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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Determination of As, Sb, Se, Te and Bi in milk by slurry sampling hydride atomic fluorescence spectrometry 显示文摘 | Patricia C M Luisa C Agustin P | 2004 | Talanta2004，62，1： | 1 |
| 3 | Production and release of yessotoxins by the dinoflagellates Protoceratium reticulatum and Lingulodinium polyedrum in culture显示文摘 | Beatriz P Pilar Riobo'a M Luisa Ferna'ndezb | 2004 | Toxicon2004，44，： | 1 |
| 4 | Disturbance process and dynam ics in coastal dunes显示文摘 | Hesp P A Luisa Martinez M | 2007 | Plant Disturbance Ecology2007，，7： | 1 |
| 5 | Novel pH -sensi- tive non - ionic surfaetant vesicles : Comparison between Tween 21 and Tween 20 显示文摘 | LUISA D M CARLOTTA M MARIADEA P | 2011 | Colloids and Surfaces B : Biointerfaccs2011，82，1： | 1 |
| 6 | Identification and quan- tification of flavonol glycosides in cultivated blueberry cultivars 显示文摘 | Urska V Domenico M Luisa P | 2011 | Journal of Food Composition and Analysis2011，21，41： | 1 |
| 7 | Nutritional factors affecting the production of two bacteriocins from lactic acid bacteria on whey显示文摘 | NELSON P GUERRA M LUISA R | 2001 | Int J Food Micbiol2001，70，： | 1 |
| 8 | Evidence that low doses of taxol enhance the functional transactivatory properties of p53 on p21 war promoter in MCF-7 breast cancer cells显示文摘 | Luisa P M Francesca G Fabrizia M | 2006 | Federation of European Biochemical Socie- ties2006，580，9： | 1 |
| 9 | Effect of ripening stage of grapes on the low molecular weight phenolic compounds of red wines 显示文摘 | Silvia P Luisa M | 2005 | European Food Research Technology2005，220，： | 1 |
| 10 | Concentration dependence of 13 C-NMR spectra of triglycerides:implications for the NMR analysis of olive oils显示文摘 | Luisa M Claudio L Maurizio P | | 0，，： | 1 |
| 11 | An overview on silica aerogels synthesis and different mechanical reinforcing strategies显示文摘 | Hajar M Luisa D Antonio P | 2014 | Journal of Non-Crystalline Solids2014，385，2： | 1 |
| 12 | Long-term effects of a maintenance program after supervised or self-monitored training programs in patients with COPD显示文摘 | Puent~Maestu L Luisa Sdnz M Sdnz P etal | 2003 | Lung2003，181，2： | 1 |
| 13 | Divergent roles for C-type lectins expressed by cells of the innate immune system 显示文摘 | EAMON P MCGREAL LUISA M P | 2004 | Molecular Immunology2004，41，11： | 1 |
| 14 | 显示文摘 | Luisa P Nevesb L A Afonsoe C A M | 2009 | Desalination2009，245，13： | 1 |
| 15 | Facilitated transport of CO2 and SO2 through Supported Ionic Liquid Membranes (SILMs)显示文摘 | Luisa P Nevesb L A Afonsoc C A M | 2009 | Desalination2009，245，13： | 1 |
| 16 | Synthesis of polyhy-droxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding显示文摘 | Lemos P C Luisa S S Maria A M R | 2006 | J Biotechnol2006，122，： | 1 |
| 17 | Influence of Temperature and of Structure of Antimony Substrate on Gallium Diffusion into the GaSh Semiconductor Compeund显示文摘 | Valentin M K Luisa P B | 2000 | Journal of Alloys and Compounds2000，313，： | 1 |
| 18 | Effects of dietary lipid level on growth and lipid utilization by juvenile Atlantic halibut(Hippoglossus hippoglossus L)显示文摘 | Martins D A Luisa M P Santosh P L | 2007 | Aquaculiure2007，263，： | 1 |
| 19 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by'reconditioning PCR'显示文摘 | JANELLE R T LUISA A M MARTIN F P | 2002 | Nucleic Acids Research2002，30，9： | 1 |
| 20 | Heteroduplexes inmixed-template amplifications: formation, consequence andelimination by ‘reconditioning PCR’ 显示文摘 | Janelle R T Luisa A M Martin F P | 2002 | Nucleic Acid Research2002，30，9： | 1 |
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