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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 3 | Structural evolution of Eucalyptus tar pitch-based carbons during carbonization显示文摘 | MARCOS J P VANYA M D NELCY D S CHOYU O SATIKA O LUIZ C P | 2005 | Biomass Bioenergy2005，28，1： | 1 |
| 4 | The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicarta reveals novel active site features 显示文摘 | Artur T C Paul A M Luiz F D | 2004 | Eur J Biochem2004，271，： | 1 |
| 5 | Stable episomal expression system under control of a stress inducible promoter enhances the immunogenicity of Bacillus subtilis as a vector for antigen delivery显示文摘 | Paccez J D Luiz W B Sbrogio-Almeida M E | | 0，，： | 1 |
| 6 | Principal components analysis applied to performance and carcass traits in the chicken显示文摘 | Luís Fernando Batista P Irineu Umberto P Cláudio Manoel Rodrigues D M M^onica Corrêa L Luiz Lehmann C | 2006 | Anim Res2006，55，： | 1 |
| 7 | Depositional and diage- netic controls on the reservoir quality of lower cretaceous pen- dencia sandstones, Potiguar Rift Basin, Brazil显示文摘 | Sylvia M C Luiz F D Rog6rio S | 2000 | AAPG Bul- letin2000，84，11： | 1 |
| 8 | Standardization of a duplex RT-PCR for the detection of influenza A and Newcastle disease viruses in migratory birds显示文摘 | Paula B M S Cristlane D Luiz S | 2005 | J Vir- ol Methods2005，123，2： | 1 |
| 9 | Esterification of oleic acid with ethanol by 12-tungstophosphoric acidsupported on zirconia显示文摘 | CLAUDINEI F 0 LUIZ M D FILLIPE A C | 2010 | Appl Catal:A2010，372，11： | 1 |
| 10 | Acute hepatic failure in a patient with hyperthyroidism and virus B hepatitis:recovery after plasmapheresis and thyroidectomy-a case report显示文摘 | Débora VS Luiz TN Márcia CB | 2008 | Arq Bras Endocrinol Metab2008，52，3： | 1 |
| 11 | Multielass analysis of antibiotic residues in honey by ultra-performance liquid chromatography tandem mass spectrometry 显示文摘 | VIDAL J L M LUIZ M D M A GONZALEZ R R | 2009 | J Agric Food Chem2009，57，： | 1 |
| 12 | Biogenic gas production from major Amazon reservoirs, Brazil 显示文摘 | Luiz P R Marco A D S Bohdan M | 2003 | Hydrological Processes2003，17，7： | 1 |
| 13 | Ecophysiological traits of plant functional groups in forest and pasture ecosystems from eastern Amazonia, Brazil 显示文摘 | Tomas F D Luiz A M James R E | 2007 | Plant Geology2007，193，1： | 1 |
| 14 | Effect of the gray cast iron mi- crostructure on milling tool life and cutting force 显示文摘 | LUIZ R M D ANSELMO E D | 2013 | Journal of the Brazilian Society of Mechanical Sciences and Engineering2013，35，1： | 1 |
| 15 | Synthesis of a boronmodified phenolic resin显示文摘 | Aparecida M K Luiz C P Milton F D | 2010 | J Aerosp Techn Manag2010，2，2： | 1 |
| 16 | Standardization of a duplex RT-PCR for the detection of influenza A and Newcastle disease viruses in migratory birds显示文摘 | Paula B M S Cristiane D Luiz S | | 0，，02： | 1 |
| 17 | Standardization of a duplex RT-PCR for the detection of influenza A and Newcastle disease viruses in migratory birds显示文摘 | Paula B M S Cristiane D Luiz S | 2005 | J Virol Methods2005，123，2： | 1 |
| 18 | Biogenic gas production from major Amazon reservoirs,Brazil显示文摘 | Luiz P R Marco A D Bohdan M | 2003 | Hydrological Processes2003，17，7： | 1 |
| 19 | Electrochemical Ozone Production:Influence of the Supporting Electrolyte on Kinetics and Current Efficiency 显示文摘 | Leonardo M D S Luiz A D F Julien F C B | 2003 | Electrochim Acta2003，48，6： | 1 |
| 20 | Denosine kinase deficiency in associated with developmental abnormalities and reduced transmethylation显示文摘 | Barbara A M Yvonne Y S Mike S A Jamie D S,Luiz A P,Margarita I T,Peter S S,Elizabeth A W,Luke M M,Conrad W A | | 0，，： | 1 |
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