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| 1 | Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms显示文摘OBJECTIVE: To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction(ZYJHNXD) plus dehydroepiandrosterone(DHEA) and menopausalhormone therapy(MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of Yin deficiency with hyperactive fire.METHODS: Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD,femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months.Common questionnaire-based measure instruments included modified Kupperman index(MKI),Hamilton Rating Scale for Anxiety(HAMA), and Hamilton Rating Scale for Depression(HAMD). Follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), 5-hydroxyindole-3-acetic acid(5-HIAA), norepinephrine(NE), dopamine(DA),bone mineral density(BMD), and sleep quality were evaluated before and three months after the treatments.RESULTS: In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly(P < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation(P < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.CONCLUSION: ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis,and improving sleep quality for postmenopausal women. | Lin Jing Zhu Jun Tian Fubo Chen Lanting Zhang Yang Wang Yan Wang Mingyan Hans-Jurgen Gober Li Da-jin Wang Ling | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 6 |
| 2 | Overfertilization in the economically developed and ecologically critical Lake Tai region, China显示文摘 | Yang X Y Fang S B Lant C L 2012 | 2012 | Human Ecology2012，40，： | 1 |
| 3 | Polymer Waveguide Coupled Surface Plasmon Refractive Index Sensor:A Theoretical Study显示文摘A waveguide coupled surface plasmon sensor for detection of liquid with high refractive index(RI)is designed based on polymer materials.The effects of variation of the thickness of the Au film,polymethyl methacrylate(PMMA)buffer,and waveguide layer on the sensing performance of the waveguide are comprehensively investigated by using the finite difference method.Numerical simulations show that a thinner gold film gives rise to a more sensitive structure,while the variation of the thickness of the PMMA buffer and waveguide layer has a little effect on the sensitivity.For liquid with high RI,the sensitivity of the sensor increases significantly.When RI of liquid to be measured increases from 1.45 to 1.52,the sensitivity is as high as 4518.14 nm/RIU,and a high figure of merit of 114.07 is obtained.The waveguide coupled surface plasmon RI sensor shows potential applications in the fields of environment,industry,and agriculture sensing with the merits of compact size,low cost,and high integration density. | Lanting JI Shuqing YANG Rongna SHI Yujie FU Juan SU Chi WU | 2020 | Photonic Sensors2020，10，4： | 1 |
| 4 | Feasible strategies for studying the involvement of DNA methylation and histone acetylation in the stress-induced formation of quality-related metabolites in tea(Camellia sinensis)显示文摘Tea plants are subjected to multiple stresses during growth,development,and postharvest processing,which affects levels of secondary metabolites in leaves and influences tea functional properties and quality.Most studies on secondary metabolism in tea have focused on gene,protein,and metabolite levels,whereas upstream regulatory mechanisms remain unclear.In this review,we exemplify DNA methylation and histone acetylation,summarize the important regulatory effects that epigenetic modifications have on plant secondary metabolism,and discuss feasible research strategies to elucidate the underlying specific epigenetic mechanisms of secondary metabolism regulation in tea.This information will help researchers investigate the epigenetic regulation of secondary metabolism in tea,providing key epigenetic data that can be used for future tea genetic breeding. | Jie Yang Dachuan Gu Shuhua Wu Xiaochen Zhou Jiaming Chen Yinyin Liao Lanting Zeng Ziyin Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 5 | High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector显示文摘High-throughput powder X-ray diffraction(XRD)with white X-ray beam and an energy-dispersive detector array is demonstrated in this work on a CeO;powder sample on a bending magnet synchrotron beamline at the Shanghai Synchrotron Radiation Facility(SSRF),using a simulated energy-dispersive array detector consisting of a spatially