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| 1 | Effects and mechanisms of silibinin on human hepatoma cell lines显示文摘瞄准:在肝细胞上调查在试管内效果和 silibinin 的机制癌(HCC ) 细胞生长。方法:人的 HCC 房间线与 silibinin 的不同剂量被对待。HCC 房间生长和增长上的 silibinin 的效果, apoptosis,房间周期前进,嘘一乙酰化作用,和另外的相关信号 transductions 系统地被检验。结果:我们证明 silibinin 显著地减少了 HuH7, HepG2, Hep3B,和 PLC/PRF/5 人的生长肝细胞瘤细胞。减少 Silibinin 的 HuH7 房间生长与显著地起来调整的 p21/CDK4 和 p27/CDK4 建筑群被联系,下面调整的 Rb-phosphorylation 和 E2F1/DP1 建筑群。Silibinin 支持了与下面调整的 survivin 和起来调整的激活的 caspase-3 和 -9 被联系的 HuH7 房间的 apoptosis。Silibinin 的 anti-angiogenic 效果被下面调整的 metalloproteinase-2 (MMP2 ) 和 CD34 显示。我们发现 HuH7 细胞的减少 silibinin 的生长与磷酸酶的增加的活动被联系,十在染色体十上在相当或相同的事物删除了(PTEN ) 并且减少的 p-Akt 生产,在调停 silibinin 的 anti-HCC 显示 PTEN/PI3K/Akt 小径的角色完成。我们也证明 silibinin 增加了乙酰化作用嘘一 H3 和 H4 (AC-H3 和 AC-H4 ) ,显示一个可能的角色改变嘘在减少 silibinin 的 HCC 房间增长的一乙酰化作用。结论:我们的结果定义 silibinin 的在试管内 anti-HCC 效果和可能的机制,并且提供了一个基本原理进一步为 HCC chemoprevention 测试 silibinin。 | John J Lah | 2007 | World Journal of Gastroenterology2007，13，40： | 12 |
| 2 | Diagnosis of turberculosis based on the two specific antigens ESAT-6 and CFP10显示文摘 | van Pinxteren LAH Ravn P Agger EM | 2000 | Clin Diagn Lab Immunol2000，7，2： | 1 |
| 3 | The dynamic pattern of end -tidal carbon dioxide during cardiopulmonary resuscitation: difference be- tween asphyxial cardiac arrest and ventricular fibrillation/pulse- less ventricular tachycardia cardiac arrest 显示文摘 | Lah K Kri-mari- M Grmec S | 2011 | Crit Care2011，15，1： | 1 |
| 4 | 查看详情显示文摘 | Suk J.M Naidu V.R Liu X Lah M.S Jeong K.S | | 0，，： | 1 |
| 5 | Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert- butyl hydroperoxide ( t -BOOH) in HepG2 human hepatoma cells显示文摘 | Janja Plazar Bojana ?egura Tamara T. Lah Metka Filipi? | 2007 | MutRes-Genetic Toxicology and Environmental Mutagenesis2007，，1： | 1 |
| 6 | Cysteine proteina- ses and inhibitors in inflammation: their role in periodon- tal disease显示文摘 | Lah TT Babnik J Schiffmann E | 1993 | J Periodontol1993，64，14： | 1 |
| 7 | Mild cognitive impairment in Parkinson’s disease:subtypes and motor characteristics显示文摘 | Sollinger AB Goldstein FC Lah JJ | 2010 | Parkinsonism Relat Disord2010，16，3： | 1 |
| 8 | 2-Aminothiazole and 2 aminothiazolinone derivatives 显示文摘 | TOPLAK R LAH N VOLMAJER J | 2003 | Acta Crystallogra Sect C2003，59，9： | 1 |
| 9 | Mild cognitive impairment:an opportunity to identify patients at high risk for progression to Alzheimer's disease显示文摘 | Levey A Lah J Goldstein F | 2006 | Clin Ther2006，28，4： | 1 |
| 10 | The role of reactive oxygen species in microcystin-LR-induced DNA damage显示文摘 | Zegura B Lah TT Filipic M | 2004 | Toxicology2004，200，： | 1 |
| 11 | Economic analysis of photovohaic-powered solar domestic hot water systems in Kuwait 显示文摘 | GHONEIM A A AL-HASAN A Y A H ABDUL- LAH | 2002 | Renewable Energy2002，25，： | 1 |
| 12 | Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells 显示文摘 | Vegura B Lah TT Filipic M | 2006 | Mutation Research2006，611，： | 1 |
| 13 | Difference in end-tidal CO2 between asphyxia cardiac arrest and ventricular fibrillation/pulse-less ventricular tachycardia cardiac arrest in the prehospital setting显示文摘 | Grmec S Lah K Tusek-Bunc K | 2003 | Crit Care2003，7，6： | 1 |
| 14 | Different sensitivities of human colon edenocarcinoma(Caco-2), aslroeytoma(IPDDC-A2) and lymphoblastoid(NCNC) cell lines to Mierocystin-LR induced reactive oxygen species and DNA damage显示文摘 | ZEGURA B VOLCIC M LAH T | 2009 | Toxicon2009，52，3： | 1 |
| 15 | Determination of folates in foods by high-performance liquid chromatography with fluorescence detection after precolumn conversion to 5-methyltetrahydrofolates显示文摘 | S Ndaw M Bergaentzlé D Aoudé-Werner S Lahély C Hasselmann | 2001 | Journal of Chromatography A2001，，1： | 1 |
| 16 | Patterns of microeystin - LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis显示文摘 | Zegura B Zajc I Lah TT | 2008 | Toxicon2008，51，4： | 1 |
| 17 | Proteases in brain tumor progression显示文摘 | Levicar N Nutall R K Lah T T | 2003 | Acta Neurochir2003，145，： | 1 |
| 18 | Impact of Splenectomy for Lymph Node Dissection on Long-Term Surgical Outcome in Gastric Cancer显示文摘 | Kang Young Lee MD Sung Hoon Noh MD Woo Jin Hyung MD Jun Ho Lee MD Ki Hyeok Lah MD Seung Ho Choi MD Jin Sik Min MD PhD | 2001 | Annals of Surgical Oncology2001，，5： | 1 |
| 19 | The dynamic pattern of endtidal carbon dioxide during cardiopulmonary resuscitation:difference between asphyxial cardiac arrest and ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest显示文摘 | Lah K Krizmaric M Grmec S | 2011 | Crit Care2011，15，1： | 1 |
| 20 | Adrenomedullin: a vasoactive and natriuretic piptide with therapeutic potential 显示文摘 | Frishman WH | 2000 | Heart Dis2000，2，3： | 1 |
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