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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 3 | A MUCLTI-PARAMETER SPLITTING EXTRAPOLATION AND A PARALLEL ALGORITHM显示文摘The finite element solutions of elliptic equations are shown to have a multiparameter asymptotic error expansion. Based on this expansion and a multi-parametersplitting extrapolation technique, a parallel algorithm for solving multi-dimensional equations with high order accuracy is introduced. | ZHOU Aihui(Institute of Systems Science, Academia Sinica, Beijing 100080, China)Liem Chin-ho Shih Tsi-min(Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong)LU Tao(Institute of Chengdu Computer Application, Academia Sinica, Ch | 1997 | Systems Science and Mathematical Sciences1997，10，3： | 8 |
| 4 | Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B显示文摘EfectofQinlinggranuleintreatmentof102patientswithchronichepatitisBHUANGZhengMing1,YANGXinBo1,CAOWenBin1,ZHOUYiJun2andLULi... | HUANG Zheng Ming 1, YANG Xin Bo 1, CAO Wen Bin 1, ZHOU Yi Jun 2 and LU Li Yan 2 1Department of Pharmacology, Chinese PLA Beijing Medical School, Beijing 100071, China 2Chinese PLA 184 Hospital, Yingtan 350000, Jiangxi Province, Ch | 1998 | World Journal of Gastroenterology1998，4，1： | 7 |
| 5 | At the crossroad of conception and infection: initiatives for immunoglobulin-based contraceptive R & D显示文摘Better understanding of the immunological inechanisms implying the insemination and the infertility of some menand women is needed and crucial to the developnlent of an effective imlntmocona'aceptive method. To provide goodprotection against conception or infection, and avoid any possible and unexpected complications which immunocontra-cepfive 'vaccine' my arise of, it seems the right time for scientists to create a virtually new thinking for this extremelyurgent and important issue. This conceptual article describes our original thoughts of the future development of im-munocontracepdves, preferably, based on immunoglobulins rather than vaccines, against human sperm specific antigensand seminal plasma immtmosuppressive factors. Its general correctness, advantages and feasibility for fertility regula-tion and prevention of infection are discussed. | Nian-Qing LU Yi-Fei WANG Yu-Feng HUANG Xing-Hai WANG Jiangsu Family Planning Research Institute, Nanjing 210029, China Department of Reproductive Health and Research, WHO, 20 Avenue Appia, CH 1211 Geneva, Switzerland Nanjing General Hospital, Nanjing 210002, China | 1999 | Asian Journal of Andrology1999，1，3： | 2 |
| 6 | Sexual knowledge, attitudes and activity of older people in Taipei, Taiwa 显示文摘 | Wang TF Lu CH Chen IJ | 2008 | Journal of Clinical Nursing2008，17，： | 1 |
| 7 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 8 | Water-soluble constituents from Calliccrpa pedun- culata显示文摘 | Lu CH Shen YM | 2008 | Chin J Nat Med2008，6，3： | 1 |
| 9 | Initially unrecognized dementia in a young man wihe neurosyphilis 显示文摘 | Lee CH Lin wc Lu CH | 2009 | Neurolodist2009，15，： | 1 |
| 10 | The role of hepatitis B surface antigen quantification in predicting HBsAg loss and HBV relapse after discontinuation of lamivudine treatment 显示文摘 | Chen CH Lu SN Hung CH | 2014 | J Hepatol2014，61，3： | 1 |
| 11 | Clinical characteristics and therapeutie outcomes of nosocomial super-infection in adult bacte- rial meningitis显示文摘 | Huang CR Chen SF Lu CH | 2011 | BMC Infect Dis2011，11，： | 1 |
| 12 | Versatility of the pedicled peroneal artery perforator flaps for soft-tissue coverage of tle lower leg and foot defects?显示文摘 | Lu TC Lin CH Lin CH | 2011 | Plast Reconstr Aesthet Surg2011，64，3： | 1 |
| 13 | Improved chondrogenesis and engineered cartilage formation from TGF-β3-expressing adipose-derived stem cells cultured in the rotating-shaft bioreactor显示文摘 | Lu CH Lin KJ Chiu HY | | 0，，： | 1 |
| 14 | Motion Estimation Algorithm Using Interblock Correlation显示文摘 | HSIEH CH LU PC SHYN JS | 1990 | Electronics Letters1990，26，5： | 1 |
| 15 | Risk factors of subsequent vertebral compression fractures after vertebroplasty显示文摘 | Lu K Liang CL Hsieh CH | 2012 | Pain Med2012，3，： | 1 |
| 16 | 17beta- Estradiol inhibits mesenchymal stem cells-induced human AGS gastric cancer cell mobility via suppression of CCLS- Src/Cas/Paxillin signaling pathway显示文摘 | Kuo CH Liu CJ Lu CY | 2014 | Int J Med Sci2014，11，1： | 1 |
| 17 | L2-RLS based object tracking显示文摘 | XIAO Z Y LU H CH WANG D | 2014 | IEEE Transaction on Circuits and Systems for Video Technology2014，24，8： | 1 |
| 18 | Carotid atherosclerosis, intima media thickness and risk factors-an analysis of 1781 asymptomatic subjects in Taiwan 显示文摘 | Sun Y Lin CH Lu CJ | 2002 | Atherosclerosis2002，164，1： | 1 |
| 19 | The accuracy of video imaging prediction in soft tissue outcome after bimaxillary orthognathic surgery 显示文摘 | Lu CH Ko EW Huang CS | 2003 | J Oral Maxillofac Surg2003，61，3： | 1 |
| 20 | Clozapine for blephamspasm, obsess-ive-compulsive symptoms, and psychotic symptoms in a patient of old brain infarction 显示文摘 | Sun CH Lu CH Huang TL | 2006 | Clin Neuropharmacol2006，29，： | 1 |
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