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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | microRNAs: Fad or future of liver disease显示文摘microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. | Ashley M Lakner Herbert L Bonkovsky Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 13 |
| 3 | No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples显示文摘瞄准:当前的工作的目标细胞毒素的 T 淋巴细胞抗原是分析 +49A/G 的流行变体的在有 Crohn 的匈牙利病人的 4 基因(CTLA4 )?ˉs 疾病(CD ) 和 ulcerative (UC ) 。方法:有 CD 的 130 个无关的题目的一个总数并且 150 与 UC,和 170 匹配的控制是为单个核苷酸多型性(SNP ) 的 genotyped。遗传型被使用 PCR/RFLP 测试决定。结果:G 等位基因频率和 GG 遗传型的流行在 CD 组,是 38.1% 和 12.3%40.6% 和 18.6% 在 UC 病人,并且 37.4% 和 15.9% 在控制组分别地。结论:当前的学习的结果显示出 +49G SNP 的那辆马车在异质接合或不在匈牙利人口为 CD 或为 UC 在同型结合的形式授与风险任何一个。 | Lili Magyari Bernadett Faragó Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 4 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 5 | Portfolio optimization with downside constraints显示文摘 | Lakner P Nygren L M | 2006 | Mathematical Finance2006，16，2： | 1 |
| 6 | Optimal control of a mean-reverting inventory显示文摘 | Cadenillas A Lakner P Pinedo M | 2010 | Operations Research2010，58，6： | 1 |
| 7 | Optimal control of a mean-reverting inventory显示文摘 | CADENILIAS A LAKNER P PINEDO M | 2010 | Operations Research2010，58，6： | 1 |
| 8 | Response to com- ments on ' ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models' 显示文摘 | Landreth G E Cramer P E Lakner M M | 2013 | Science2013，340，6135： | 1 |
| 9 | Modeling and Simulation of Generator Circuit Breaker Performance显示文摘 | Fritz O Lakner M | 2006 | Modelica2006，，： | 1 |
| 10 | Interethnic differences of CYP2C9 alleles in healthy Hungarian and Roma population samples: relationship to worldwide allelic frequencies显示文摘 | Sipeky C Lakner L Szabo M | 2009 | Blood Cells Mol Dis2009，43，3： | 1 |
| 11 | Inhibitory effects of microRNA 19bin hepatic stellate cell-mediated fibrogenesis显示文摘 | LAKNER A M STEUERWALD N M WALLINGT L | 2012 | Hepatology2012，56，： | 1 |
| 12 | 显示文摘 | Chen M Donzel L Lakner M | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 13 | Portfolio Optimization with Downside Constraints 显示文摘 | LAKNER P NYGREN L M | 2006 | Mathematical Finance2006，16，2： | 1 |
| 14 | Symbolic dynamics in investigation of quaternionic Julia sets 显示文摘 | M Lakner M Skapin - Rugdj P Petek | 2005 | Chaos Solitons and Fractals2005，24，5： | 1 |
| 15 | The finite differences method for solving systems on irregular shapes显示文摘 | LAKNER M PLAZL I | 2008 | Computers and Chemical Engineering2008，32，12： | 1 |
| 16 | A Procedure Ontology for Advanced Diagnosis of Process Sys- tems显示文摘 | Nemeth E Hangos K M Lakner R | 2010 | Journal of Intelligent & Fuzzy Systems2010，21，： | 1 |
| 17 | Fault Current Limiter Con- cepts Test Results, Si mulations, Applications显示文摘 | Paul W Chen M Lakner M Based on High Temperature S | 2001 | Physiea C2001，354，： | 1 |
| 18 | Portfolio optimization with downside constraints显示文摘 | Lakner P and Nygren L M | 2006 | Mathematical Fincance2006，16，2： | 1 |
| 19 | Superconducting Fault Current Limiter Applications, Technical and Economical Benefits, Simulations and Test Results 显示文摘 | Paul W Chen M Lakner M | 2000 | Cigre2000，，： | 1 |
| 20 | Fault Current Limiter base -d on High Temperature Superconductors - different Concepts Test Results, Simulations, Applications显示文摘 | Paul W Chen M Lakner M | 2001 | Physica C2001，354，： | 1 |
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