scanning silicon-drift detector(SDD).Careful analysis and corrections are applied to account for various experimental hardware-related and diffraction angle-related factors.The resulting diffraction patterns show that the relative strength between different diffraction peaks from energy-dispersive XRD(EDXRD)spectra is consistent with that from angle-resolved XRD(ARXRD),which is necessary for analyzing crystal structures for unknown samples.The X-ray fluorescence(XRF)signal is collected simultaneously.XRF counts from all pixels are integrated directly by energy,while the diffraction spectra are integrated by d-spacing,resulting in a much improved peak strength and signal-to-noise(S/N)ratio for the array detector.In comparison with ARXRD,the diffraction signal generated by a white X-ray beam over monochromic light under the experimental conditions is about 104 times higher.The full width at half maximum(FWHM)of the peaks in q-space is found to be dependent on the energy resolution of the detector,the angle span of the detector,and the diffraction angle.It is possible for EDXRD to achieve the same or even smaller FWHM as ARXRD under the energy resolution of the current detector if the experimental parameters are properly chosen. | Xiaoping Wang Weiwei Dong Peng Zhang Haoqi Tang Lanting Zhang Tieying Yang Peng Liu Hong Wang X.-D.Xiang | 2022 | Engineering2022，8，3： | 0 |
| 6 | Effect of the biosynthesis of the volatile compound phenylacetaldehyde on chloroplast modifications in tea (Camellia sinensis) plants显示文摘Plant volatile compounds have important physiological and ecological functions.Phenylacetaldehyde(PAld),a volatile phenylpropanoid/benzenoid,accumulates in the leaves of tea(Camellia sinensis)plants grown under continuous shading.This study was conducted to determine whether PAld production is correlated with light and to elucidate the physiological functions of PAld in tea plants.Specifically,the upstream mechanism modulating PAld biosynthesis in tea plants under different light conditions as well as the effects of PAld on chloroplast/chlorophyll were investigated.The biosynthesis of PAld was inhibited under light,whereas it was induced in darkness.The structural gene encoding aromatic amino acid aminotransferase 1(CsAAAT1)was expressed at a high level in darkness,consistent with its importance for PAld accumulation.Additionally,the results of a transcriptional activation assay and an electrophoretic mobility shift assay indicated CsAAAT1 expression was slightly activated by phytochrome-interacting factor 3-2(CsPIF3-2),which is a light-responsive transcription factor.Furthermore,PAld might promote the excitation of chlorophyll in dark-treated chloroplasts and mediate electron energy transfer in cells.However,the accumulated PAld can degrade chloroplasts and chlorophyll,with potentially detrimental effects on photosynthesis.Moreover,PAld biosynthesis is inhibited in tea leaves by red and blue light,thereby decreasing the adverse effects of PAld on chloroplasts during daytime.In conclusion,the regulated biosynthesis of PAld in tea plants under light and in darkness leads to chloroplast modifications.The results of this study have expanded our understanding of the biosynthesis and functions of volatile phenylpropanoids/benzenoids in tea leaves. | Lanting Zeng Xiaochen Zhou Xiumin Fu Yilong Hu Dachuan Gu Xingliang Hou Fang Dong Ziyin Yang | 2023 | Horticulture Research2023，10，3： | 0 |
| 7 | PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts显示文摘The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (http://gffzz63bc6e6362d14768swn0qkobp5owu6uqf.ffgz.tsg.suse.edu.cn/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity. | Xinran Dong Yulan Lu Lanting Guo Chuan Li Qi Ni Bingbing Wu Huijun Wang Lin Yang Songyang Wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 8 | Refractive Index Sensor Based on Metal-Clad Planar Polymer Waveguide Operating at 850nm显示文摘A metal-clad planar polymer waveguide refractive index sensor based on epoxy(EPO)polymer materials by using light intensity interrogation at 850 nm is designed.The polymethyl methacrylate(PMMA)material is deployed as the low refractive index(RI)buffer layer in order to better couple the optical guided mode and the surface plasmon polaritons(SPP)mode for working in water environment.The effects of the gold film