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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 3 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 4 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 5 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005，182，2： | 1 |
| 6 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 7 | Locking plate technology and its applications in upper ex trem ity fracture care显示文摘 | Larson AN R izzo M | 2007 | Hand Clin2007，23，2： | 1 |
| 8 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 9 | The failure syndrome 显示文摘 | LARSON C M R C CLUTE | 1979 | American Journal of Small Business1979，4，2： | 1 |
| 10 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 11 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 12 | Aphroscopic management of femoroacetabular impinge- ment: early outcomes measures 显示文摘 | Larson C M Giveans M R | 2008 | Ar- throseopy2008，24，5： | 1 |
| 13 | Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide,doxorubicin,vincristine,and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lympho显示文摘 | Karmali R Larson M L Wooldridge J E | | 0，，11： | 1 |
| 14 | Selective poisoning and de-activation of acid sites on sulfated zirconia catalysts for n-butane i-somerization显示文摘 | Yaluris G Larson R B Kobe J M | 1996 | Journal of Catalysis1996，158，： | 1 |
| 15 | Man;tging motivation: the impact of supervisor feedback on subordinate task interest显示文摘 | HARACKIEWICZ J M LARSON J R | 1986 | Journal of Personali tyand Social Psychology1986，51，3： | 1 |
| 16 | Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the Fram- ingham Study显示文摘 | Keaney J F Jr Larson M G Vasan R S | 2003 | Aeterioscler Thromb Vasc Biol2003，23，3： | 1 |
| 17 | Oxidative polymerization of dissolved phenols by soluble and insoluble inorganic species 显示文摘 | LARSON R A Hufnal J M | 1980 | Limnology and Oceanography1980，25，2： | 1 |
| 18 | Relationship between age of blastocyst formation and interferon-τ secretion by in vitro-derived bovine embryos 显示文摘 | Kubisch H M Larson M A Roberts R M | 1998 | Mol Reprod Dev1998，49，： | 1 |
| 19 | Plate tectonic reconstructions of the Cretaceous and Cenozoic ocean basins显示文摘 | Scotese C R Gahagan L M Larson R L | 1988 | Tectonophysics1988，155，1234： | 1 |
| 20 | Water-soluble quantum dots for multiphoton fluorescence imaging in vivo 显示文摘 | Daniel R Larson Warren R Zipfel Rebecca M Williams | 2003 | Science2003，300，： | 1 |
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