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| 1 | Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons显示文摘Objective To investigate whether intracellular amyloid β (iAβ) induces toxicity in wild type (WT) and APP/PS1 mice, a mouse model of Alzheimer's disease. Methods Different forms of Aβ aggregates were microinjected into cultured WT or APP/PS1 mouse hippocampal neurons. TUNEL staining was performed to examine neuronal cell death. Reactive oxidative species (ROS) were measured by MitoSOXTM Red mitochondrial superoxide indicator. Results Crude, monomer and protofibrilAβ induced more toxicity inAPP/PS1 neurons than in WT neurons. ROS are involved in mediating the vulnerability of APP/PS1 neurons to iAβ toxicity. Conclusion Oxidative stress may mediate cell death induced by iAβ in neurons. | Bin Yang Xiaqin Sun Hilal Lashuel Yan Zhang | 2012 | Neuroscience Bulletin2012，28，3： | 4 |
| 2 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 3 | The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility显示文摘 | Liu Y Fallon L Lashuel HA | 2002 | Cell2002，111，2： | 1 |
| 4 | New class of inhibitors of amyloid-βfibril formation Implications for the mechanism of pathogenesis in Alzheimer's desease显示文摘 | Lashuel HA Hartley DM Balakhaneh D | 2002 | J Biol Chem2002，277，42： | 1 |
| 5 | A century-old debate on protein aggregation and neurodegeneration enters the clinic 显示文摘 | LANSBURY PT LASHUEL HA | 2006 | Nature2006，443，7113： | 1 |
| 6 | Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?显示文摘 | Lashuel HA Lansbury PT Jr | 2006 | Q Rev Biophys2006，39，： | 1 |
| 7 | Preparation and characterization of toxic Ag aggregates for structural and functional studies in Alzhei- mer's disease research显示文摘 | Jan A Hartley D M Lashuel H A | 2010 | Nat Protoc2010，5，： | 1 |
| 8 | The UGH-L1 gene encodes two opposing enzymatic activities that 'affect alpha-synuelein degradation and Parkinson ' s disease susceptibility 显示文摘 | Liu Y Fallon L lashuel HA etal | 2002 | Cell2002，111，2： | 1 |
| 9 | The UCH-L1 gene encodes two opposing enzymatic activities that affect a-synuclein degradation and Parkinson 's disease susceptibility显示文摘 | Fallon L Lashuel HA | 2002 | Cell2002，111，： | 1 |
| 10 | The many faces of α - synuclein: from structure and toxicity to therapeutic target 显示文摘 | Lashuel HAl Overk CR Oueslati A | 2013 | Nat RevNeurosci2013，14，1： | 1 |
| 11 | Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research显示文摘 | Jan A Hartley D M Lashuel H A | 2010 | Nature Protocols2010，5，6： | 1 |
| 12 | The UCHL1Gene encode two opposing enzymatic activities that affect α-Sy nuclein degradation and Parkinson's disease susceptibility显示文摘 | Liu Y Fallon L Lashuel H A | 2002 | Cell2002，111，： | 1 |
| 13 | Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils显示文摘 | Lashuel HA Petre BM Wall J | 2002 | J Mol Biol2002，322，5： | 1 |
| 14 | Neurodegenerative disease:amyloid pores from pathogenic mutations显示文摘 | Lashuel H A Hartley D Petre B M | 2002 | Nature2002，418，6895： | 1 |
| 15 | The UCH - L1 geneencodes two opposing enzymatic activitiesthat affect alpha - synuclein degradation and Parkinsong disease susceptibility 显示文摘 | Liu Y Fallon L Lashuel H A | 2002 | Cell2002，111，2： | 1 |
| 16 | The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility显示文摘 | Liu Y Fallon L Lashuel HA | 2002 | Cell2002，111，2： | 1 |
| 17 | A century-old debate on protein aggregation and neurodegeneration enters the clinic显示文摘 | Lansbury P T Lashuel H A | | 0，，7113： | 1 |
| 18 | A century old debate on protein aggregation and neurodegeneration enters the clinic显示文摘 | Lansbury PT Lashuel HA | 2006 | Nature2006，443，7113： | 1 |
| 19 | Discovery of inhibitors that e-lucidate the role of UCH-LI activity in the H1299 lung cancer cell line显示文摘 | Liu Y Lashuel HA Choi S | 2003 | Chem Biol2003，10，9： | 1 |
| 20 | Neurodegenerative disease: amyloid pores from pathogenic mutations显示文摘 | Lashuel HA Hartley D Petre BM | 2002 | Nature2002，418，6895： | 1 |
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