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| 1 | 子二代中华鲟分枝杆菌感染及血液生理生化指标的变化显示文摘鱼类分枝杆菌病是由分枝杆菌属的非结核分枝杆菌造成的长期性感染疾病。本研究发现,养殖中华鲟(Acipenser sinensis)子二代可感染该病,典型病理特征是腹水、腹膜肉芽肿、肾脏水肿、肝脏呈灰白色等。采集腹水,通过细菌分离培养获得一株缓慢生长型的抗酸杆菌,进一步通过16S r DNA和IS2404重复序列进行分子生物学鉴定,发现该菌与Mycobacterium liflandii相似性最高。将10尾健康子二代中华鲟3次体检的血液参数与4尾分枝杆菌感染子二代中华鲟12次检查的血液参数进行比较,发现在26项生理生化指标中,有9项指标差异显著(P<0.05),即中性粒细胞、淋巴细胞、钠、氯、钙、总蛋白、球蛋白、外周血白细胞总数(TWBC)和谷丙转氨酶(ALT),其中TWBC、中性粒细胞和ALT这3项指标显著升高,其他指标显著下降,说明分枝杆菌感染对鱼体肝脏和肾脏的损伤较大。采用盐酸卡纳霉素、红霉素和利福平三种抗生素联合用药进行治疗,给药时间75 d,治疗后腹水明显减少,RBC、血红蛋白、PCV、MCV和球蛋白这5项血液理化指标均有显著性升高(P<0.05),说明药物治疗初期具有一定的效果,但随着病程的加剧,该尾鱼最终未能治愈。以上结果表明,分枝杆菌在中华鲟广泛流行,对中华鲟的危害较大,目前尚未见有效的疫苗和药物,因此对该病的预防、早期诊断和治疗极其重要。 | 张书环 聂品 舒少武 杜浩 Foo Khong Lee 杨月梅 邵纯 邸军 黄君 曾令兵 危起伟 | 2017 | 中国水产科学2017，24，1： | 16 |
| 2 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 3 | Investigation into the Vibration of Metro Bogies Induced by Rail Corrugation显示文摘The current research of rail corrugation mainly focuses on the mechanisms of its formation and development. Compared with the root causes and development mechanisms, the wheel–rail impacts, the fatigue failure of vehicle-track parts, and the loss of ride comfort due to rail corrugation should also be taken into account. However, the influences of rail corrugation on vehicle and track vibration, and failure of vehicle and track structural parts are barely discussed in the literature. This paper presents an experimental and numerical investigation of the structural vibration of metro bogies caused by rail corrugation. Extensive experiments are conducted to investigate the effects of short-pitch rail corrugation on the vibration accelerations of metro bogies. A dynamic model of a metro vehicle coupled with a concrete track is established to study the influence of rail corrugation on the structural vibration of metro bogies. The field test results indicate that the short-pitch rail corrugation generates strong vibrations on the axle-boxes and the bogie frames, therefore, accelerates the fatigue failure of the bogie components. The numerical results show that short-pitch rail corrugation may largely reduce the fatigue life of the coil spring, and improving the damping value of the primary vertical dampers is likely to reduce the strong vibration induced by short-pitch rail corrugation. This research systematically studies the effect of rail corrugation on the vibration of metro bogies and proposes some remedies for mitigating strong vibrations of metro bogies and reducing the incidence of failure in primary coil springs, which would be helpful in developing new metro bogies and track maintenance procedures. | LING Liang LI Wei FOO Elbert WU Lei WEN Zefeng JIN Xuesong | 2017 | Chinese Journal of Mechanical Engineering2017，30，1： | 8 |
| 4 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 5 | Capecitabine with radiation is an effective adjuvant therapy in gastric cancers显示文摘AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric cancers.METHODS:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were reviewed.Treatment outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric cancers.RESULTS:A total of 108 patients were reviewed.Median age at diagnosis was 60.The majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 gastrectomy.Twenty one patients(19.4%) had positive surgical resection margins.Thirty three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy alone.For the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 patients.Median recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers. | Chee Kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey Tan Michael Lian Chek Wang Kian Fong Foo | 2010 | World Journal of Gastroenterology2010，16，29： | 6 |