thickness,PMMA buffer layer thickness,waveguide layer thickness,waveguide width,and gold length on the sensor sensing characteristics have been comprehensively studied.Simulation results demonstrate that the normalized transmission increases quasi-linearly with the increment of RI of the analyte from 1.33 to 1.46.The sensitivity is 491.5 dB/RIU,corresponding to a high RI resolution of 2.6×10^(9)RIU.The designed SPP-based optical waveguide sensor is low-cost,wide-range,and high-precision,and has a broad application prospect in biochemical sensing with merits of miniaturization,flexibility,and multiplexing. | Lanting JI Wei WEI Gang LI Shuqing YANG Yujie FU Juan SU Chi WU | 2021 | Photonic Sensors2021，11，4： | 0 |
| 9 | Accuracy and reliability of orthogonal polynomials in representing corneal topography显示文摘Fitting of corneal topography data to analytical surfaces has been necessary in many clinical and experimental applications,yet absolute superiority of fitting methods was still unclear,and their overfitting risks were not well studied.This study aimed to evaluate the accuracy and reliability of orthogonal polynomials as fitting routines to represent corneal topography.Four orthogonal polynomials,namely,Zernike polynomials(ZPs),pseudo-Zernike polynomials(PZPs),Gaussian-Hermite polynomials(GHPs)and Orthogonal Fourier-Mellin polynomials(OFMPs),were employed to fit anterior and posterior corneal topographies collected from 200 healthy and 174 keratoconic eyes using Pentacam topographer.The fitting performance of these polynomials were compared,and the potential overfitting risks were assessed through a prediction exercise.The results showed that,except for low orders,the fitting performance differed little among polynomials with orders10 regarding surface reconstruction(RMSEs~0.3μm).Anterior surfaces of normal corneas were fitted more efficiently,followed by those of keratoconic corneas,then posterior corneal surfaces.The results,however,revealed an alarming fact that all polynomials tended to overfit the data beyond certain orders.GHPs,closely followed by ZPs,were the most robust in predicting unmeasured surface locations;while PZPs and especially OFMPs overfitted the surfaces drastically.Order 10 appeared to be optimum for corneal surfaces with 10-mm diameter,ensuring accurate reconstruction and avoiding overfitting.The optimum order however varied with topography diameters and data resolutions.The study concluded that continuing to use ZPs as fitting routine for most topography maps,or using GHPs instead,remains a good choice.Choosing polynomial orders close to the topography diameters(millimeters)is generally suggested to ensure both reconstruction accuracy and prediction reliability and avoid overfitting for both normal and complex(e.g.,keratoconic)corneal surfaces. | Junjie Wang Xuefei Li Zheng Wang Pinakin G.Davey Yiyu Li Lanting Yang Mao Lin Xiaobo Zheng Fangjun Bao Ahmed Elsheikh | 2022 | Medicine in Novel Technology and Devices2022，，3： | 0 |
| 10 | Role of histone deacetylase CsHDA8 in regulating the accumulation of indole during the oolong tea manufacturing process显示文摘Aroma is an important quality-related trait of oolong tea.The compounds contributing to oolong tea aromas are mainly produced in response to stress during the enzyme-active stage of the tea manufacturing process.Epigenetic regulation affects stress-induced secondary metabolite production;however,the mechanisms regulating oolong tea aroma compound formation are unclear.In this study,the effect of histone acetylation on indole formation,an important aroma of oolong tea,was revealed and CsHDA8 was identified as a candidate regulator.Additionally,CsHDA8,which was localized in the nucleus and cytoplasm,may function as a histone deacetylase.Moreover,the binding of CsHDA8 to CsTSB2 promoter related to indole decreased during a wounding treatment,which resulted in increased histone acetylation and gene expression.The study results may clarify the regulatory effects of histone acetylation on the formation of tea secondary metabolites,with potential implications for studies on the epigenetic regulation in other non-model horticulture plants. | Xiaochen Zhou Jie Yang Guotai Jian Lanting Zeng Dachuan Gu Xinguo Su Ziyin Yang | 2022 | Beverage Plant Research2022，2，1： | 0 |
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