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	题名	作者	年代	出处	被引量
1	Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability.	Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli	2008	World Journal of Gastroenterology2008，14，46：	8
2	Quercetin inhibition of tumor invasion via suppressing PKC Int J显示文摘	Ranelletti FO Ricci R Larocca LM	1992	Cancer1992，50，3：	1
3	Current treatment strategies with lenalidomide in multiple myeloma and future perspectives 显示文摘	Larocca A Cavallo F Mina R	2012	Future Oncol2012，8，10：	1
4	Current treatment strategies with lenalidomide in multiple mye-loma and future perspectives 显示文摘	Larocca A Cavallo F blina R	2012	Future Oncol2012，8，10：	1
5	Current treatment strategies with lenalidomide in multiple myeloma and future perspectives 显示文摘	Larocca A Cavallo F Mina R	2012	Future Oncol2012，8，10：	1
6	Effects of mixing protocol on the performance of nanocomposites based on polyamide 6/acrylonitrile-butadiene-styrene blends显示文摘	OLIVEIRA A D LAROCCA N M PAUL D R	2012	Polym Eng Sci2012，52，2：	1
7	Treatment of brain tumors 显示文摘	ASHBY L LAROCCA R RYKEN T	2005	N Engl J Med2005，352，22：	1
8	Loss of interferon regulatory factor 3 in cells infected with classieal swine fever virus involves the N - terminal protease, Npro显示文摘	LAROCCA S A HERBERT R J CROOKE H	2005	J Virol2005，79，11：	1
9	A Mr 46, 000 human milk fat globule protein that is highly expressed in human breast tumors contains factor Ⅷ like domains显示文摘	Larocca D Peterson JA Urrea R	1991	Cancer Res1991，51，18：	1
10	Sup- pository administration of chemotherapeutic drugs with concomitant radiation for rectal cancer 显示文摘	POKORNY R M WRIGHTSON A LAROCCA R	1997	Dis Lolon Rectum1997，40，12：	1
11	Current treatment strategies with lenalidomide in multiple myeloma and fu- ture perspectives显示文摘	Larocca A Cavallo F Mina R	2012	Future Oncol2012，8，10：	1
12	Treatment of brain tumors显示文摘	Ashby L LaRocca R Ryken T	2005	N Engl J Med2005，352，22：	1
13	Loss of interferon regulatory factor 3 in cells infected with classical swine fever ms involves the N terminal protease, Npro 显示文摘	LaRocca S A Herbert R J Crooke H	2005	J Virol2005，79，：	1
14	Growth - inhibitory effect of quercetin and presence of type - II estrogenbinding sites in human colon - cancer cell lines and primary colorec- tal tumors 显示文摘	Ranelletti FO Ricci R Larocca L M	1992	Int J Cancer1992，50，：	1
15	Characteristic of cell-lines established from human gastric carcinomas显示文摘	Park J G Frucht H Larocca R V	1990	Cancer Res1990，50，：	1
16	An autocrine loopbetween TGF-β1 and the transcription factor brachyury controlsthe transition of human carcinoma cells into a mesenchymalphenotype显示文摘	Larocca C Cohen J R Fernando R I ei al	2013	Mol Cancer Ther2013，12，9：	1
17	telomerase activity in intracranial tumors: prognostic potential for malignant gliomas and meningiomas 显示文摘	Pallini R Larocca LM	1999	Clin Pathol1999，52，：	1
18	Allogeneic apop- totic thymocyte-stimulated dendritic cells expand functional reg- ulatory T cells显示文摘	Da Costa TB Sardinha LR Larocca R	2011	Immunology2011，133，1：	1
19	Telomerase in brain tumors显示文摘	Falchetti M L Larocca L M Pallini R	2002	Childs Nerv Syst2002，18，：	1
20	Structures Oscillations Monitoring with Global Positioning System and Adaptive Filtering Techniques 显示文摘	LAROCCA A P C SCHAAL R E DA FONSECA JR E S	2010	Structural Survey2010，28，3：	1

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