| 6 | Benign prostatic hyperplasia and male lower urinary symptoms:A guide for family physicians显示文摘Male patients with lower urinary tract symptoms(LUTS)and benign prostatic hyperplasia(BPH)are increasingly seen by family physicians worldwide due to ageing demographics.A systematic way to stratify patients who can be managed in the community and those who need to be referred to the urologist is thus very useful.Good history taking,physical examination,targeted blood or urine tests,and knowing the red flags for referral are the mainstay of stratifying these patients.Case selection is always key in clinical practice and in the setting of the family physician.The best patient to manage is one above 40 years of age,symptomatic with nocturia,slower stream and sensation of incomplete voiding,has a normal prostatespecific antigen level,no palpable bladder,and no haematuria or pyuria on the labstix.The roles of α blockers,5-α reductase inhibitors,and antibiotics in a primary care setting to manage this condition are also discussed. | Farhad Fakhrudin Vasanwala Michael Yuet Chen Wong Henry Sun Sien Ho Keong Tatt Foo | 2017 | Asian Journal of Urology2017，4，3： | 5 |
| 7 | Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis显示文摘BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal condition.Research has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(H.pylori)in IBS.This study therefore aimed to provide the first systematic review and meta-analysis on the association between H.pylori infection and IBS.AIM To investigate the association between H.pylori infection and IBS.METHODS Using the keywords“H.pylori OR Helicobacter OR Helicobacter pylori OR infection”AND“irritable bowel syndrome OR IBS”,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June 2018.Attempts were also made to search grey literature.RESULTS A total of 13 clinical studies were systematically reviewed and nine studies were included in the final meta-analysis.Random-effects meta-analysis found a slight increased likelihood of H.pylori infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd ratios.H.pylori eradication therapy also does not appear to improve IBS symptoms.Although publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and H.pylori infection.Further rigorous and detailed studies with larger sample sizes and after H.pylori eradication therapy are warranted. | Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh Wee Song Yeo | 2019 | World Journal of Gastroenterology2019，25，37： | 5 |
| 8 | Comparative studies of versatile extracellular proteolytic activities of lactic acid bacteria and their potential for extracellular amino acid productions as feed supplements显示文摘Background:Increasing understanding on the functions of amino acids (AA) has led to new commercial applications and expansion of the worldwide markets.However,the current technologies rely heavily on non-food grade microorganism and chemical synthesis for the production of AA.Several studies reported that lactic acid bacteria (LAB) have the capability of producing AA owing to their well-established proteolytic system and amino acid biosynthesis genes.Hence,the objectives of this study were to explore the extracellular proteolytic activity of LAB isolated from various Malaysian fermented foods and their potential to produce AA extracellularly as feed supplements.Results:All the studied LAB isolates were versatile extracellular protease producers,whereby extracellular protease activities were detected from acidic to alkaline pH (pH 5,pH 6.5,pH 8) using qualitative and quantitative proteolytic assays.The highest proteolytic activity at pH 5 (15.76 U/mg) and pH 8 (19.42 U/mg) was achieved by Lactobacillus plantarum RG14,while Lactobacillus plantarum RS5 exhibited the highest proteolytic activity of 17.22 U/mg at pH 6.5.As for the results of AA production conducted in de Man,Rogosa and Sharpe medium and analysed by high pressure liquid chromatography system,all LAB isolates were capable