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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Unsu- pervised BCM projection pursuit algorithms for classification of simulated radar presentation显示文摘 | BACHMANN C M MUSMAN S A LUONG D etal | 1994 | Neural Networks1994，7，4： | 1 |
| 3 | Resource-constrained project scheduling:A survey of recent developments显示文摘 | LONG LUONG DUC OHSATO A | 1998 | Computers&Ops Res1998，25，4： | 1 |
| 4 | Activation of nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state显示文摘 | Zakkar M Van der Heiden K Luong le A | | 0，，11： | 1 |
| 5 | Unsaturated fatty acids down- regulate SREBP isoforms la and lc by two mechanisms in HEK-293 cells显示文摘 | HANNAH V C OU J LUONG A | 2001 | Biological Chemisry2001，276，6： | 1 |
| 6 | Stromelysin-1 and interlukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atheroselerosis显示文摘 | RAURAMAA R VAISANEN S B LUONG L A | 2000 | Arterioscler Thromb Vasc Biol2000，20，： | 1 |
| 7 | Unsupervised BCM projection pursuit algorithms for classification of simulated radar presentation 显示文摘 | Bachmann C M Musman S A Luong D | 1994 | Neural Networks1994，7，4： | 1 |
| 8 | The link between allerg显示文摘 | Luong A Roland PS | 2008 | Otolaryngolo gic Clinics of North America2008，41，： | 1 |
| 9 | The Link Between Allergic Rhinitis and Chronic Otitis Media with Effusion in Atopic Patients显示文摘 | Luong A Roland PS | 2008 | Oto- laryngologic clinics of North America2008，41，： | 1 |
| 10 | Isolation of urokinase by affinity ultrafiltration显示文摘 | Male K Nguyen A Luong J | | 0，，01： | 1 |
| 11 | Synthesis and characterization of a water-soluble affinity polymer for trypsin purification显示文摘 | Luong J H T Male K B Nguyen A L | 1988 | Biotechnology and Bioengineering1988，31，5： | 1 |
| 12 | Electrochemical detectors prepared by electroless deposition for microfabricated electrophoresis chips显示文摘 | Hilmi A Luong JH | 2000 | Anal Chem2000，72，19： | 1 |
| 13 | Insulin-like growth factor Ⅰ controls a mutually exclusive association of RACK1 with protein phosphatase 2A and β1 integrin to promote cell migration 显示文摘 | Kiely P A O'Gorman D Luong K | 2006 | Mol Cell Biol2006，26，11： | 1 |
| 14 | Unsu-pervised BCM projection pursuit algorithms for classification ofsimulated radar presentations 显示文摘 | BACHMANN C M MUSMAN S A LUONG D | 1994 | Neural Networks1994，7，4： | 1 |
| 15 | Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase显示文摘 | Luong T N Rothman S C | 2002 | Protein Sci2002，，11： | 1 |
| 16 | The role of fungi in chronic rhinosinusitis显示文摘 | LUONG A MARPLE B | 2005 | Otolaryngol Clin North Am2005，38，： | 1 |
| 17 | Unsupervised BCM projection pursuit algorithms for classification of simulated radar presentation 显示文摘 | Bachmann C M Musman S A Luong D | 1994 | Neural Networks1994，7，4： | 1 |
| 18 | Seeking common pathophysiology in asthma, atopy and sinusitis显示文摘 | Porter PC Ongeri V Luong A | 2011 | Trends Immunol2011，32，2： | 1 |
| 19 | Use methanesulfonic acid as catalyst for the production linear alkylbenzenes显示文摘 | Luong B X Petre A L Hoelderich W F | 2004 | J Catal2004，226，： | 1 |
| 20 | Role of nuclear factor kappab in cardiovascular health and disease显示文摘 | Van der Heiden K Cuhlmann S Luong le A | 2010 | Clin Sci (Lond)2010，118，10： | 1 |
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