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| 1 | Utility of fluorescent cholangiography during laparoscopic cholecystectomy: A systematic review显示文摘AIM: To verify the utility of fluorescent cholangiography for more rigorous identification of the extrahepatic biliary system.METHODS: MEDLINE and Pub Med searches were performed using the key words 'fluorescent cholangiography', 'fluorescent angiography', 'intraoperative fluorescent imaging', and 'laparoscopic cholecystectomy' in order to identify relevant articles published in English, French, German, and Italian during the years of 2009 to 2014. Reference lists from the articles were reviewed to identify additional pertinent articles. For studies published in languages other than those mentioned above, all available information was collected from their English abstracts. Retrieved manuscripts(case reports, reviews, and abstracts) concerning the application of fluorescent cholangiography were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. In contrast to classic meta-analyses, statistical analysis was performed where the outcome was calculated as the percentages of an event(without comparison) in pseudo-cohorts of observed patients.RESULTS: A total of 16 studies were found that involved fluorescent cholangiography during standard laparoscopic cholecystectomies(n = 11), singleincision robotic cholecystectomies(n = 3), multiport robotic cholecystectomy(n = 1), and single-incision laparoscopic cholecystectomy(n = 1). Overall, these preliminary studies indicated that this novel technique was highly sensitive for the detection of important biliary anatomy and could facilitate the prevention of bile duct injuries. The structures effectively identified before dissection of Calot's triangle included the cystic duct(CD), the common hepatic duct(CHD), the common bile duct(CBD), and the CD-CHD junction. A review of the literature revealed that the frequenciesof detection of the extrahepatic biliary system ranged from 71.4% to 100% for the CD, 33.3% to 100% for the CHD, 50% to 100% for the CBD, and 25% to 100% for the CD-CHD junction. However, the frequency of visualization of the CD and the CBD were reduced in patients with a body mass index > 35 kg/m2 relative to those with a body mass index < 35 kg/m2(91.0% and 64.0% vs 92.3% and 71.8%, respectively).CONCLUSION: Fluorescent cholangiography is a safe procedure enabling real-time visualization of bile duct anatomy and may become standard practice to prevent bile duct injury during laparoscopic cholecystectomy. | Antonio Pesce Gaetano Piccolo Gaetano La Greca Stefano Puleo | 2015 | World Journal of Gastroenterology2015，21，25： | 21 |
| 2 | Adjusting CA19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein显示文摘AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9(P = 0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the CA19-9 value by dividing it by serum bilirubin level meant that 21.5% in the BJ and 49% in the MJ group remained with a positive CA19-9 value(P = 0.003),while adjusting the CA19-9 value by dividing it by serum CRP value meant that 31.4% in the BJ group and 76.5% in the MJ group still had a positive CA19-9 value(P = 0.000004).Sensitivity,specificity,positive predictive values of CA19-9 > 32 U/mL were 82.3%,45% and 59.1%;when the cutoff was CA19-9 > 100 U/mL they were,respectively,68.6%,64.7% and 66%.When the CA19-9 value was adjusted by dividing it by the bilirubin or CRP values,these became 49%,78.4%,69.4% and 76.5%,68.6%,70.9%,respectively.CONCLUSION:The present study proposes CRP as a new and useful correction factor to improve the diag-nostic value of the CA19-9 tumor marker in patients with cholestatic jaundice. | Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo Domenico Russello | 2012 | World Journal of Gastroenterology2012，18，31： | 20 |
| 3 | Laparo-endoscopic “Rendezvous” to treat cholecysto-choledocolithiasis: Effective,safe and simplifies the endoscopist’s work显示文摘AIM: To investigate our clinical experience with combined laparo-endoscopic Rendezvous (RV) for the treatment of patients affected by gallstones and common bile duct (CBD) stones and especially to study the never evaluated opinion of the endoscopist concerning the difficulty of the intraoperative endoscopic procedure during the RV in comparison with standard endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: Eighty consecutive patients affected by cholecystolithiasis and diagnosed or suspected CBD stones were treated with a standardized 'tailored' RV. The relevant technical features, the feasibility, the effectiveness in stone clearance, the safety but also the simple evaluation of difficulty and agreement of the endoscopist were analyzed with a questionnaire. RESULTS: The feasibility was 97.5% and the effectiveness 100% concerning CBD clearance and solution of coexisting problems at the papilla. Minor morbidity was 3.3%, the operating time was prolonged by a mean of 14 min, the mean hospital stay was 3.8 d and only one stone’s recurrence occurred. The endoscopist evaluated the procedure