|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ribosome Biogenesis Factor Bmsl-like Is Essential for Liver Development in Zebrafish显示文摘Ribosome biogenesis in the nucleolus requires numerous nucleolar proteins and small non-coding RNAs.Among them is ribosome biogenesis factor Bmsl,which is highly conserved from yeast to human.In yeast,Bmsl initiates ribosome biogenesis through recruiting Rcll to pre-ribosomes.However,little is known about the biological function of Bmsl in vertebrates.Here we report that Bmsl plays an essential role in zebrafish liver development.We identified a zebrafish bms1l^(sq163) mutant which carries a T to A mutation in the gene bmsl-like(bms1l).This mutation results in L^(152) to Q^(152) substitution in a GTPase motif in Bmsll.Surprisingly,bmsll^(sq163) mutation confers hypoplasia specifically in the liver,exocrine pancreas and intestine after 3 days post-fertilization(dpf).Consistent with the bmsll^(sq163) mutant phenotypes,whole-mount in situ hybridization(WISH) on wild type embryos showed that bmsll transcripts are abundant in the entire digestive tract and its accessory organs.Immunostaining for phospho-Histone 3(P-H3) and TUNEL assay revealed that impairment of hepatoblast proliferation rather than cell apoptosis is one of the consequences of bms1l^(sq163) giving rise to an under-developed liver.Therefore,our findings demonstrate that Bmsll is necessary for zebrafish liver development. | Yong Wanga,Yue Luoa,Yunhan Hong(b,),Jinrong Peng(a,),Lijan Lo(a,b,) a College of Animal Sciences,Zhejiang University,Hangzhou 310058,China b Department of Biological Sciences,National University of Singapore,Science Drive 4,Singapore 117543,Singapore | 2012 | Journal of Genetics and Genomics2012，39，9： | 4 |
| 2 | 用喷雾法提高哈次木霉1295-22对草坪草病害的生防效果显示文摘哈次木霉(Trichoderma harzianum)1295-22菌株是一种对多种真菌病害具有较好防治效果的生物制剂。研究报道了施用1295-22的颗粒剂和雾剂对匍匐剪股颖的腐霉根腐、褐斑和币斑病的防治效果。研究表明在温室或田间,喷施1295-22的分生孢子悬浮液(SA),都显著减轻了匍匐剪股颖草坪的这3种病害。若在孢子水悬液中添加0.1%的Triton X-100的防治效果更好。若每周都喷洒SA,其防治效果相当于常规杀菌剂。撒施颗粒剂(GA)也能显著减轻根腐病、币斑病和褐斑病的叶部症状,草坪质量也有所提高。用1295-22的SA或GA处理过的剪股颖根区的木霉菌(Trichoderma spp.)群体比未处理的提高了10~100倍,但是仅在喷施SA之后,1295-22才以高水平存在。总之,1295-22在根围和叶围都有较强的竞争力。在使用颗粒剂之后再喷施分生孢子悬浮液可减轻根部和叶部病害。 | Lo C T Nelson E B 朱廷恒 | 1999 | 国外畜牧学(草原与牧草)1999，，2： | 4 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Exponents of nonnegative matrix pairs显示文摘 | Suw Lo S | 2003 | Linear Algebr APPL2003，，263： | 1 |
| 5 | Synthesis of Eu3+-activated yttrium oxysulfide red phosphor by flux fusion method显示文摘 | LO C L DUH J G CHIOU B S PENG C C | 2001 | Chemistry and Physics2001，71，： | 1 |
| 6 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 7 | Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes显示文摘 | Hattenbach LO Falk B Nurnberger F | 2002 | Ophthalmologica2002，216，3： | 1 |
| 8 | Degradable transport network: travel time budget of travelers with heterogeneous risk aversion 显示文摘 | Lo H K Luo X W Siu B W Y | 2006 | Transportation Research Part B2006，40，9： | 1 |
| 9 | Application of dynamical systems theory to trajectory design for a libration point mission显示文摘 | HOWELL K C BRADEN B T LO M W | 1997 | Journal of Astronautical Sciences1997，45，： | 1 |
| 10 | Enzymecatalyzed production and chemical composition of diacylglycerols from corn oil deodorizer distillate 显示文摘 | LO S K BAHARIN B S TAN C P | 2004 | Food Biotechnol2004，18，： | 1 |
| 11 | Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes 显示文摘 | Hattenbach LO Falk B Nurnberger F Koch FH Ohrloff C | 2002 | Ophthalmologica2002，216，3： | 1 |
| 12 | Improved biocontrol efficacy of Trichoderma harzianum 1295- 22 for foliar phases of turf diseases by use of spray applications 显示文摘 | Lo C T Nelson E B Harman G E | 1997 | Plant Dis1997，81，： | 1 |
| 13 | Impact of supplement with Lacto- bacitlus and Bifidobacterium-eontaining yogurt on triple therapy for He- licobacter pylori eradication 显示文摘 | SHEU B S WU J J LO C Y | 2002 | Ailment Pharmacol Ther2002，16，： | 1 |
| 14 | Inetics of ethanol oxidation on electroless Ni-P/SnO2/Ti electrodes in KOH solutions显示文摘 | LO Y L HWANG B J K | 1995 | Electrochem Soc1995，142，2： | 1 |
| 15 | Cytochrome P450 2E1 Expression Induces nepatocyte Resistance to Cell Death from Oxidative Stress显示文摘 | Jones B E Liu H Lo C R | 2002 | hntioxid Redox Signal2002，4，5： | 1 |
| 16 | Correction criteria for the ,suppression of vitrinite reflectance in hydrogen-rich kerogens: preliminary guidelines显示文摘 | Lo H B | 1993 | Organic Geochemistry1993，20，6： | 1 |
| 17 | Drinking and driving in Singapore,1987 to 1989显示文摘 | Chao T C Lo D S T Bloodworth B C | | 0，，03： | 1 |
| 18 | Seizure outcome after resection of cavernous malformations is better when surrounding hemosiderin-stained brain also is removed 显示文摘 | Baumann CR Schuknecht B Lo Russo G | 2006 | Epilepsia2006，47，3： | 1 |
| 19 | Weekly compared with daily blood glucose monitoring in women with diet-treated gestational diabetes显示文摘 | HAWKINSJ S CASEY B M LO J Y | 2009 | Obstet Gynecol2009，113，6： | 1 |
| 20 | Distributed 6D vector antennas design for direction of arrival applications 显示文摘 | L Lo Monte B Elnour D Erricolo | 2007 | IEEE2007，2，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员