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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA显示文摘 | Gao ZL Li DG Lu HM Gu XH | 1999 | World Journal of Gastroenterology1999，5，5： | 13 |
| 3 | 基于原发肿瘤表观扩散系数直方图分析预测高级别浆液性卵巢癌患者铂类药物化疗敏感性显示文摘高级别浆液性卵巢癌(HGSOC)是最常见和最致命的卵巢癌组织学亚型,初始肿瘤细胞减灭术后进行一线铂类药物化疗是其标准的治疗方法,但其治疗后复发率高达75%。运用间隔6个月有无复发这一非常简单有效的方法对铂敏感及铂耐药患者进行分类,并能为后续的个体化治疗方案选择提供客观依据。弥散加权成像(DWI)可以利用表观扩散系数(ADC)检测细胞和细胞膜的完整性,以量化水分子在组织中的扩散程度,而基于ADC分析的直方图则可分析肿瘤的生物异质性。该研究通过治疗前阶段HGSOC原发病变全肿瘤区域和全实性肿瘤区域ADC直方图分析,对患者铂类药物的化疗反应予以预测。 | Lu J Li HM Cai SQ 毛咪咪(编译) | 2022 | 中华医学杂志2022，102，3： | 5 |
| 4 | A Whitecap Coverage Model Based on the Surface Slope For Criterion of Wave Breaking显示文摘Using the limit surface slope as a criterion of wave breaking,a simple model for estimatingthe spatial fraction of breaking surface of sea at an instant,which is regarded as the whitecap coverge inthis paper,is analytically derived from the probability density of surface slope based on Gaussianstatistics.The resulting fraction is found depending on the fourth moment of wave spectum,m4,as well asthe critical threshold of surface slope.By expressing the fourth moment in terms of the Neumannspectrum,a formula linking the fraction and wind speed for fully developed sea states is obtianed.Anotherformula relating the fraction to both wind speed and fetch(or duration)is achieved by expressing m4 interms of the Krylov spectrum and applying the empirical relationships used in the SMB ocean wave pre-dicting technique.A comparison between these results and the field data of whitecap coverage collected byMonahan and O'Muircheartuigh shows an encouraging agreement. | Xu, DL Yu, DY Lu, HM | 1998 | China Ocean Engineering1998，13，1： | 4 |
| 5 | Experimental study of gold distribution in the algae-organic matter-fluid system显示文摘THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are | Xie, SC Yin, HF Wang, HM Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL | 1997 | Chinese Science Bulletin1997，42，19： | 3 |
| 6 | Clinical evalualien of a rapid im- munhromatograpphic assay based on the 38 kD antigen of Mycubacterium tuberculosis on patients with pulmonary tubercu- losis in China显示文摘 | CDE RA LU HM SHI YZ | 1996 | Tubercle and Lung Disease1996，77，： | 1 |
| 7 | Clinical evaluation of a rapid immunochromatograpphic assay based on the 38 kDa antigen of Mycobacterium tuberculosis on patients with pulmonary tuberculosis in China显示文摘 | Lu HM Shi YZ | 1996 | Tubercle and Lung Disease1996，77，： | 1 |
| 8 | Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling显示文摘 | Lu YC Chen Y J Wang HM | 2012 | Cancer Prev Res: Phila2012，5，4： | 1 |
| 9 | The mechanism of kinetic ; inhibition of Cuinduced oxidation of low density lipoprotein by lanthanide ions 显示文摘 | Liu HM Cheng Y Lu JF | 2006 | Journal of Inorganic Biochemistry2006，100，7： | 1 |
| 10 | TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD 显示文摘 | Tao HM Chen GZ Lu XD | 2011 | Can J Neural Sci2011，38，6： | 1 |
| 11 | Up-regulation of tripartite motifcontaining 29 promotes cancer cell proliferation and predicts poor survival in colorectal cancer显示文摘 | Jiang T Tang HM Lu S | 2013 | Med Oncol2013，30，4： | 1 |
| 12 | Microbiotas and environments of the Nansha Islands and adjacent sea显示文摘IN the past 12 years, the Multidisciplinary Oceanographic Expedition Team to Nansha Islandsorganized by the Chinese Academy of Sciences has carried out many investigations and ob-tained a lot of scientific research results. In the present study, 177 surface sediments and 7core specimens were used for analyzing foraminifers, ostracods, radiolarians, bryozoans, gas-tropods, bivalves, diatoms, dinonagellates, sporopollen and calcareous nannoplankton, con- | Chen, MH Cai, HM Tu, X Lu, LH | 1997 | Chinese Science Bulletin1997，42，20： | 1 |
| 13 | Culture Issues in using the SF-36 health survey in asia:results from taiwan显示文摘 | Tseng HM Lu JF Gandek B | 2003 | Health Qual Life Outcomes2003，261，1： | 1 |
| 14 | Enoxaparin and heparin comparison of deep vein thrombosis prophylaxis in total hip replacement patients显示文摘 | Senaran H Acaro?lu E Ozdemir HM | | 0，，01： | 1 |
| 15 | Effects of tetrandrine and chlorpromazine on synthesis of collagen and hyaluronic acid in cultured human lung fibroblasts显示文摘 | Liu HL Lu HM Li DG | 1995 | Acta Pharmacologica Sinica1995，16，： | 1 |
| 16 | The expression of AT1 receptor on hepatic stellate cells in rat fibrosis inducedby CC14显示文摘 | Wei HS Lu HM Li DG | 2001 | Chin Med J2001，114，6： | 1 |
| 17 | Targeting p53 as atherapeu- tic strategyin sensitizing TRAIL-induced apoptosis in carl- cer cells显示文摘 | Zhao J Lu Y Shen HM | 2012 | Cancer Lett2012，314，1： | 1 |
| 18 | Role of ISF-FDG PET/CT in detec- ting pelvic lymph-node metastases in patients with early-stage uter- ine cervical cancer: comparison with MRI findings显示文摘 | Lv K Guo HM Lu YJ | 2014 | Nucl Med Commun2014，35，12： | 1 |
| 19 | Commissioning a passive-scattering proton therapy nozzle for accurate SOBP delivery 显示文摘 | Engelsman M Lu HM Herrup D | 2009 | Med Phys2009，36，6： | 1 |
| 20 | Seroepidemiologic survey for hepatitis B virus infection in Taiwan : the effect of hepatitis B mass immunization 显示文摘 | Hsu HM Lu CF Lee SC | 1999 | J Infect Dis1999，179，2： | 1 |
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