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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 3 | On the uncertainty of interwell connectivity estimations from the capacitance-resistance model显示文摘The capacitance-resistance model(CRM) is an alternative to conventional reservoir simulation. CRM, a simplification of complex numerical models, uses production and injection rates to infer a reservoir description. There is no prior geologic model. The principal output of CRM fitting is the fraction of injected fluid(usually water) that is produced at a producer at steady-state. These fractions are interwell connectivities. Interwell connectivities are fundamental information needed to manage waterfloods in oil reservoirs. The data-driven CRM is a fast tool to estimate these parameters in mature fields and allows one to make full use of the dynamic data available. This paper considers the problem of setting an upper bound on the uncertainty of interwell connectivities for linear-constrained models. Using analytical bounds and numerical simulations, we derive a consistent upper limit on the uncertainty of interwell connections that can be used to quantify the information content of a given dataset. | Gustavo A Moreno Larry W Lake | 2014 | Petroleum Science2014，11，2： | 3 |
| 4 | An infertile male with dilated seminal vesicles due to functional obstruction显示文摘 | Michael D Font Alexander W Pastuszak John R Case Larry I Lipshult | 2017 | Asian Journal of Andrology2017，19，2： | 2 |
| 5 | PRIMARY CELL CULTURE FOR EMBRYONIC CARDIAC MYOCYTES OF MEXICAN AXOLOTL AND DISTRIBUTION OF DESMIN AND VIMENTIN显示文摘INTRODUCTIONTheaxolotlprovidesavaluablemodelsystemforstudyingmuscledevelopmentandfunction.Electronmicroscopyrevealsthataxolot... | Zhu Yongze, Robert W Zajdel *, Margaret E Fransen *, Larry F Lemanski *(Department of Anatomy, Medical College of Yangzhou University, Yangzhou, 225001 Chian Department of Anatomy and Cell Biology, State University of New York, Health Science Cent | 1999 | 中国组织化学与细胞化学杂志1999，8，1： | 2 |
| 6 | Epidemiology of environmental tobacco smoke exposure 显示文摘 | Ross C Brownson Larry W Figgs Laura E Caisley | 2002 | Oncogene2002，，21： | 1 |
| 7 | Corruption, Political Connections and Municipal Finance 显示文摘 | Butler A W Larry F Sandra M | 2009 | Review of Finance2009，，22： | 1 |
| 8 | Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation显示文摘 | Douglas RS Larry W | 2001 | Cancer Res2001，61，： | 1 |
| 9 | Rapid accumula- tion of γ-aminobutyric acid and alanine in soybean leaves in re- sponse to an abrupt transfer to lower temperature, darkness, or mechanical manipulation显示文摘 | Wallace W Jacob Secor Larry E Schrader | 1984 | Plant Physiol1984，75，1： | 1 |
| 10 | Cyclooxygenase - 2 is over - ex- pressed in Her - 2/neu - positive breast cancer - evidence for in- volvement of AP - 1 and PEA3 显示文摘 | Kotha S Larry N Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 11 | Hard transparent domes and windows from magnesium aluminate spinel显示文摘 | Anthony A DiGiovanni Larry Fehrenbacher Don W Roy | 2005 | Proceedings of SPIE2005，5786，： | 1 |
| 12 | Metabolites toxic to spruce budworm from balsam fir needle endopgytes显示文摘 | LARRY A C JOHN A F NOAMN J W | 1992 | Mycol Res1992，96，4： | 1 |
| 13 | 显示文摘 | Larry L H Jon K W | 1990 | Chemical Reviews1990，90，： | 1 |
| 14 | Optimization of high molecular weight pullulan production by Aureobasidium pullulans in batch fermentations显示文摘 | Larry H Gibson Robert W Coughlin | 2002 | Biotechnol Prog2002，18，3： | 1 |
| 15 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis W Larry O Patricia B | 1999 | Ecological Economics1999，29，： | 1 |
| 16 | Cancer vaccines: moving toward prevention 显示文摘 | Larry W kwak H | 2011 | Cancer Prev Res2011，4，： | 1 |
| 17 | Ten Elements of Natural Design显示文摘 | Larry W | 1996 | American Nurserymanmagazine1996，1，1： | 1 |
| 18 | A new approach to shale management in field-scale models显示文摘 | Helge H H Larry W L | 1984 | Society of Pe- troleum Engineers Journal1984，24，4： | 1 |
| 19 | Evaluation of the antitumor activity of gemcitabine 显示文摘 | LARRY W H GEORGE B B STAN J | 1990 | Cancer Res1990，50，14： | 1 |
| 20 | Circular Dichroism Spectroscopy Using Coherent Laser-Induced Thermal Gratings 显示文摘 | David W Neyer Larry A Rahn David W Chandler | 1997 | American Chemical Society1997，119，： | 1 |
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