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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle显示文摘Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated Holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina Hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, R.champanellensis, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as Megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate < 0.01). Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation analysis of the DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate binding modules were enriched in steers fed YEA. These results confirm the effectiveness of a live S. cerevisiae product for improving rumen function in beef steers by increasing the abundance of cellulolytic bacteria, lactic acid-utilizing bacteria, and carbohydrate-active enzymes in the rumen. | Ibukun M.Ogunade Jerusha Lay Kenneth Andries Christina J.Mc Manus Frederick Bebe | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 11 |
| 3 | 中国居民膳食指南(2016):评价和比较(英文)显示文摘高质量的膳食在促进人类健康成长和防治包括癌症、心血管疾病、糖尿病和肥胖在内的多种慢性疾病中起着重要的作用。坚持高质量的膳食能有效地降低死亡率。为了帮助形成健康的生活方式,增强体质,中国政府发布了新的中国居民膳食指南(2016)和膳食宝塔,用来指导居民膳食的摄入。同样,日本政府早期发布了日本膳食指南陀螺模型,美国政府最近也出版了修订后的第八版美国居民膳食指南(2015–2020)。与指南相关的同期证据表明,遵循指南进行膳食指导,许多慢性疾病的发病率和死亡率都会降低。所有的科学发现支持鼓励居民在保证营养和食物摄入的基础上消耗各种各样的食物以防止营养缺乏疾病以及能量和营养过剩,并且建议进行日常活动来保持身体健康。 | Shan-shan WANG Sovichea LAY Hai-ning YU Sheng-rong SHEN | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，9： | 11 |
| 4 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 5 | Selective methanation of carbon monoxide in hydrogen rich stream over Ni/CeO_2 nanocatalysts显示文摘In the present work, selective methanation of carbon monoxide in hydrogen rich stream was investigated over Ni/CeO2 nanocatalysts. The obtained results revealed that increasing in nickel loading decreased the BET surface area, pore volume and nickel dispersion. The 25% Ni/CeO2 with a NiO crystal size of 12 nm exhibited the highest activity in CO methanation reaction and reached to maximum CO conversion and CH4 selectivity at temperatures above 230 ℃. The catalytic results revealed that CO selective methanation well progressed at lower temperatures while CO2 methanation was completely suppressed until CO conversion reached to maximum value. | Behzad Nematollahi Mehran Rezaei Ebrahim Nemati Lay | 2015 | Journal of Rare Earths2015，33，6： | 6 |
| 6 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 7 | Thermodynamic analysis of combined reforming process using Gibbs energy minimization method: In view of solid carbon formation显示文摘Thermodynamic analysis was applied to study combined partial oxidation and carbon dioxide reforming of methane in view of carbon formation. The equilibrium calculations employing the Gibbs energy minimization were performed upon wide ranges of pressure (1-25 atm), temperature (600-1300 K), carbon dioxide to methane ratio (0-2) and oxygen to methane ratio (0-1). The thermodynamic results were compared with the results obtained over a Ru supported catalyst. The results revealed that by increasing the reaction pressure methane conversion decreased. Also it was found that the atmospheric pressure is the preferable pressure for both dry reforming and partial oxidation of methane and increasing the temperature caused increases in both activity of carbon and conversion of methane. The results clearly showed that the addition of O 2 to the feed mixture could lead to a reduction of carbon deposition. | Behzad Nematollahi Mehran Rezaei Ebrahim Nemati Lay Majid Khajenoori | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 4 |
| 8 | 年龄相关性黄斑变性的脉络膜厚度评价(英文)显示文摘目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60~82)岁,对照组受试者平均年龄为71.2±8.8(58~81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P<0.05)。非新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异无统计学意义(P>0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。 | Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu Sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel | 2014 | 国际眼科杂志2014，14，9： | 4 |
| 9 | The quasiparticle band dispersion in epitaxial multilayer silicene显示文摘 | Paola De Padova Jose Avila Andrea Resta Ivy Razado-Colambo Claudio Quaresima Carlo Ottaviani Bruno Olivieri Thomas Bruhn Patrick Vogt Maria Carmen Asensio Guy Le Lay | 2013 | Journal of Physics: Condensed Matter2013，，： | 4 |