to be simpler than standard ERCP-ES in 81.2% of the cases.CONCLUSION: Simultaneous RV carries higheffectiveness and safety at least comparable to those reported for other options. The endoscopist is very often satisfied with this approach because of the minimization of some steps of the endoscopic procedure and avoidance of relevant iatrogenic risk factors. If the mandatory collaboration between surgeons and endoscopists is guaranteed, this approach can often be preferable for the patient, the surgeon, the endoscopist and the hospital. | Gaetano La Greca Francesco Barbagallo Michele Di Blasi Andrea Chisari Rosario Lombardo Rosario Bonaccorso Saverio Latteri Andrea Di Stefano Domenico Russello | 2008 | World Journal of Gastroenterology2008，14，18： | 15 |
| 4 | Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type Ⅱ patients 显示文摘 | Ouvina SM La Greca RD Zanaro NL | 2001 | THromb Res2001，102，2： | 1 |
| 5 | Simultaneous lapa- roendoscopic rendezvous for the treatment of cholecystocho- ledocholithiasis 显示文摘 | I La Greca G Barbagallo F Sofia M | 2009 | Surg Endosc2009，24，4： | 1 |
| 6 | Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type Ⅱ patients 显示文摘 | Ouvina SM La Greca RD Zanaro NL | 2001 | Thromb Res2001，102，2： | 1 |
| 7 | Development of the social anxiety scale for children, Reliability and concurrent validity显示文摘 | La Greca A M | 1988 | l Clin Child Psychol1988，17，： | 1 |
| 8 | New method of extracorporeal concentration of ascetic fluid as a treatment of refractory ascites显示文摘 | Brendolan A La Greca G Fecondini L | 1989 | Int J Artif Organs1989，12，5： | 1 |
| 9 | Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic Ⅱ patients显示文摘 | Ouvina SM La Greca RD Zanaro NL | 2001 | Thromb Res2001，102，： | 1 |
| 10 | Studies on brain density in hemodialysis and peritoneal dialysis 显示文摘 | La Greca G Biasioli S Chiaramonte S | 1982 | Nephron1982，31，2： | 1 |
| 11 | The electrocardiographicmethod for positioning the tip of central venous catheters 显示文摘 | Pittiruti M La Greca A Scoppettuolo G | 2011 | J Vase Access2011，12，4： | 1 |
| 12 | The electrocardiographic method for positioning the tip of central venous catheters显示文摘 | Pittiruti M La Greca A Scoppettuolo G | 2011 | J Vasc Access2011，12，4： | 1 |
| 13 | Perineo-ano-rectal injuries: clinical experi- ence显示文摘 | La Greca G Gagliardo S Sofia M | 2008 | Chit Ital2008，60，1： | 1 |
| 14 | Successful endoscopic repair of an unusual colonic perforation following polypectomy using an endoclip device显示文摘Colonic perforation during endoscopic diagnostic or therapeutic procedures,represents an uncommon occurrence even if,together with haemorrhage,it is still the most common complication of colonoscopy,with an incidence ranging between 0.1% and 2% of all colonoscopic procedures. The ideal treatment in these cases remains elusive as the endoscopist and the surgeon have to make a choice case by case,depending on many factors such as how promptly the rupture is identified,the condition of the patient,the degree of contamination and the evidence of peritoneal irritation. Surgical interventions both laparotomic and laparoscopic,and other medical non-operative solutions are described in the literature. Only three cases have been reported in the literature in which the endoscopic apposition of endoclips was used to repair a colonic perforation during colonoscopy. Ours is the first case that the perforation itself was caused by the improper functioning of a therapeutic device. | Francesco Barbagallo Giorgio Castello Saverio Latteri Emanuele Grasso Salvatrice Gagliardo Gaetano La Greca Michele Di Blasi | 2007 | World Journal of Gastroenterology2007，13，20： | 1 |
| 15 | Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial显示文摘 | Claudio Ronco Rinaldo Bellomo Peter Homel Alessandra Brendolan Maurizio Dan Pasquale Piccinni Gluseppe La Greca | 2000 | The Lancet2000，，9223： | 1 |
| 16 | Post-traumatic inflammatory pseudotumor of the breast with atypical morphological features: A potential diagnostic pitfall. Report of a case and a critical review of the literature显示文摘 | Giada Maria Vecchio Paolo Amico Giuseppe Grasso Enrico Vasquez Gaetano La Greca Gaetano Magro | 2011 | Pathology - Research and Practice2011，，5： | 1 |
| 17 | Development of the social anxiety scale for children: reliability and concurrent validity 显示文摘 | LA GRECA A M DANDES S K WICK P | 1988 | J Clin Child Psychol1988，17，1： | 1 |
| 18 | The electrocardio- graphic method for positioning the tip of central venous catheters 显示文摘 | Pittiruti M La Greca A Scoppettuolo G | 2011 | J Vasc Access2011，12，4： | 1 |
| 19 | Rendezvous technique versus endoscopic retrograde eholangiopancreatography to treat bile duct stones reduces endoscopic time and pancreatic damage显示文摘 | La Greca G Barbagallo F Di Blasi M | 2007 | J Laparoendosc Adv Surg Tech A2007，17，2： | 1 |
| 20 | The Diabetes social support questionnairefamily version:evaluating adolescents'diabetes-specific support from family members显示文摘 | La Greca AM Bearman KJ | 2002 | J Pediatr Psychol2002，27，： | 1 |
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