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| 1 | Two-dimensional speckle tracking echocardiography for the assessment of atrial function显示文摘Echocardiography is the most common diagnostic method for assessing atrial function but the technique has some limitations. Traditionally, assessment of left atrial function has been performed by measuring volumes with 2D echocardiography. Additionally, it can be assessed with transmitral Doppler and pulmonary vein Doppler. Recently, an alternative method has been incorporated, namely, measurement of myocardial deformation with color tissue Doppler-derived strain. However, this method has several limitations, such as suboptimal reproducibility, angle-dependence, signal artifacts and the fact that it only measures regional strain and does not obtain information about the curved portion of the atrial roof. To overcome these limitations in the quantification of atrial function, the use of speckle tracking echocardiography (STE) strain has been proposed. This technique is not derived from Doppler but rather from 2D echocardiography; it is angle-independent and allows one to measure global as well as regional atrial strain. In this editorial, we describe the physical and pathophysiological concepts of STE and underline the clinical usefulness of this new technique. | Tomás Francisco Cianciulli María Cristina Saccheri Jorge Alberto Lax Alejandra Marina Bermann Daniel Ernesto Ferreiro | 2010 | World Journal of Cardiology2010，2，7： | 39 |
| 2 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 3 | Hydrolysis of filter-paper cellulose to glucose by two recombinant endogenous glycosyl hydrolases of Coptotermes formosanus显示文摘 | Dunhua Zhang Alan R. Lax John M. Bland Jiujiang Yu Natalie Fedorova William C. Nierman | 2010 | Insect Science2010，17，3： | 3 |
| 4 | The value of specific MRI features in the evaluation of suspected placental invasion显示文摘 | Allison Lax Martin R. Prince Kevin W. Mennitt J. Reid Schwebach Nancy E. Budorick | 2007 | Magnetic Resonance Imaging2007，，1： | 2 |
| 5 | Complete regression of myocardial involvement associated with lymphoma following chemotherapy显示文摘Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence.We describe the case of a 26 year old man who had initially been diagnosed with myocardial infiltration on an echocardiogram,presenting with a testicular mass and unilateral peripheral facial paralysis.On admission,electrocardiograms(ECG)revealed negative T-waves in all leads and ST-segment elevation in the inferior leads.On twodimensional echocardiography,there was infiltration of the pericardium with mild effusion,infiltrative thickening of the aortic walls,both atria and the interatrial septum and a mildly depressed systolic function of both ventricles.An axillary biopsy was performed and reported as a T-cell lymphoblastic lymphoma(T-LBL).Following the diagnosis and staging,chemotherapy was started.Twenty-two days after finishing the first cycle of chemotherapy,the ECG showed regression of T-wave changes in all leads and normalization of the ST-segment elevation in the inferior leads.A followup two-dimensional echo confirmed regression of the myocardial infiltration.This case report illustrates a lymphoma presenting with testicular mass,unilateral peripheral facial paralysis and myocardial involvement,and demonstrates that regression of infiltration can be achieved by intensive chemotherapy treatment.To our knowledge,there are no reported cases of T-LBL presenting as a testicular mass and unilateral peripheral facial paralysis,with complete regression of myocardial involvement. | Juan Pablo Vinicki Tomás F Cianciulli Gustavo A Farace María C Saccheri Jorge A Lax Lucía R Kazelián Adolfo Wachs | 2013 | World Journal of Cardiology2013，5，9： | 2 |
| 6 | Structure of a heparin-linked biologically active dimer of fibroblast growth factor显示文摘 | Lax I Chen DI | 1998 | Nature1998，393，6678： | 1 |
| 7 | Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator显示文摘 | Lax I Naslund I | 1995 | Acta Oncol1995，34，： | 1 |
| 8 | Weak solutions of nonlinear hyperbolic equations and their numerical computation显示文摘 | Lax P D | 1954 | Comm Pure Appl Math1954，7，： | 1 |
| 9 | Non-photochemical quenching: A response to excess light energy显示文摘 | Muller P lax P Niyogik K | 2001 | Plant Physiol2001，125，： | 1 |
| 10 | Development of singularities of solution of nonlinear hyperbolic partial differential equations 显示文摘 | Lax P D | 1964 | Math Phys1964，5，： | 1 |
| 11 | Inhibition of some mycotoxigenic fungi by iturin A, a peptidolipid produced by Bacillus subtilis显示文摘 | M. A. Klich A. R. Lax J. M. Bland | 1991 | Mycopathologia1991，，2： | 1 |
| 12 | Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+)myeloid dendritic cells from healthy donors and advanced cancer patients;inhibition of p38 enhances IL-12 whilst suppressing IL-10显示文摘 | Franks HA Wang Q Lax SJ | 2014 | Int J Cancer2014，134，3： | 1 |
| 13 | Role of gross tumor volume on outcome and of dose parameters on toxicity of patients undergoing chemoradiotherapy for locally advanced non-small cell lung cancer 显示文摘 | Petris DL Lax I Sirzen F | 2005 | Med Oncol2005，22，4： | 1 |
| 14 | Iturin A: a potential new fungicide for stored gains显示文摘 | Klich M A Arthur K S Lax A R | 1994 | Mycopathologia1994，127，2： | 1 |
| 15 | Effect of imidacloprid tree treatments on theoccurrence of formosan subterranean termites, Coptotermes formosanusShiraki (Isoptera: Rhinotermitidae) ,in independent monitors显示文摘 | OSBRINK W L LAX A R | 2003 | J EconEntomol2003，96，1： | 1 |
| 16 | The value of specific MRI features in the evaluation of suspected pla- cental invasion显示文摘 | Lax A Prince MR Mennitt KW | 2007 | Magn Reson Imaging2007，25，1： | 1 |
| 17 | Cellular signaling by fibroblast growth factor receptors显示文摘 | V.P. Eswarakumar I. Lax J. Schlessinger | 2004 | Cytokine and Growth Factor Reviews2004，，2： | 1 |
| 18 | Clinical results of anti- inflammatory therapy in Graves' ophthalmopathy and association with thyroidal autoantibodies 显示文摘 | Eckstein AK Plicht M Lax H | 2004 | Clin Endoerinol (Oxf)2004，61，5： | 1 |
| 19 | Stereotactic high dose fraction radiation therapy of extracranial tumors using an acce lerator:elinical experience of the first thirty one patients显示文摘 | BLOMGREN H LAX I NASLUND I | 1995 | Acta Oncol1995，34，6： | 1 |
| 20 | Molecular genetic pathways in various types of endometrial carcinoma:from a phenotypical to a molecular-based classification显示文摘 | Lax SF | 2004 | Virchows Arch2004，444，： | 1 |
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