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| 1 | Analysis of Cytosine Methylation Pattern in Response to Water Deficit in Pea Root Tips显示文摘 | Labra M Ghiani A Citterio S Sgorbati S Sala F Vannini C RuffiniCastigllone M Braoale M | 2002 | Plant Biol2002，4，： | 1 |
| 2 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，7： | 1 |
| 3 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，7： | 1 |
| 4 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip 显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，： | 1 |
| 5 | Analysis of cytosine methylation pat tern in response to water deficit in pea root tips显示文摘 | Labra M Ghiani A Citterio S Sgorbati S Sala F Tannini C Ruffini-Castiglione M Bracale M | 2002 | Plant Biol2002，4，： | 1 |
| 6 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，： | 1 |
| 7 | Genomic Changes in Transgenic Rice (Oryza sativa L) Plants Produced by Infecting Calli with Agrobacterium Tumefaciens 显示文摘 | Labra M Savini C Bracale M | 2001 | Plant Cell Reports2001，20，： | 1 |
| 8 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，： | 1 |
| 9 | Discrete element simulation of rock cutting 显示文摘 | Rojek J Ofiate E Labra C | 2011 | International Journal of Rock Mechanics&Mining Sciences2011，48，6： | 1 |
| 10 | Discrete element simulation of rock cutting显示文摘 | Rojek J Ofiate E Labra C | 2011 | International Journal of Rock Mechanics and Mining Sciences2011，48，6： | 1 |
| 11 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip显示文摘 | M Labra C Vannini F Grassi M | 2004 | Theor Appl Genet2004，109，： | 1 |
| 12 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip 显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，： | 1 |
| 13 | Genomie stability in Arabidopsis thaliana transgenie plants obtained by floral dip显示文摘 | Labra M Vannini C Grassi F | 2004 | Theor Appl Genet2004，109，： | 1 |
| 14 | Analysis of cytosine methylation pattern in response to water deficit in pea root tips 显示文摘 | Labra M Ghiani A Citterio S Sgorbati S Sala F Vannini C Ruffini-castiglione M Bracale M | 2002 | Plant Biol2002，4，6： | 1 |
| 15 | Genomic stability in Arabidopsis thaliana transgenic plants obtained by floral dip 显示文摘 | Labra M Vannini C Grassi F | 2004 | TheorAppl Genet2004，109，7： | 1 |
| 16 | Discrete e显示文摘 | ROJEK J ()MATE E LABRA C | 2011 | International Journal of Rock Mechanics and Mining Sciences2011，48，6： | 1 |
| 17 | Discrete element simulation of rock cutting显示文摘 | Rojek J Onate E Labra C | 2011 | International Journal of Rock Mechanics and Mining Sciences2011，48，： | 1 |
| 18 | 大麻抑制β淀粉样多肽导致的星形胶质细胞半通道激活:一种神经元保护机制显示文摘阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放。本课题组的既往研究显示,激活的小胶质细胞或炎症介质可导致星形胶质细胞上缝隙连接43半通道开放;而外源性或内源性大麻均可以减少这种开放。但尚不清楚大麻是否可以减少由Aβ激活星形胶质细胞半通道导致的神经元死亡。本研究培养星形胶质细胞及海马脑片,分别单用Aβ处理或用Aβ及大麻(WIN,2-AG,或甲酰胺基)联合处理。采用单通道膜片钳及延时乙啡啶摄取法记录胶质细胞半通道的活动,采用Fluoro-Jade C染色检测神经元死亡。结果显示,大麻完全抑制了由Aβ导致的星形胶质细胞半通道的活性及炎症反应。而且,大麻完全抑制了由Aβ导致的星形胶质细胞缝隙连接43半通道开放而引起的兴奋毒性谷氨酸及ATP的释放,大麻也可以很大程度上减少由Aβ导致的海马脑片神经元的损伤。通过调节星形胶质细胞的功能来保护神经元是目前治疗AD的新策略,本研究结果为此提供了新思路。 | Gajardo-Gómez R Labra VC Maturana CJ Shoji KF Santiba?ez CA Sáez JC Giaume C Orellana JA 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，1： | 0 |
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