| 10 | Theoretical and Experimental Study on the Adsorption and Desorption of Methane by Granular Activated Carbon at 25℃显示文摘理论、试验性的研究被进行精确地在不同物理条件下面由各种各样的小粒的激活的碳(GAC ) 决定吸附的数量和甲烷的解吸附作用。执行实验,容量的方法被使用直到 500 希腊语的第二十三个字母 25 ° C 的 at 常数温度。在这些实验,吸附以及在甲烷的吸附的四不同 GAC 的解吸附作用能力,天然气的主要成分,在各种各样的平衡压力和一个常数,温度被学习。另外,各种各样的吸附等温线模型被用来为从实验收集的试验性的数据建模。从吸附等温线模型获得的结果的精确性被比较,为 regressed 参数的值被报导。结果证明象赌注表面区域,微毛孔体积,收拾行李的密度,和毛孔那样的激活的碳的物理特征缩放分发玩在要吸附并且使放出的甲烷的数量的一个重要角色。 | E.Salehi V.Taghikhani C.Ghotbi E.Nemati Lay A.Shojaei | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 4 |
| 11 | An accurate empirical correlation for predicting natural gas viscosity显示文摘Natural gas viscosity is an important parameter in many gas and petroleum engineering calculations.This study presents a new empirical model for quickly calculating the natural gas viscosity.The model was derived from 4089 experimental viscosity data with varieties ranging from 0.01 to 21,and 1 to 3 of pseudo reduced pressure and temperature,respectively.The accuracy of this new empirical correlation has been compared with commonly used empirical models,including Lee et al.,Heidaryan et al.,Carr et al.,and Adel Elsharkawy correlations.The comparison indicates that this new empirical model can predict viscosity of natural gas with average absolute relative deviation percentage AARD (%) of 2.173. | Ehsan Sanjari Ebrahim Nemati Lay Mohammad Peymani | 2011 | Journal of Natural Gas Chemistry2011，20，6： | 4 |
| 12 | 亲和性促生菌DW12-L的定殖及其对大豆生长的影响显示文摘为了研究大豆亲和性根际促生菌(PGPR)菌株在大豆根际的定殖及其对大豆生长发育的影响,采用电转化法将luxAB基因转入对大豆凝集素(SBA)具有亲和性的PGPR菌株DW12中。将标记菌株DW12?L接种于大豆品种中黄606根际,以SBA非亲和的PGPR菌株P34?L作对照,考察DW12?L在大豆根际定殖的时空特征,检测菌株的定殖对大豆生长以及根系发育的影响。结果表明,DW12?L可长期定居于大豆根际,并随根系的生长在新的根段根际吸附定殖,而P34?L在大豆根际不能稳定存活;DW12?L显著促进大豆地上部和地下部生物量的积累以及根系的发育,P34?L在大豆生长30 d时由于不能定殖于根际而无显著促生效果。与大豆凝集素具有亲和性的PGPR菌株DW12?L可定殖于大豆根际并促进大豆生长,定殖能力的强弱是决定菌株能否发挥促生功能的关键。 | 曹媛媛 陈春 郭婷婷 钱叶 张程飞 何相怡 李婷 Lay Khien Duc 唐欣昀 邵文韬 王晓波 邱丽娟 | 2019 | 江苏农业学报2019，35，4： | 3 |
| 13 | Brains, bacteria and behaviors: the role of interferon-gamma in the pathogenesis of pneumococcal meningitis显示文摘of bacterial meningitis that occurs following brain infection by the Gram-positive cocci Streptococcus pneumoniae.Not only does it cause acute mortality,but pneumococcal meningitis also accounts for the highest proportion of survivors living with neurological sequelae,including behavioral disorders,cognitive deficits,hearing loss,motor impairment and epilepsy.More than 90 distinct pneumococcal serotypes have been identified worldwide based on their capsular compositions and serological responses.Serotype replacement continually poses great challenge to costly vaccination programs in developed countries(Koelman et al.,2020),this has therefore emphasized the need to develop new treatment strategies in addition to improving vaccine coverage. | Lay Khoon Too Andrew Mitchell | 2021 | Neural Regeneration Research2021，16，1： | 3 |
| 14 | 关于一类不可微规划问题的对偶性显示文摘作者构造了一类不可微规划问题的一阶和二阶对偶模型,其目标函数含有紧凸集的支撑函数项。利用FritzJohn最优性必要条件,在适当条件下建立了这两类一阶和二阶对偶模型的弱和逆对偶性定理。 | 杨新民 KOK LAY TEO | 2005 | 重庆师范大学学报(自然科学版)2005，22，3： | 3 |
| 15 | Growth of Si nanostructures on Ag(001)显示文摘 | C. Léandri H. Oughaddou B. Aufray J.M. Gay G. Le Lay A. Ranguis Y. Garreau | 2006 | Surface Science2006，，： | 3 |
| 16 | Physics of Silicene Stripes显示文摘 | A. Kara C. Léandri M. E. Dávila P. Padova B. Ealet H. Oughaddou B. Aufray G. Lay | 2009 | Journal of Superconductivity and Novel Magnetism2009，，： | 3 |
| 17 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 18 | Reflectance properties and physiological responses of Salicornia virginica to heavy metal and petroleum contamination显示文摘 | Pablo H. Rosso James C. Pushnik Mui Lay Susan L. Ustin | 2005 | Environmental Pollution2005，，2： | 3 |
| 19 | Experimental and Theoretical Study of the Effect of Moisture on Methane Adsorption and Desorption by Activated Carbon at 273.5 K显示文摘由在恒温并且在各种各样的压力的活性炭(交流) 的甲烷的吸附和解吸附作用被调查。潮湿的效果也被学习。一个容量的方法被使用,直到 40 酒吧,在 273.5 K 的温度。一件干燥交流样品的结果与从一件潮湿的样品和二不同交流获得与的那些相比不同物理并且表面性质被使用。是期望,结果证明潮湿的存在,在 AC 毛孔套住,能在在解吸附作用期间交付的甲烷的数量在吸附的甲烷和减少的数量导致减少。为试验性的结果建模,吸附等温线的一个大变化被使用。为吸附等温线的 regressed 参数用在现在的学习产生的试验数据被获得。从不同吸附等温线获得的结果的精确性有利地被比较。给词调音:活性炭;吸附;吸附性质; | S.Farzad V.Taghikhani C.Ghotbi B.Aminshahidi E.Nemati Lay | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 3 |
| 20 | Various atomic structures of monolayer silicene fabricated on Ag(111)显示文摘 | Zhi-Long Liu Mei-Xiao Wang Jin-Peng Xu Jian-Feng Ge Guy Le Lay Patrick Vogt Dong Qian Chun-Lei Gao Canhua Liu Jin-Feng Jia | 2014 | New Journal of Physics2014，，： | 3 |
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