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| 1 | Rifaximin vs conventional oral therapy for hepatic encephalopathy:A meta-analysis显示文摘AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le. | Karim M Eltawil Marie Laryea Kevork Peltekian Michele Molinari | 2012 | World Journal of Gastroenterology2012，18，8： | 9 |
| 2 | Human bone marrow stromal cells inhibit allogeneie T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 3 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 4 | Human bone marrow stromal cells inhibit allogenic T-cell response by indoleamine 2,3-dioxygenase mediated tryptophan degradation显示文摘 | Meisei R Zbert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 5 | Human bone marrow stromal cells inhibit allogeneic T -cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 6 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 7 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 8 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation 显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 9 | Human bone marrow stromal cells inhibit allogeneic T - cell responses by indoleamine 2,3 - dioxygenase - mediated tryptophan degradation 显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，： | 1 |
| 10 | Analysis of the fatty acid composition of erythrocyts phospholipids by a base catalysed transesterification method-prevention of formation of dimethylacethals显示文摘 | Laryea M D Cieslicki P Diekmann E | 1988 | Clinica Chemica Acta1988，171，： | 1 |
| 11 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3 dioxygenase mediated tryptophan degradation 显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，： | 1 |
| 12 | Human bone marrow stromal ceils inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，： | 1 |
| 13 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | MEISEL R ZIBERT A LARYEA M | 2004 | Blood2004，103，12： | 1 |
| 14 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation 显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，46： | 1 |
| 15 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，： | 1 |
| 16 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation 显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，46： | 1 |
| 17 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 18 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，，： | 1 |
| 19 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by in- doleamine 2, 3-dioxygenase-mediated tryptophan degradation显示文摘 | Meisel R Zibert A Laryea M | 2004 | Blood2004，103，12： | 1 |
| 20 | Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation显示文摘 | MEISEL R ZIBERT A LARYEA M | 2004 | Blood2004，103，： | 1 |
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