of producing an array of AA.Generally,Pediococcus sp.showed greater ability for AA production as compared to Lactobacillus sp.Moreover,the studied LAB were able to produce a few major feed supplement AA such as methionine,lysine,threonine and tryptophan.P.pentosaceus TL-3 recorded the highest methionine and threonine productivity of 3.72 mg/L/h and 5.58 mg/L/h respectively.However,L.plantarum I-UL4 demonstrated a lysine productivity of 1.24 mg/L/h,while P.acidilactici TP-6 achieved up to 1.73 mg/L/h of tryptophan productivity.Conclusion:All the 17 studied LAB isolates possessed versatile extracellular proteolytic system and have vast capability of producing various amino acids including a few major feed supplement AA such as methionine,lysine,threonine and tryptophan.Despite AA production was strain dependent,the studied LAB isolates possessed vast potential and can be exploited further as a bio-agent or an alternative amino acids and bioactive peptide producers. | Ye Heng Lim Hooi Ling Foo Teck Chwen Loh Rosfarizan Mohamad Norhani Abdullah | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 5 |
| 9 | Clinical outcomes of elderly South-East Asian patients in primary percutaneous coronary intervention for ST- elevation myocardial infarction显示文摘评估临床的特征和经历主要经皮的冠的干预(PPCI ) 的老东南亚洲病人的在里面医院结果 .MethodsFrom 2009 年 1 月到 2012 年 12 月, 1268 个病人(86.4% 男性, 58.4 楴 的吝啬的年龄? | Jieli Tong Wen Wei Xiang An Shing Ang Wen Jun Sim Kien Hong Quah David Foo Paul Jau Lueng Ong Hee Hwa Ho | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 10 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 11 | Can intravesical prostatic protrusion predict bladder outlet obstruction even in men with good flow?显示文摘Objective:Men with benign prostate hyperplasia(BPH)with good urinary flow may still have bladder outlet obstruction(BOO).Intravesical prostatic protrusion(IPP)has been shown to be able to predict BOO.We aim to investigate the use of IPP to predict BOO in men with good urinary flow.Methods:One hundred and fourteen consecutive men(>50 years old)presenting with lower urinary tract symptoms suggestive of BPH were recruited in 2001 and 2002.They were evaluated with serum prostate specific antigen(PSA),uroflowmetry and transabdominal ultrasound measurement of IPP and prostate volume(PV).Pressure-flow urodynamic studies were performed on all men and BOO was defined by BOO index>40.Men with Qmax12.0 mL/s were considered to have good flow.Results:Among the 114 men,61 patients had good urinary flow.Their median age,PV and Qmax were 66 years,32.9 mm3 and 14.5 mL/s respectively.14/61(23.0%)patients had BOO and their distribution of IPP were as follows:Grade 1 e 0/20(0%)obstructed,Grade 2 e 6/22(27.3%)and Grade 3 e 8/19(42.1%).Sensitivity of Grade 2/3 IPP for BOO was 100% while specificity of Grade 3 IPP was 76.6%.The area-under-curve(AUC)for IPP was greater than that for PV(0.757 vs.0.696).Conclusion:Even in men with good flow,high grades of IPP were more likely to have BOO and hence,may be a useful adjunct to predict BOO. | Alvin Lee Han Jie Lee Kok Bin Lim Hong Hong Huang Henry Ho Keong Tatt Foo | 2016 | Asian Journal of Urology2016，3，1： | 4 |
| 12 | Adjuvant therapy for gastric cancer:Current and future directions显示文摘The management of gastric cancer continues to evolve. Whilst surgery alone is effective when tumours present early,a large proportion of patients are diagnosed with loco-regionally advanced disease,resulting in high locoregional and distant relapse rates,with subsequent poor survival. Early attempts at improving outcomes following resection were disappointing;however,randomized trials have now established either post-operative chemoradiotherapy(INT0116) or peri-operative chemotherapy as standard adjuvant therapies in the Western world. There remain,however,significant differences in the approach to management between the West and East. In Asia,where there is the highest incidence of gastric cancer,extended resection followed by adjuvant chemotherapy represents the standard of care. This review discusses current standard adjuvant therapy in gastric adenocarcinoma,as well as recent and ongoing trials investigating novel(neo)adjuvant approaches,which hope to build on the successes of previous studies. | Marcus Foo Trevor Leong | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 13 | Is colonic lavage a suitable alternative for left-sided colonic emergencies?