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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Modelling the photo-oxidation of hydrocarbons in seawater:Effect of salinity显示文摘 | LUIZ M GARCIA N A | 1994 | Sci Mar1994，58，3： | 1 |
| 5 | Modelling the pho- to-oxidation of hydrocarbons in seawater: Effect of salinity显示文摘 | GUTIERREZ M I LUIZ M GARCIA N A | 1994 | Sci Mar1994，58，3： | 1 |
| 6 | Reliability worth applied to transmission expansion planning based on ant colony system 显示文摘 | ARMANDO M LEANDRO S LUIZ A | 2010 | Electrical Power and Energy Sys- tems2010，32，10： | 1 |
| 7 | Esterification of oleic acid with ethanol by 12- tungstophosphoric acid supported on zirconia显示文摘 | Claudinei F Olivcira Luiz M Dezaneti Fillipe A C Garci- a | 2010 | Applied Catalysis A : General2010，372，2： | 1 |
| 8 | Efficient Genetic Transformation System for the Ochratoxigenic Fungus Aspergillus carbonarius显示文摘 | Luiz Rodrigo I. Morioka Márcia C. Furlaneto Andréa C. Bogas Patrícia Pompermayer Rubens T. D. Duarte Maria Lúcia C. Vieira Maria Angélica Ehara Watanabe Maria Helena P. Fungaro | 2006 | Current Microbiology2006，，6： | 1 |
| 9 | Effects of tempera- ture on events in the infection cycle of two clonal lineages of Phy- tophthora in显示文摘 | Josh Marcelo N M Luiz A M Fxtuardo S G M | 2009 | Plant Disease2009，93，5： | 1 |
| 10 | Methods for yeast characterization from industrial products 显示文摘 | LUIZ H G KEILA M R Duarte J L A etal | 2000 | Food Microbiol2000，17，： | 1 |
| 11 | Friedel-Crafts reactions anisole with acetic anhydride over HPW/SiO2显示文摘 | Luiz A M Cardoso Walter Alves Jr | 2004 | J Mol Catal A2004，209，12： | 1 |
| 12 | Electrochemical impedance spectroscopy study during acceler- ated life test of conductive oxides: Yi (Ru+Yi+Ce)0:-system 显示文摘 | Leonardo M Da Silva Karla C Femandes Luiz A De Faria et a l | 2004 | Electrochemica Acta2004，49，27： | 1 |
| 13 | The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicarta reveals novel active site features 显示文摘 | Artur T C Paul A M Luiz F D | 2004 | Eur J Biochem2004，271，： | 1 |
| 14 | Principal components analysis applied to performance and carcass traits in the chicken显示文摘 | Luís Fernando Batista P Irineu Umberto P Cláudio Manoel Rodrigues D M M^onica Corrêa L Luiz Lehmann C | 2006 | Anim Res2006，55，： | 1 |
| 15 | Anew route to obtain PVDF/PANI conducting blends显示文摘 | Luiz F M Giovana de A L Simonedo C L | 2006 | Eur Polyrn J2006，42，11： | 1 |
| 16 | Investigation of surface properties of Ru-based oxide electrodes containing Ti, Ce and Nb 显示文摘 | Mario H P Santana Leonardo M Da Silva Luiz A De Faria | 2003 | Electrochimica Acta2003，48，： | 1 |
| 17 | Mechanism of anticlasogenicity of Agaricus blazei murill mushroom organic extracts in wild type CHO(K1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays显示文摘 | Jordao B Q da Eira A F Ribeiro L R Mantovani M S | 2003 | Mutation Research2003，528，1： | 1 |
| 18 | Solving Replica Placement and Request Distribution in Content Distribution Networks显示文摘 | Tiago Arafijo Nevesa Lacia M A Drummonda Luiz S | 2010 | Electronic Notes in Discrete Mathematics2010，36，1： | 1 |
| 19 | Is visual scanning better than mental practice in hemispatial neglect? Re- suits from a pilot study 显示文摘 | FERREIRA H P LEITE LOPES M A LUIZ R R | 2011 | Top Stroke Rehabil2011，18，2： | 1 |
| 20 | an asynchronous parallel metaheuristic for the period vehicle routing problem显示文摘 | Lucia M A Drummond Luiz S Oehi Dalessandro S Vianna | 2001 | Future Generation Computer Systems2001，17，4： | 1 |
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