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| 1 | 藿香和广藿香挥发油对皮肤癣菌和条件致病真菌的抑制作用显示文摘目的 :筛选天然抗皮肤真菌新药和开发芳香油植物资源。方法 :利用培养基药物浓度稀释法和气相色谱 质谱联用技术 ,研究了藿香和广藿香挥发油对 12种皮肤癣菌和条件致病真菌的体外抑制作用和主要化学成分 ,比较了 3种不同地理来源(中国、印度和印度尼西亚爪哇 )广藿香油的抗真菌活性。结果 :这 4种挥发油都可以选择性地完全抑制皮肤癣菌的生长繁殖 ,其中中国广藿香油的活性最强 ,其最低抑制浓度 (MIC) 5 0~ 4 0 0 μl·L-1,主要化学成分为广藿香醇、异愈创木烯和广藿香烯。藿香油最弱 ,MIC位于 70 0~ 10 0 0 μl·L-1,主要成分是薄荷酮类化合物。结论 :证明了广藿香油的选择性皮肤癣菌抑制作用 ,为进一步筛选抗真菌外用新药提供了重要依据。 | 杨得坡 Chaumont Jean-Pierre Millet Jolle | 2000 | 中国药学杂志2000，35，1： | 75 |
| 2 | 黄芩甙元和黄芩甙对皮肤真菌与细菌抑制作用的研究显示文摘本文研究了黄芩甙和黄芩甙元对十七种皮肤致病真菌与十六种皮肤细菌的抑制活性。在琼脂药物培养基上,黄芩甙元表现出了对酵母型真菌高度的选择抑制作用,其最低抑制浓度MIC在70~100μg/ml之间,而对皮肤癣菌和丝状霉菌没有活性;黄芩甙则对所有的供试真菌几乎没有作用。另外,与脚气和腋臭有关的负责菌如固着微球菌、表皮葡萄球菌、人型葡萄球菌和干燥棒杆菌等,在黄苓甙元浓度为250μg/ml的条件下,其生长繁殖也能完全抑制。黄芩甙元的抗菌活性可能与其结构第七位羟基的存在有关。 | 杨得坡 胡海燕 黄世亮 Jean-Pierre Chaumont Joělle Millet | 2000 | 中药材2000，23，5： | 64 |
| 3 | 花椒毒素在人体皮肤及角质层中的渗透动力学探讨显示文摘目的探讨花椒毒素在人体完整皮肤及其角质层中的渗透动力学特性。方法采用人体离体皮肤及从完整皮肤中分离出的角质层,在Franz-cell扩散池中进行不同浓度的花椒毒素乙醇溶液(0.1,0.5,2.5和5.0 mg.mL-1)的渗透实验,均采用1.4%的人血清溶液作为接收液,用HPLC法测定各接收液的药物量和皮肤中的贮存药物量。结果花椒毒素乙醇溶液单位面积透过完整人皮肤速率随着浓度增加而增加,2.5 mg.mL-1以上的浓度对其速率几乎无影响。在角质层中也存在同样的现象,但其单位面积透皮速率最大值提前了约6 h。而且随着给药浓度的增加,24 h后完整皮肤和角质层的药物贮存量也相应增加,但达到一定浓度后存在饱和现象。且花椒毒素乙醇溶液在完整皮肤中的透皮时滞(0.82 h)明显大于在角质层中的透皮时滞(0.47 h)。结论该结果对开发花椒毒素外用制剂时浓度的选择提供了依据,并对其外用药物后照射长波段紫外光(UVA)的时间提供了参考。 | 王来友 Jelle Millet 黄芳芳 杨得坡 | 2006 | 药学学报2006，41，9： | 10 |
| 4 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 5 | 角蛋白酶在真菌侵染皮肤过程中的作用显示文摘具有高度交联三维结构的角蛋白对各种物理、化学和一般性的蛋白水解酶攻击具有很强的抗性,但在底物的诱导下,皮肤真菌分泌的用蛋白酶可特异性地水解该蛋白。在真菌感染皮肤过程中,用蛋白酶与菌丝的机械侵入和化学还原作用配合,使病原菌获得营养和侵入皮肤。在抗真菌药物的配方中,加入角蛋白酶,可帮助活性因子通过皮肤屏障或抑制病原菌繁殖。 | 杨得坡 Jean-Pierre Chaumont 彭劲甫 王发松 Joёlle Millet | 2000 | 微生物学杂志2000，20，2： | 3 |
| 6 | 短期常压低氧步行训练对肥胖成年人运动能力和步态的影响显示文摘为了比较以个人喜好的步行速度(preferred walking speed,PWS)短期低氧与常氧训练对肥胖患者的能量、力学、效率和代谢风险标志物的影响,Fernández Menéndez等纳入肥胖患者23例,在缺氧[海拔3km,n=12;体质量指数(body mass index,BMI)(34.0±0.8)kg/m2]或常氧[海拔360m,n=11;BMI(32.9±0.8)kg/m2]情况下. | 刘青 叶鹏 Fernández Menéndez A Saudan G Sperisen L Hans D Saubade M Millet GP Malatesta D | 2018 | 中华高血压杂志2018，26，6： | 2 |
| 7 | Electrochemical behaviour of chemically lithiated LixV2O5 phases显示文摘 | MILLET M PEREIRA-RAMOS T P | 1999 | Power Sources1999，8182，： | 1 |
| 8 | Gadolinium ion is the inhibitor suitable for testing the putative role of stretch-activated ion channels in geotropism and thigmotropism显示文摘 | Millet B Pickard BG | 1988 | Biophys J1988，53，： | 1 |
