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| 1 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Curcumin as a possi- ble lead compound against hormone-independent multidrug-resistant breast cancer显示文摘 | Labbozzetta M Notarbartolo M Poma P | 2009 | Ann N Y Acad Sci2009，1155，： | 1 |
| 3 | Analysis of possiblemechanisms accounting for raf-1 kinase inhibitor protein downregula-tion in hepatocellular carcinoma显示文摘 | Poma P Labbozzetta M Vivona N | 2012 | OMICS2012，16，11： | 1 |
| 4 | Analysis of possible mechanisms accounting for Raf - 1 kinase inhibitor protein downregulation in hepatocellular carcinoma 显示文摘 | Poma P Labbozzetta M Vivona N | 2012 | OMICS - A Journal of Integrative Biology2012，16，11： | 1 |
| 5 | Analysis of possible mechanisms accounting for Raf-1 kinase inhibitor protein downregulationinhepatocellularcarcinoma 显示文摘 | Poma P Labbozzetta M Vivona N | 2012 | OMICS2012，16，11： | 1 |
| 6 | Induction of apoptosis by the proteasome inhibitor MGI32 in human HCC cells:Porssible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-calenin-mediated transactivation显示文摘 | Cervello M Giannitrapani L La Rosa M Notarbartolo M Labbozzetta M Poma P | 2004 | Int J Mol Med2004，13，74： | 1 |
| 7 | Influence of CYP3A5 and ABCBI gene polymorpbisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients 显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2011 | lnt J Mol Med2011，28，6： | 1 |
| 8 | Analysis of possible mechanisms accounting for raf-1 kinase inhibi- tor protein downregulation in hepatocellular carcinoma 显示文摘 | Poma P Labbozzetta M Vivona N | 2012 | OMICS2012，16，11： | 1 |
| 9 | Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2011 | Int J Mol Med2011，28，6： | 1 |
| 10 | The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2009 | Ann Transplant2009，14，1： | 1 |
| 11 | In- fluence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2011 | Int J Mol Med2011，28，6： | 1 |
| 12 | Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin;implications for their antitumor and chemosensitizing activities 显示文摘 | Labbozzetta M Baruchello R Marchetti P | 2009 | Chem Biol Interact2009，181，1： | 1 |
| 13 | Antitumor effects of the novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production 显示文摘 | Poma P Notarbartolo M Labbozzetta M ct al | 2006 | Int J Oncol2006，28，4： | 1 |
| 14 | Unusual high dose of tacrolimus in liver transplant patient, a case report显示文摘 | Alessio Provenzani Monica Notarbartolo Manuela Labbozzetta Paola Poma Adele D’Antoni Piera Polidori Giovanni Vizzini Natale D’Alessandro | 2012 | International Journal of Clinical Pharmacy2012，，2： | 1 |
| 15 | The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF7 breast cancer cell line: analysis of the possible molecular basis显示文摘 | Poma P Notarbartolo M Labbozzetta M | 2007 | Int J Mol Med2007，2，3： | 1 |
| 16 | Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatoeel- lular carcinoma显示文摘 | Poma P Labbozzetta M Vivona N | 2012 | OMICS2012，16，11： | 1 |
| 17 | The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2009 | Annals of Transplantation2009，，01： | 1 |
| 18 | Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacroli- mus dosing in Caucasian liver and kidney transplant patients显示文摘 | Provenzani A Notarbartolo M Labbozzetta M | 2011 | lnt J Mol Med2011，28，6： | 1 |
| 19 | Curcumin as a possible lead compound against hormone-independent,multidrug-resistant breast cancer显示文摘 | Labbozzetta M Notarbartolo M Poma P | | 0，，： | 1 |
| 20 | The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients显示文摘 | Provenzani A Notarhartolo M Labbozzetta M | 2009 | Ann Transplant2009，14，1： | 1 |
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