显示文摘BACKGROUND The use of intra-operative colonic lavage(IOCL)with primary anastomosis remains controversial in the emergency left-sided large bowel pathologies,with alternatives including Hartmann’s procedure,manual decompression and subtotal colectomy.AIM To compare the peri-operative outcomes of IOCL to other procedures.METHODS Electronic databases were searched for articles employing IOCL from inception till July 13,2020.Odds ratio and weighted mean differences(WMD)were estimated for dichotomous and continuous outcomes respectively.Single-arm meta-analysis was conducted using DerSimonian and Laird random effects.RESULTS Of 28 studies were included in this meta-analysis,involving 1142 undergoing IOCL,and 634 other interventions.IOCL leads to comparable rates of wound infection when compared to Hartmann’s procedure,and anastomotic leak and wound infection when compared to manual decompression.There was a decreased length of hospital stay(WMD=-7.750;95%CI:-13.504 to-1.996;P=0.008)compared to manual decompression and an increased operating time.Single-arm meta-analysis found that overall mortality rates with IOCL was 4%(CI:0.03-0.05).Rates of anastomotic leak and wound infection were 3%(CI:0.02-0.04)and 12%(CI:0.09-0.16)respectively.CONCLUSION IOCL leads to similar rates of post-operative complications compared to other procedures.More extensive studies are needed to assess the outcomes of IOCL for emergency left-sided colonic surgeries. | Hui Yu Tham Wen Hui Lim Sneha Rajiv Jain Cheng Han Mg Snow Yunni Lin Jie Ling Xiao Fung Joon Foo Kar Yong Wong Choon Seng Chong | 2021 | World Journal of Gastrointestinal Surgery2021，13，4： | 3 |
| 14 | Enhance of TiO_2 dopants incorporated reduced graphene oxide via RF magnetron sputtering for efficient dye-sensitised solar cells显示文摘In particular, the dye-sensitised solar cells(DSSCs) have a high potential in the rational energy conversion efficiency to secure our sustainable energy source.In the present study, advanced radio frequency(RF) magnetron sputtering technique was applied to incorporate titanium dioxide(TiO_2) dopants into reduced graphene oxide(rGO) nanosheet for improving the power conversion efficiency(PCE) of DSSCs device. An optimum TiO_2 content incorporated onto rGO nanosheet plays an important role in improving the PCE of DSSCs by minimising the recombination losses of photo-induced charge carriers.Based on the results obtained, 40-s sputtering duration for incorporating TiO_2 dopants onto rGO nanosheet exhibits a maximum PCE of 8.78% than that of pure rGO film(0.68%). In fact, the presence of optimum content of TiO_2 dopants within rGO nanosheet could act as mediators for efficient separation photo-induced charge carriers. However, the excessive of sputtering duration(e.g. 60 s) of TiO_2 dopants onto rGO nanosheet results higher charge recombination and lowers the PCE of DSSCs(5.39%). | Foo Wah Low Chin Wei Lai Kian Mun Lee Joon Ching Juan | 2018 | Rare Metals2018，37，11： | 3 |
| 15 | 妊娠前心血管功能与先兆子痫及胎儿生长受限的关系显示文摘妊娠期间的子痫前期和胎儿生长受限与后期母亲心血管病风险增加有关。目前尚不清楚这种关联是因果关系还是由类似的事先存在的风险因素导致。澄清这种关联需要在受孕前征募研究对象,但在方法上是困难的。 | Foo FL Mahendru AA Masini G Fraser A Cacciatore S MacIntyre DA McEniery CM Wilkinson IB Bennett PR Lees CC 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，8： | 3 |
