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| 1 | Satisfaction with patient-doctor relationships in inflammatory bowel diseases:Examining patient-initiated change of specialist显示文摘AIM:To assess the reasons for,and factors associated with,patient-initiated changes in treating specialist in inflammatory bowel diseases(IBD).METHODS:Prospectively identified IBD patients(n = 256) with ≥ 1 encounter at a metropolitan hospital were surveyed,including whether they had changed treating specialist and why.Negative reasons included loss of confidence,disagreement,and/or personality clash with the specialist.RESULTS:Of 162 respondents,70(43%) had ever changed specialists;30/70(43%) for negative reasons,52/70(74%) in the preceding year.Patients with negative reasons for changing(n = 30) were younger(median,35.2 years vs 45.3 years),had higher IBD knowledge(median,5.0 years vs 4.0 years),yet had lower medication adherence and satisfaction scores(median,19.0 years vs 22.0 years,14.0 years vs 16.0 years respectively,Mann-Whitney tests,all P < 0.05),compared to all other responders(n = 132).Patients with a recent change(for any reason) were more likely to have Crohn's disease,currently active disease,previous bowel resection and recent hospitalization [OR 2.6,95% CI(1.3-5.4),2.2(1.0-4.7),5.56(1.92-16.67),2.0(1.3-3.0),eachP < 0.05].CONCLUSION:Changing specialist appears associated with patient-related(age,nonadherence) and contemporaneous disease-related factors(recent relapse) which,where modifiable,may enhance patient-doctor relationships and therefore quality of care. | Daniel R van Langenberg Jane M Andrews | 2012 | World Journal of Gastroenterology2012，18，18： | 5 |
| 2 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 3 | mi Ranalyzer:a micro RNA detection and analysis tool for next-generation sequencing experiments显示文摘 | Hackenberg M Sturm M Langenberger D | 2009 | Nucleic Acids Research2009，37，： | 1 |
| 4 | New method for retrospective detection of exposure to organophsphorus anticholinesterase: application to alleged sarin victims of Japanese terrorists显示文摘 | Langenberg JP Benschop H | 1997 | Toxicol Appl Pharmacol1997，146，1： | 1 |
| 5 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 6 | Effective-ness of acupuncture as adjunctive therapy in osteoar-thritis of the knee:a randomized,controlled trial显示文摘 | Berman B M Lao L Langenberg P | 2004 | Ann Intern Med2004，141，12： | 1 |
| 7 | Urinary biomarkers in septic acute kidney injury 显示文摘 | Bagshaw S Langenberg C Haase M | 2007 | Intensive Care Med2007，33，7： | 1 |
| 8 | Renal blood flow and function during recovery from experimental显示文摘 | Langenberg C Wan L Egi M | 2007 | Intensive Care Med2007，33，9： | 1 |
| 9 | Risk factorsfor hospital-acquired incontinence in elderly female hip fracturepatients显示文摘 | Palmer M H?Baumgarten M Langenberg P | 2002 | J Gerontol A Biol Sci Med Sci2002，57，10： | 1 |
| 10 | Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized controlled trial显示文摘 | Brian M Lixing Lao Patricia Langenberg | 2004 | Ann Intern Med2004，141，12： | 1 |
| 11 | Risk factors for hospital-acquired incontinence in elderly female hip fracture patients显示文摘 | Palmer M H Baumgarten M Langenberg P | 2002 | J Gerontol A Biol Sci Med Sci2002，57，10： | 1 |
| 12 | Urinary biomarkers in septic acute kidney injury显示文摘 | Bagshaw SM Langenberg C Haase M | 2007 | Intensive Care Med2007，33，7： | 1 |
| 13 | Evaluation ofcommon genetic variants identified by GWAS for early onset and morbid obesity in population-based samples 显示文摘 | den Hoed M Luan J Langenberg C | 2013 | Int J Obes(Lond)2013，37，： | 1 |
| 14 | Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria显示文摘 | VERRECK F A DE BOER T LANGENBERG D M | 2004 | Proc Natl Acad Sci U S A2004，101，13： | 1 |
| 15 | Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria显示文摘 | Frank A W Verreck Tjitske de Boer Dennis M L Langenberg | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，13： | 1 |
| 16 | Chromo- somal anomalies in oligodendroghal tumors are correlated with cllni- cal features 显示文摘 | Van Den Bent M J Looijenga LH Langenberg K | 2003 | Cancer2003，97，5： | 1 |
| 17 | Autocorrelation analysis of bone structure显示文摘 | Rotter M Berg A Langenberger H | 2001 | J Magn Reson Imaging2001，14，1： | 1 |
| 18 | Renal blood flow in experimen- tal septic acute renal failure显示文摘 | Langenberg C Wan L Egi M | 2006 | Kidney Int2006，69，11： | 1 |
| 19 | Tropisetron for postoperative nausesa and vomiting inpatienta after gynecological surgery显示文摘 | Zomers P J Langenberg C J de Bruijn K M | 1993 | Br J Anesthesia1993，1，5： | 1 |
| 20 | Late re- lease of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients显示文摘 | Roodhart J M Langenberg M H Vermaat J S | 2010 | Neoplasia2010，12，1： | 1 |
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