by ANAB as well as elucidate attachment and genetic effects of dental pulp stem cells(DPSC)exposed to these surfaces.ANAB modification resulted in decreased contact angle at 72.9±4.5°as compared to 92.4±8.5°for control(p<0.01)and a decreased average surface roughness,however with a nano-textured surface profile.ANAB treatment also increased the ability of DPSC attachment and proliferation with considerable genetic differences showing earlier progression towards osteogenic differentiation.This surface modification is achieved without adding a coating or changing the chemical composition of the PEEK material.Taken together,we show that ANAB processing of PEEK surface enhances the bioactivity of implantable medical devices without an additive or a coating. | Joseph Khoury Irina Selezneva Sergei Pestov Vadim Tarassov Artem Ermakov Andrey Mikheev Mikhail Lazov Sean R.Kirkpatrick Dmitry Shashkov Alexandre Smolkov | 2019 | Bioactive Materials2019，4，1： | 2 |
| 2 | A new approach to three-dimensional sonographic: representation of the infant hip显示文摘 | J. Franke D. Lazovic H. M. Overhoff U. v. Jan O. Rühmann | 1997 | Der Orthop?de1997，，3： | 1 |
| 3 | Electrodiagnostic evalua- tion of patients with carpal tunnel syndrome regarding the pres- ence of subjective and physical findings显示文摘 | Radovic D Lazovic M Nikolic D | 2014 | Arch Ital Biol2014，152，1： | 1 |
| 4 | Investigation of causes of fan shaft failure显示文摘 | M Ristivojevic R Mitrovic T Lazovic | 2010 | Engineering Failure Analysis2010，17，5： | 1 |
| 5 | [Standardized sonographic investigation of the lumbar spine in 247 newborns]显示文摘 | Vocke AK Rühmann O Lazovic D | | 0，，01： | 1 |
| 6 | Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease 显示文摘 | Zinnanti WJ Lazovic J Griffin K | 2009 | Brain2009，132，4： | 1 |
| 7 | Evaluation of low level laser and interferential current in the therapy of complex regional pain syndrome by infrared thermographic camera显示文摘 | Kocic M Lazovic M Dimitrijevic I | | 0，，09： | 1 |
| 8 | Interrupting the mechanisms ofbrai injury in a model of maple syrup urine disease encephalopath 显示文摘 | Zirmanti WJ Lazovic J | 2012 | J Inherit Metab Dis2012，35，1： | 1 |
| 9 | Fetal free thyroxine concentrations in pregnant women with autoimmune thyroid disease显示文摘 | Spremovic-Radjenovic S Gudovic A Lazovic G | 2012 | J Clin Endocrinol Metab2012，97，11： | 1 |
| 10 | High tibia1 osteotomy versus unicompartmental joint replacement in unicompartmental knee joint osteoarthritis:7-10-year follow-up prospective randomized study 显示文摘 | Stukenborg-Colsman C Wirth CJ Lazovic D | 2001 | Knee2001，8，3： | 1 |
| 11 | Correlation of CRP and serum level of fibrinogen with sev- erity of disease in chronic obstructive pulmonary disease patients 显示文摘 | Lazovic B | 2012 | Med Arh2012，66，3： | 1 |
| 12 | Mathematical model of load distribution in rolling bearing显示文摘 | Tatjana Lazovic Mileta Ristivojevic Radivoje Mitrovic | 2008 | Faculty of Mechanical Engineering2008，，36： | 1 |
| 13 | Inevitable cesarean myomectomy following delivery through poserior hysterotomy in a case of ureine torsion 显示文摘 | Sparic R Lazovic B | 2013 | Med Arh2013，，： | 1 |
| 14 | Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemie injury显示文摘 | Basu A Lazovic J Krady JK | 2005 | J Cereb Blood Flow Metab2005，25，： | 1 |
| 15 | High tibial osteot-omy versus unicompartmental joint replacement in unicompartmentalknee joint osteoarthritis:7-10-year follow-up prospective randomisedstudy显示文摘 | Stukenborg-Colsman C Wirth C J Lazovic D | 2001 | Knee2001，3，： | 1 |
| 16 | High tibial osteotomy versus unicompartmcntal joint replacement in unicompartmental knee joint osteoarthritis :7 - 10 - year follow - up prospective randomised study显示文摘 | Stukenborg - Colsman C Wirth C J Lazovic D | 2001 | Knee2001，3，： | 1 |
| 17 | Association between atherosclerosis and osteoporosis,the role of vitamin D显示文摘 | Stojanovic OI Lazovic M Vuceljic M | | 0，，： | 1 |
| 18 | High tibial osteotomy versus unicompartmental joint replacement in unicompartmental knee joint osteoarthritis:7 - 10 - year follow - up prospective randomised study 显示文摘 | Stukenborg - Colsman C Wirth C J Lazovic D | 2001 | Knee2001，8，3： | 1 |
| 19 | A dietinduced mouse model for glutaric aciduria type Ⅰ显示文摘 | Zinnanti W J Lazovic J Wolpert E B | | Brain0，，： | 1 |
| 20 | Tibolone and osteoporosis显示文摘 | LAZOVIC G RADIVOJEVI U MILOSEVIC V | 2007 | Arch Gynecol Obstet2007，276，： | 1 |
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