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| 1 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 2 | Hepatitis B and human immunodeficiency virus co-infection显示文摘Hepatitis B and human immunodeficiency virus(HBV and HIV)infection share transmission patterns and risk factors,which explains high prevalence of chronic HBV infection in HIV infected patients.The natural course of HBV disease is altered by the HIV infection with less chance to clear acute HBV infection,faster progression to cirrhosis and higher risk of liver-related death in HIVHBV co-infected patients than in HBV mono-infected ones.HIV infected patients with chronic hepatitis B should be counseled for liver damage and surveillance of chronic hepatitis B should be performed to screen early hepatocellular carcinoma.Noninvasive tools are now available to evaluate liver fibrosis.Isolated hepatitis B core antibodies(anti-HBc)are a good predictive marker of occult HBV infection.Still the prevalence and significance of occult HBV infection is controversial,but its screening may be important in the management of antiretroviral therapy.Vaccination against HBV infection is recommended in non-immune HIV patients.The optimal treatment for almost all HIV-HBV co-infectedpatients should contain tenofovir plus lamivudine or emtricitabine and treatment should not be stopped to avoid HBV reactivation.Long term tenofovir therapy may lead to significant decline in hepatitis B surface Antigen.The emergence of resistant HBV strains may compromise the HBV therapy and vaccine therapy. | Bao-Chau Phung Philippe Sogni Odile Launay | 2014 | World Journal of Gastroenterology2014，20，46： | 6 |
| 3 | Study of new catalysts based on vanadium oxide supported on mesoporous silica for the partial oxidation of methane to formaldehyde:Catalytic properties and reaction mechanism显示文摘 | NGUYEN L D LORIDANT S LAUNAY H PIGAMO A DUBOIS J L MILLET J M | | 0，，01： | 1 |
| 4 | Pulmonary manifestations of Sjogren's syndrome显示文摘 | Hatron PY Tillie-Leblond I Launay D | | 0，，1： | 1 |
| 5 | Antiviral drug- induced nephrotoxicity 显示文摘 | Izzedine H Launay Vacher V Deray G | 2005 | Am J Kidney Dis2005，45，5： | 1 |
| 6 | Characterization of discriminant human brain antigenic targets in neuropsychiatric systemic lupus erythematosus using an immunoproteomic approach显示文摘 | Lefranc D Launay D Dubucquoi S | 2007 | Arthritis Rheum2007，56，10： | 1 |
| 7 | Annual migration of Houbara BustardChlamydotis undulata macqueenii from the United Arab Emirates 显示文摘 | Launay F Combreau O Bowardi M A | 1999 | Bird Conservation International1999，9，： | 1 |
| 8 | TRPM4, Ca2 ~ -activated nonselective cation channel in mouse sino-atrial node cells 显示文摘 | Demion M Bois P Launay P | 2007 | Cardiovasc Res2007，73，3： | 1 |
| 9 | A 'one-pot' syn- thesis of adipic acid from cyclohexene under mild condi- tions with new bifunctional Ti-A1SBA mesostructured cata- lysts 显示文摘 | Lapisardi G Chiker F Launay F | 2004 | Catal Commun2004，5，6： | 1 |
| 10 | Pulmonary involvement in Sweet's syndrome: a case report andreview of the literature 显示文摘 | Astudillo L Sailler L Launay F | 2006 | Int J Dermatol2006，45，： | 1 |
| 11 | Immunosuppressive therapy in lupus-and mixed connective tissue disease-associated pulmonary arterial hypertension:a retrospective analysis of twenty-three cases显示文摘 | Jais X Launay D Yaici A | 2008 | Arthritis Rheum2008，58，2： | 1 |
| 12 | Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial 显示文摘 | Launay O Sadorge C Jolly N | 2009 | Vaccine2009，27，8： | 1 |
| 13 | Activity rhythms of houbara bustard (Chlamydotis undulata macqueenii) in relation to some abiotic factors显示文摘 | Combreau O Launay F | 1996 | Journal of Arid Environemnts1996，33，： | 1 |
| 14 | Sintering and phase transformation of V-loaded anatase materials containing bulk and surface V species 显示文摘 | Balikdjian J P Davidson A Launay S | 2000 | Journal of Physical Chemistry B2000，104，： | 1 |
| 15 | Preliminary observation of the incubation and covey behaviour of houbara bustard Chlamydotis undulata macqueenii显示文摘 | Launay F Loughland R A Mukhina E | 1997 | Sandgrouse1997，19，1： | 1 |
| 16 | Electron delocalization in mixed-valence molybdenum polyanions显示文摘 | Sanchez C Livage J Launay J P | 1982 | J Am Chem Soc1982，104，： | 1 |
| 17 | Determi- nants of disease presentation and outcome during cryptococ- cosis : the CryptoA/D study 显示文摘 | Dromer F Mathoulin-Pelissier S Launay O | 2007 | PLos Med2007，4，2： | 1 |
| 18 | Hypertrophic cranial pachymeningitis in countries endemic for tubercu- losis : diagnostic and therapeutic dilemmas 显示文摘 | Bosman T Simonin C Launay D | 2008 | Clin Neurosci2008，15，4： | 1 |
| 19 | High Catalytic Cracking Activity of Al-MCM-41 Type Materials Prepared from ZSM-5Zeolite Crystals and Fumed Silica显示文摘 | Sami Habib Franck Launay Sebastien Laforge | 2008 | Applied Catalysis A:General2008，，344： | 1 |
| 20 | Three-dimensional electron microscopy of entire cells显示文摘 | Bron C Gremille P Launay D | 1990 | J Microsc1990，157，1： | 1 |
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