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| 1 | Vitamin D and autoimmune thyroid diseases显示文摘The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus.Vitamin D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive genes.While VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting results.We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls.Serum vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/ml.Antithyroid antibodies,thyroid functions and demographic parameters were evaluated in all patients.The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation. | Shaye Kivity Nancy Agmon-Levin Michael Zisappl Yinon Shapira Endre V Nagy Katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld | 2011 | Cellular & Molecular Immunology2011，8，3： | 47 |
| 2 | High incidence of malignancies in patients with dermatomyositis and polymyositis:an 11-year analysis显示文摘 | Maoz CR Langevitz P Livneh A | 1998 | Seminars in Arthritis and Rheumatism1998，27，5： | 1 |
| 3 | Attacks of periearditis as a manifestation of familial Mediterranean fever ( FMF ) 显示文摘 | Kees S Langevitz P Zemer D | 1997 | QJM1997，90，10： | 1 |
| 4 | Synovial VLA 1^+ T cells display an oligoclonal and partly distinct repertoire in rheumatoid and psoriatic arthritis显示文摘 | Goldstein I Simon A J Ben Horin S Matzri S Koltakov A Langevitz P | 2008 | Clin Immunol2008，128，： | 1 |
| 5 | Methotrexate selectively modulates TH1/TH2 balance in active meumatoid arthritis patients显示文摘 | Herman S Zurgil N Langevitz P | | 0，，02： | 1 |
| 6 | High incidence of malignancies in patients with dermatomyositis and polymyositis: an 11 year analysis 显示文摘 | Maoz CR Langevitz P Livneh A | 1998 | Semin Arthritis Rheum1998，27，5： | 1 |
| 7 | Anti-cardiolipin antibodies and endothelial function in patients with coronary artery disease 显示文摘 | Marai I Sheehter M Langevitz P | 2008 | Am J Cardiol2008，101，8： | 1 |
| 8 | Methotrexate selectively modulates TH1/TH2 balance in active rheumatoid arthritis patients 显示文摘 | Herman S Zurgil N Langevitz P | 2008 | Clin Exp Rheumatol2008，26，2： | 1 |
| 9 | Anti-cardiolipin antibodies and endothelial function in patients with coronary artery disease显示文摘 | Marai I Shechter M Langevitz P | 2008 | Am J Cardiol2008，101，8： | 1 |
| 10 | Anti-cardiolipin Antibodies and endothelial function in Patients with coronary artery disease显示文摘 | Marai I Shechter M Langevitz P | 2008 | Am J Cardiol2008，101，8： | 1 |
| 11 | Pregnancy issues in scleroderma显示文摘 | Lidar M Langevitz P | 2012 | Autoimmun Rev2012，11，67： | 1 |
| 12 | Skin score decrease in systemic sclerosis patients treated with intravenous immunoglobulin-a preliminary report 显示文摘 | Levy Y Sherer Y Langevitz P | 2000 | Clin Rheumatol2000，19，： | 1 |
| 13 | Low-molecular-weight heparin during pregnancy and delivery:preliminary experience with 41 pregnancies显示文摘 | Dulitzki M Pauzner R Langevitz P | 1996 | Obstet Gynecal1996，87，3： | 1 |
| 14 | Methotrexate selectivelymodulates Thl/Th2 balance in active rheumatoid arthritis patients显示文摘 | Herman S Zurqil N Langevitz P | 2008 | Clin Exp Rheumatol2008，26，2： | 1 |
| 15 | Quality of life in systemic lupus erythematosus: a controlled study显示文摘 | Abu-shakra M Mader R Langevitz P | 1999 | J Rheumatol1999，26，2： | 1 |
| 16 | Low-molecular-weight heparin during pregnancy and delivery:preliminary experience with 41 pregnancies显示文摘 | Dulitzki M Pauzner R Langevitz P | 1996 | Obstet Gynecol1996，87，3： | 1 |
| 17 | Skin Score decrease in systemic sclerosis patients treated with intravenous immunoglobulin - apreliminary report 显示文摘 | Levy Y sherer Y Langevitz P | 2000 | Clin Rheumatol2000，19，： | 1 |
| 18 | Transverse Myelitis in Patients with Antiphospholipid Antibodies – The Importance of Early Diagnosis and Treatment显示文摘 | Y. Sherer S. Hassin Y. Shoenfeld Y. Levy A. Livneh A. Ohry P. Langevitz | 2002 | Clinical Rheumatology2002，，3： | 1 |
| 19 | Fibromyalgia inhuman immunodeficiency virus infection 显示文摘 | Buskila D Gladman DD Langevitz P | 1990 | J Rheumatol1990，17，9： | 1 |
| 20 | Cyelospofine therapy for acquired faetorⅧ inhibitor in a patient with systemic lupus erythematosus 显示文摘 | Sehulman S Langevitz P Livneh A | 1996 | Thromh Haemost1996，76，3： | 1 |
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