|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 3 | Diagnosis in bile acid-CoA:Amino acid N-acyltransferase deficiency显示文摘Cholate-CoA ligase(CCL) and bile acid-CoA:amino acid N-acyltransferase(BAAT) sequentially mediate bile-acid amidation.Defects can cause intrahepatic cholestasis.Distinction has required gene sequencing.We assessed potential clinical utility of immunostaining of liver for CCL and BAAT.Using commercially available antibodies against BAAT and CCL,we immunostained liver from an infant with jaundice,deficiency of amidated bile acids,and transcription-terminating mutation in BAAT.CCL was normally expressed.BAAT expression was not detected.Immunostaining may facilitate diagnosis in bileacid amidation defects. | Nedim Hadzi Laura N Bull Peter T Clayton AS Knisely | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 4 | Greenhouse gas emissions from the Tubul-Raqui estuary (central Chile 36°S)显示文摘 | Inger Daniel Michael DeGrandpre Laura Farías | 2013 | Estuarine, Coastal and Shelf Science2013，，： | 1 |
| 5 | Physiological Roles of Mitochondrial Reactive Oxygen Species 显示文摘 | Laura AS Navdeep SC | 2012 | Molecular Cell2012，48，2： | 1 |
| 6 | SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation显示文摘 | Gergana Dobreva Maria Chahrour Marcel Dautzenberg Laura Chirivella Benoit Kanzler Isabel Fari?as Gerard Karsenty Rudolf Grosschedl | 2006 | Cell2006，，5： | 1 |
| 7 | Adiposity,muscle mass,and muscle strength in relation to functional decline in older per- sons显示文摘 | Laura AS Annemarie K Marjolein V | 2012 | Epidemiol Rev2012，，： | 1 |
| 8 | Relationship of fibrinogen levels and hemostatic abnormalities with organ damage in hypertension显示文摘 | Leonardo AS Laura Z Cristiana C | 2000 | Hypertension2000，36，： | 1 |
| 9 | Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease显示文摘 | José L. Pérez-Castrillón Gemma Vega Laura Abad Alberto Sanz José Chaves Gonzalo Hernandez Antonio Due?as | 2007 | The American Journal of Cardiology2007，，7： | 1 |
| 10 | Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis显示文摘 | Laura Pina-Camacho Angel Del Rey-Mej i as Joost Janssen | 2016 | Schizophrenia Bulletin2016，42，2： | 1 |
| 11 | Phylogenetic analysis reveals the emergence,evolution and dispersal of carnivore Parvoviruses显示文摘 | Karin Laura AS Colin RP | 2008 | Journal of General Virology2008，89，9： | 1 |
| 12 | Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis显示文摘 | Andréa Diniz Laura Escuder-Gilabert Norberto P. Lopes Rosa María Villanueva-Cama?as Salvador Sagrado María José Medina-Hernández | 2008 | Analytical and Bioanalytical Chemistry2008，，2： | 1 |
| 13 | Low and very low birth weight in infants conceived with use of assisted reproductive technology显示文摘 | Susan FM Cynthia F | 2002 | N Engl J Med2002，346，10： | 1 |
| 14 | Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?显示文摘BACKGROUND Different forms of pregenomic and other hepatitis B virus(HBV)RNA have been detected in patients’sera.These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity,and predicting hepatitis B eantigen seroconversion or viral rebound after nucleos(t)ide analog cessation.Data on serum HBV-RNA quasispecies,however,is scarce.It is therefore important to develop methodologies to thoroughly analyze this quasispecies,ensuring the elimination of any residual HBV-DNA.Studying circulating HBV-RNA quasispecies may facilitate achieving functional cure of HBV infection.AIM To establish a next-generation sequencing(NGS)methodology for analyzing serum HBV-RNA and comparing it with DNA quasispecies.METHODS Thirteen untreated chronic hepatitis B patients,showing different HBV-genotypes and degrees of severity of liver disease were enrolled in the study and a serum sample with HBV-DNA>5 Log10 IU/mL and HBV-RNA>4 Log10 copies/mL was taken from each patient.HBV-RNA was treated with DNAse I to remove any residual DNA,and the region between nucleotides(nt)1255-1611 was amplified using a 3-nested polymerase chain reaction protocol,and analyzed with NGS.Variability/conservation and complexity was compared between HBV-DNA and RNA quasispecies.RESULTS No HBV-DNA contamination was detected in cDNA samples from HBV-RNA quasispecies.HBV quasispecies complexity showed heterogeneous behavior among patients.The Rare Haplotype Load at 1%was greater in DNA than in RNA quasispecies,with no statistically significant differences(P=0.1641).Regarding conservation,information content was equal in RNA and DNA quasispecies in most nt positions[218/357(61.06%)].In 102 of the remaining 139(73.38%),HBV-RNA showed slightly higher variability.Sliding window analysis identified 4 hyper-conserved sequence fragments in each quasispecies,3 of them coincided between the 2 quasispecies:nts 1258-1286,1545-1573 and 1575-1604.The 2 hyper-variable sequence fragments also coincided:nts 1311-1344 and 1461-1485.Sequences between nts 1519-1543 and 1559-1587 were only hyper-conserved in HBV-DNA and RNA,respectively.CONCLUSION Our methodology allowed analyzing HBV-RNA quasispecies complexity and conservation without interference from HBV-DNA.Thanks to this,we have been able to compare both quasispecies in the present study. | Selene Garcia-Garcia Maria Francesca Cortese David Tabernero Josep Gregori Marta Vila Beatriz Pacín Josep Quer Rosario Casillas Laura Castillo-Ribelles Roser Ferrer-Costa Ariadna Rando-Segura Jesús Trejo-Zahínos Tomas Pumarola Ernesto Casis Rafael Esteban Mar Riveiro-Barciela Maria Buti Francisco Rodríguez-Frías | 2021 | World Journal of Gastroenterology2021，27，41： | 1 |
| 15 | HPLC -F analysis of me- latonin and resveratrol isomers in wine using an SPE procedure 显示文摘 | Laura M Maria AS Francesca B | 2008 | J Separ Sci2008，31，67： | 1 |
| 16 | Effect of several cryoprotectants on thephysico chemical and rheological properties of suwari gels from frozen squid surimi made by two methods显示文摘 | Laura Campo-Dea(n)o Clara A Tovar Javier Borderías | | 0，，： | 1 |
| 17 | Neural correlates of the severity of cocaine,heroin,alcohol,MDMA and cannabis use in polysubstance abusers:a resting-PET brain metabolism study显示文摘 | Laura ML Emmanuel AS Maria JFS | | 0，，6： | 1 |
| 18 | The erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of δ-catenin and ARVCF显示文摘 | Laura RP Witt AS Held HA | 2002 | J Biol Chem2002，277，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员