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| 1 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 2 | Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice显示文摘 | DIKALOVA A CLEMPUS R LASSGUE B | 2005 | Circulation2005，112，： | 1 |
| 3 | Electron transport-linked ubiquinonedependent recycling of a-tocopherol inhibits autooxidation of mitochondrial membranes显示文摘 | Lass A Sohal R S | 1998 | Arch Biochem Biophys1998，352，： | 1 |
| 4 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 5 | Defective lipolysisand altered energy metabolism in mice lacking adipose triglyceridelipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 6 | Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome 显示文摘 | LASS A ZIMMERMANN R HAEMMERLE G | 2006 | Cell Metab2006，3，5： | 1 |
| 7 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 8 | Effect oflifestyle intervention on features of polycystic ovarian syndrome,metabolic syndrome,and intima-media thickness in obeseadolescent girls显示文摘 | Lass A Kleber M Winkel K Wunsch R Reinehr T | 2011 | J Clin Endocrinol MeTab2011，96，11： | 1 |
| 9 | Exer- cise capacity, daily activity, and severity of fatigue in term born young adults after neonatal respiratory failure 显示文摘 | van der Cammen-van Zijp MH Spoel M Lass R | 2014 | Scand J Med Sci Sports2014，24，1： | 1 |
| 10 | Further study of the gas temperature deviation in large-scale tangentially coal-firedboilers显示文摘 | CHUNGEN Y LASSE R THOMAS J C | 2003 | Fuel2003，82，9： | 1 |
| 11 | Adipose triglyc eride lipase-mediated lipolysisof cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome显示文摘 | Lass A Zimmermann R Haemmerle G | 2006 | Cell Metabolism2006，3，5： | 1 |
| 12 | Defective lipolysis and altered energy metabolism in mice laeking adipose triglye eride lipase 显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 13 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase 显示文摘 | HAEMMERLE G LASS A ZIMMERMANN R | 2006 | Science2006，312，： | 1 |
| 14 | Electron transport-linked ubiquinone-dependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes显示文摘 | Lass A and Sohal R S | 1998 | Archives of Biochemistry and Biophysics1998，352，： | 1 |
| 15 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 16 | Burden sharing and fairness principles in international climate policy显示文摘 | Lasse R Asbjorn T Arild U | 2002 | International Environmental Agreements:Politics Law and Economics2002，2，1： | 1 |
| 17 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase 显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 18 | Follicular density in ovarian biopsy of infertile women:a novel method to assess ovarian reserve显示文摘 | Lass A Silye R Abrams DC | | 0，，05： | 1 |
| 19 | Determination of coenzyme Q in human tissue by electrical detector显示文摘 | Lass A Sohal R S | 2000 | Faseb J2000，14，1： | 1 |
| 20 | How to do things with junk : Exaptation in language evolution 显示文摘 | Lass R | 1990 | Journal of Linguistics1990，26，1： | 1 |
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