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| 1 | Effect of TGF-131 antisense oligodeoxynucleotide on renal function in chronic renal failure rats显示文摘目的:学习是调查转变生长因素( TGF )贝它 1 反的有效性的礼品的目的在改善察觉到 oligodeoxynucleotides ( ODN )在有 导致puromycin 的长期的肾衰竭( CRF )的老鼠的败坏的肾功能 .Methods :盐,嘌呤霉素,puromycin+TGF贝它 1 反感觉 ODN 或 puromycin+scrambled ODN 予被以单方地 nephrecto-mized 老鼠。肾的血液动力学、分泌的大小在经历了外科的 procedure.Results 的使麻木的老鼠被拿:在 CRF 老鼠,在肾的血流( RBF )有显著减小,这被观察, glomerular 率( GFR ),严重蛋白尿,并且几乎6褶层在控制老鼠作为与那相比增加了钠( FE Na^+)的部分排泄(所有 P < 0.05 )。在 CRF 老鼠,有 1 反察觉到的 TGF 贝它的处理,然而并非爬的 ODN,显著地稀释了 RBF, GFR,和蛋白尿的减小并且显著地阻止了 FE Na^+ 的增加,这进一步被观察(所有 P < 0.05 ) 。另外,在 CRF 的肾的肥大组织(P < 0.05 对非肾的失败控制) 是有 TGF-1 反感觉 ODN 的显著地稀释的术后疗法(P < 0.05 ) 。焦点的部分肾小球硬化症在未经治疗、爬的对待 ODN 的 CRF 组仅仅是明显的。这研究的有趣的观察在 CRF 老鼠是那,尽管有显著 attenuating 和TGF贝它的预防效果败坏的肾的功能上的 1 反感觉 ODN ,反感觉处理没在TGF贝它的肾的表示引起任何显著变化 1 在蛋白质 level.Conclusion :一起,获得的数据建议 1 反感觉 ODN 拥有的那TGF贝它在 导致puromycin 的长期的肾衰竭的有益的效果并且在形态学的恶化和处于这个病理学的状态的损害肾的功能部分地依赖于TGF贝它的行动 1 在肾以内。 | Law Chung HIONG Kiew Lik VOON Nor Azizan ABDULLAH Munavvar A SATTAR Nazarina Abdul RAHMAN Abdul Hye KHAN4, Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，4： | 7 |
| 2 | Protection of Linguistic Rights in China显示文摘The International Community has become increasingly keen on linguistic rights, regarding such rights as important human rights. The International Academy of Linguistic Law (IALL) has organized eight international conferences on the subject, with the question of linguistic rights featuring prominently in all of them. Back in 1996, the Hong Kong Polytechnic University played host to an international | SU JINZHI director of the Social and Media Linguistics Division of the Institute of Linguistic Application under the Chinese Ministry of Education, and concurrently a Chinese member of the Preparatory Committee for the Ninth International Linguistic Law Conference. | 2003 | The Journal of Human Rights2003，2，6： | 3 |
| 3 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 4 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 5 | The high-molecular-weight subunits of glutenin:structure,genetics and relationship to bread-making quality显示文摘 | Payne P I Harris P A Law C N Holt L M Blackman J A | 1980 | Ann Technol Agric1980，29，2： | 2 |
| 6 | The central role of fat and effect of peroxisome proliferator- activated receptor-gamma on progression of insulin resistance and cardiovascular disease显示文摘 | Hsueh W A Law R | 2003 | Am J Cardiol2003，92，4： | 2 |
| 7 | Esophageal lichen planus:A case report and review of the literature显示文摘Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than rare.To date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate follow-up.In this case report,a 69-year-old female presented with dysphagia and odynophagia.She reported a history of oral LP but had no active oral or skin lesions.Endoscopic examination revealed severe strictures and web-like areas in the esophagus.Histologic examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic cells.Direct immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous disorders.By using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up. | Jennifer A Nielsen Robert M Law Keith H Fiman Cory A Roberts | 2013 | World Journal of Gastroenterology2013，19，14： | 1 |
| 8 | Photosynthetic efficiency optimization studies with the macroalga Gracilaria tikvihae: implications for CO2 emission control from power plants显示文摘 | Berning J L | 1991 | Bioresource Technology1991，37，： | 1 |
| 9 | A parvo-like virus in the giant freshwater prawn, Macrobrachium rosenbergii 显示文摘 | Anderson I G Law A T Shariff M | 1990 | Invertebr Pathol1990，55，3： | 1 |
| 10 | Peptide composition of enzyme-treated Cheddar cheese slurries,determined by reverse phase high performance liquid chromatography显示文摘 | A J Cliffe B A Law | 1990 | Food Chemistry1990，36，1： | 1 |
| 11 | Quantifying effect of statins on low density lipoprotein cholesterol,ischaemic heart disease,and stroke:systematic review and meta-analysis显示文摘 | LAW M R WALD N J RUDNICKA A R | 2003 | BMJ2003，326，7404： | 1 |
| 12 | Comparison of the effects of high-pressure treatments and heat pasteurisation on the whey proteins in goat's milk显示文摘 | Felipe X Capellas M Law A R | 1997 | Journal of Agricultural and Food Chemistry1997，45，3： | 1 |
| 13 | Effect of protein concentration on rates of thermal denaturation of whey protein in milk 显示文摘 | Law A J R Leaver J | 1997 | Agrieahural Food Chemistry1997，45，： | 1 |
| 14 | Pad conditioning and surface characterization in oxide chemical mechanical polishing显示文摘 | LAWING A S | 2002 | Mater Res Soc2002，15，3： | 1 |
| 15 | A simpfified model for the com- bustion of uncoated boron particles 显示文摘 | Makino A Law C K | 1988 | Combustion Sci- ence and Technology1988，61，： | 1 |
| 16 | Global burden of blood-pressure-related disease: 2001 显示文摘 | Lawes CM Vander Hoom S Rodgers A | 2008 | Lancet2008，371，9623： | 1 |
| 17 | Reactiva-tion of peroxi-some proliferator- activated receptora is associat-ed with contractile dysfunction in hypertrophied rat heart 显示文摘 | YOUNG M E LAWS F A GOODWIN G W | 2001 | JBiol Chem2001，276，44： | 1 |
| 18 | Large-eddy simulation of starting buoyant jets显示文摘 | Wang R Q Law A W K Adams E E | 2011 | Environmental Fluid Mechanics2011，11，6： | 1 |
| 19 | Majorana Fermion induced resonant andreev reflection显示文摘 | Law K T Lee P A Ng T K | | 0，，23： | 1 |
| 20 | Recurrent nasopharyngeal carcinoma:the puzzles of long latency显示文摘 | LEE A W FOO W LAW S C | | 0，，01： | 1 |
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