| 9 | Electrochemical sodium insertion into MnCo oxide显示文摘 | BACH S MILLET M PERIERA-RAMOS J P | 1999 | Electrochemical and Solid-State Letters1999，2，： | 1 |
| 10 | Metastasis of the gallbladder in clear cell renal carcinoma显示文摘 | Robledo AB Millet SB Orbis Castellanos JF | 2012 | Oncol Lett2012，3，5： | 1 |
| 11 | Study on the use of omega-3 fatty acids as a therapeutic supplement in treatment of psoriasis显示文摘 | Balb6s GM Regafia MS Millet PU | 2011 | Clinical Cosmetic Investigational Dermatology2011，4，： | 1 |
| 12 | Study of new catalysts based on vanadium oxide supported on mesoporous silica for the partial oxidation of methane to formaldehyde:Catalytic properties and reaction mechanism显示文摘 | NGUYEN L D LORIDANT S LAUNAY H PIGAMO A DUBOIS J L MILLET J M | | 0，，01： | 1 |
| 13 | The role of vanadium on the properties of iron based catalysts for the water gas shift reaction 显示文摘 | Ivan Lima Junion Jean-Marc M Millet Mimoum Aouine | 2005 | Applied catalysis A2005，283，12： | 1 |
| 14 | Polymorphism in Plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9,10-dihydroethanoanthracene derivative显示文摘 | Millet J Alibert S Torrentino-Madamet M | 2004 | Antimicrob Agents Chemother2004，48，12： | 1 |
| 15 | Direct visualization of perforationsites in patients with a non-traumatic free pneumoperitoneum:added diagnostic value of thin transverse slices amd coronal andsagittal reformations for multi-detecor显示文摘 | Ghekiere O Lesnik A Millet I | 2007 | Eur Radiol2007，17，9： | 1 |
| 16 | Lipase-catalyzed reactions in organic media: Competition and applications 显示文摘 | Deleuze H Langrand G Millet H | 1987 | Biochimica et Biophysica Aeta (BBA)-Protein Strueture and Molecular Enzymology1987，911，1： | 1 |
| 17 | Fibro-osseouslesions invol-ving the brain : MRI显示文摘 | Shfier DA Melville D Millet D | 1999 | Neuroradiology1999，41，1： | 1 |
| 18 | A Negative Feedback Control of Transforming Growth Factor-Signaling by Glycogen Synthase Kinase 3 - mediated Smad3 Linker Phosphorylation at Ser-204显示文摘 | Millet C Yamashita M Heller M | 2009 | 1 BioI Chem2009，284，19： | 1 |
| 19 | Formation of Gallium Nitride by a Novel Hot Mechanical Alloying Process显示文摘 | Millet P Calka A Williams J S | 1993 | Appl Phys Lett1993，63，： | 1 |
| 20 | J Catal显示文摘 | Kumbhar P S Sanchez-Valente J Millet J M Figueras F | 2000 | 2000,191 (2) :4672000，191，2： | 1 |
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