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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Biologicalmarkers for evaluation of root resorption显示文摘 | Laura B Amsaveni R J ianjun H | 2007 | Arch Oral Biol2007，52，3： | 1 |
| 3 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 4 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 5 | Herbivore effects on plant species density at varying productivity levels显示文摘 | LAURA G GRACE J B | 1998 | Ecology1998，79，5： | 1 |
| 6 | Endothelial cell migration is induced by soluble P-selectin显示文摘 | Lacai M Laura B Harris J et cd | 1998 | Life Science1998，62，1： | 1 |
| 7 | Hyperspectral microwave atmospheric sounding显示文摘 | WILLIAM B J LAURA B J VINCENT L R | | 0，，01： | 1 |
| 8 | Association between high - risk human papilloma virus DNA load and pre - cursor lesions of cervical cancer in Mexican women 显示文摘 | DULCE M H LAURA O B MIRIAM G J | 2003 | Gyne Onco2003，90，： | 1 |
| 9 | Microbial Inactivation by Pulsed Electric Fields in a Batch Treatment Chamber:Effects of Some Electrical Parameters and Food Constituents显示文摘 | MANAS P LAURA B S CHEFTEL C J | 2001 | Food Science & Emerging Technologies2001，2，： | 1 |
| 10 | The state of the art on Wells-Dawson heteropoly-compounds:a review of their properties and applications显示文摘 | LAURA E B GRACIELA T B HORACIO J T | 2003 | Applied Catalysis A:General2003，256，： | 1 |
| 11 | Wolbachia:master manipulators of invertebrate biology显示文摘 | Werren J H Laura B Clark M E | 2008 | Nature Reviews Microbiology2008，6，10： | 1 |
| 12 | Lawton:Residents pereeptions in the urban-rural fringe显示文摘 | WEAVER DAVID B LAURA J | 2001 | Annal of Tourism Research2001，28，2： | 1 |
| 13 | The state of the art on Wells - Dawson heteropoly - compounds: A review of their properties and applications 显示文摘 | Laura E B Graciela T B Horacio J T | 2003 | Applied Catalysis A :2003，256，： | 1 |
| 14 | A Required third-year medical student palliative care curriculum impacts knowledge and attitudes显示文摘 | Laura J Morrison B Thompson M | 2012 | J Palliative Med2012，15，7： | 1 |
| 15 | Association belwen high risk human papillomarirus DNA load and precursor Lesions of lervical cancer in Mexican women显示文摘 | DULEE M H LAURA O B MIRIAM G J | 2003 | Gyno Onco2003，90，： | 1 |
| 16 | Two - stage coalescence in double emulsions 显示文摘 | HECTOR G O LAURA I B ARAUZLARA J | 2003 | Langmuir2003，19，： | 1 |
| 17 | Endogenous mechanisms of neuroprotection : role of zinc, copper, and carnosine 显示文摘 | Michelle S H Laura J B Paul Q T | 2000 | Brain Research2000，852，： | 1 |
| 18 | Resident Perceptionsin the Urban-Rural Fringe 显示文摘 | David B Weaver Laura J Lawton | 2001 | Annals of Tourism Re-search2001，28，2： | 1 |
| 19 | Creativity and the five-factor model显示文摘 | Laura A K Lori M W Sheri J B | 1996 | Journal of Research in Personality1996，，30： | 1 |
| 20 | Creativity and thefive-factor model显示文摘 | Laura AK Lori MW Sheri J B | 1996 | Journal of Research in Personality1996，30，： | 1 |
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