| 16 | Insights into the modeling of adsorption isotherm systems显示文摘 | K.Y. Foo B.H. Hameed | 2009 | Chemical Engineering Journal2009，，1： | 2 |
| 17 | Efficient solvent extraction of antioxidant-rich extract from a tropical diatom,Chaetoceros calcitrans (Paulsen) Takano 1968显示文摘Objective: To compare the in vitro antioxidant capacity of a diatom, Chaetoceros calcitrans(C. calcitrans) extracted using six types of solvents.Methods: Each extract was evaluated in terms of extraction yield, total carotenoid,fucoxanthin content, total phenolic and antioxidant capacities(DPPH and ABTS +scavenging activity and iron chelating activity).Results: The methanol extract exhibited the highest yield [(22.71 ± 0.96) g/100 g dry weight(DW)], total carotenoid [(4.46 ± 0.36) mg/g DW], total phenolic [(2.49 ± 0.08) mg gallic acid equivalents/g DW] and second highest fucoxanthin content [(2.08 ± 0.03) mg fucoxanthin/g DW] as compared to other solvent extracts. Methanolic extract also exhibited significantly higher(P < 0.05) scavenging(DPPH, ABTS +) and iron chelating activities.Conclusions: Methanol was the recommended solvent for the production of antioxidant rich extract from C. calcitrans. Both carotenoids and phenolic acids were found to be positively correlated to the antioxidant capacities of C. calcitrans. Lead bioactives confirmed by subsequent high performance liquid chromatography studies were fucoxanthin, gallic acid and protocatechuic acid. | Su Chern Foo Fatimah Md.Yusoff Maznah Ismail Mahiran Basri Nicholas Mun Hoe Khong Kim Wei Chan Sook Kun Yau | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 2 |
| 18 | Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G 2 /M cell cycle arrest显示文摘 | Nurdin Armania Latifah Saiful Yazan Siti Noorhidayah Musa Intan Safinar Ismail Jhi Biau Foo Kim Wei Chan Husain Noreen Abdul Hamid Hisyam Said Zulfahmi Maznah Ismail | 2013 | Journal of Ethnopharmacology2013，，2： | 2 |
| 19 | Solving the benign prostatic hyperplasia puzzle显示文摘1.Introduction Benign prostatic hyperplasia(BPH)is a common urological condition,and yet there are many puzzles waiting to be solved.This perspective is to help explain some of these puzzles,based on our recent publications and previous clinical studies on BPH.2.Why small prostates obstruct and some big prostates do not obstruct? | Keong Tatt Foo | 2016 | Asian Journal of Urology2016，3，1： | 2 |
| 20 | Quality indicators in pediatric colonoscopy in a low-volume center:Implications for training显示文摘AIM To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training center.METHODS We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years(January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as benchmarks.RESULTS Median(± SD) age of 121 children [males = 74(61.2%)] who had 177 colonoscopies was 7.0(± 4.6) years. On average, 30 colonoscopies were performed each year(range: 19-58). Except for investigations of abdominal pain(21/177, 17%), indications for colonoscopies were appropriate in the remaining 83%. Bowel preparation was good in 87%. One patient(0.6%) with severe Crohn's disease had bowel perforation. Cecum examination and ileal intubation rate was 95% and 68.1%. Ileal intubation rate was significantly higher in diagnosing or assessing inflammatory bowel disease(IBD) than non-IBD(72.9% vs 50.0%; P = 0.016). Performance of four trainees was consistent throughout the study period. Average cecum and ileal examination rate among trainees were 97% and 77%.CONCLUSION Benchmarking against established guidelines helps units with a low-volume of colonoscopies to identify area for further improvement. | Way-Seah Lee Chun-Wei Tee Zhong-Lin Koay Tat-Seng Wong Fatimah Zahraq Hee-Wei Foo Sik-Yong Ong Shin-Yee Wong Ruey-Terng Ng | 2018 | World Journal of Gastroenterology2018，24，9： | 2 |
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