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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 3 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 4 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 5 | Diterpenoid Alkaloids from Aconitum Pendulum显示文摘A new diterpenoid 12 -epiacetyldehydrolucidusculline (1) and a new norditerpenoid alkaloid 2-hydroxydeoxyaconitine (2) were isolated from the roots of Aconitum pendulum, together with eight known alkaloids aconitine (3), deoxyaconitine (4), 3-acetylaconitine (5), 12-epiacetyldehydronapelline (6), dehydrolucidusculline (7), dehydronapelline (8), 12 -epidehydrnapelline (9), and noeline (10). The structures of the new alkaloids (1-2) were determined on the basis of spectral method. | Zhang, SM Tan, LQ Ou, QY | 1997 | Chinese Chemical Letters1997，8，11： | 5 |
| 6 | Genetic aspects of floral fragrance in plants显示文摘 | Xiang, L Milc, JA Pecchioni, N Chen, LQ | 2007 | 中国生物学文摘2007，21，10： | 4 |
| 7 | An easy model for prediction of human renal clear cell carcinoma:curve fitting for three kidney tumors observed for over 10 years显示文摘 | Yao L Li XS Zhang L He ZS Zhou LQ | 2014 | Chinese Medical Journal2014，，4： | 3 |
| 8 | Grayanane Diterpenoids from Pieris formosa显示文摘Three grayanane diterpenoids 1-3 were isolated from Pierisfonnosa. 1 was identifiedas a new natural product and 2 and 3 as known grayanoside C and grayanotoxin XVIII on the basisof spectral analysis. | Wang, LQ Ding, BY Zhao, WM Qin, GW | 1998 | Chinese Chemical Letters1998，9，5： | 3 |
| 9 | Microgravimetric DNA sensor based on quartz crystal microbalance: comparison of oligonucleotide immobilization methods and the application in genetic diagnosis显示文摘 | Huang LQ Li SF | 2001 | Biosens Bioelectron2001，16，12： | 1 |
| 10 | Suppression of platelet-type 12lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme 显示文摘 | Cheng R Sun LQ | 2001 | Biochem Biophys Res Commun2001，284，4： | 1 |
| 11 | Local bases of primitive non-powerful signed digraphs 显示文摘 | Wang LQ Miao ZK Yan C | 2009 | Discr Math2009，309，： | 1 |
| 12 | Cellular uptake,distribution,and stability of 10-23 deoxyribozymes显示文摘 | Dass CR Saravolac EG Li Y Sun LQ | 2002 | Antisense Nucleic Acid Drug Dev2002，12，5： | 1 |
| 13 | Identification of tissue-specific microRNAs from mouse显示文摘 | Mariana LQ Reinhard R Abdullah Y | 2002 | Curr Biol2002，12，： | 1 |
| 14 | Effect of intravenous immunoglobulin and vitamin C on progression of experimental autoimmune myocarditis in mice显示文摘 | Hu YF Gong FQ Chen LQ | 2008 | Zhejiang Da Xue Xue Bao2008，37，4： | 1 |
| 15 | Development of anterior cingulate functional connectivity from late childhood to early adulthood 显示文摘 | Kelly AM Di Martino A Uddin LQ | 2009 | Cereb Cortex2009，19，： | 1 |
| 16 | The treatment progress of chronic ulcerative colitis 显示文摘 | Wang LQ Ma X | 2008 | Chin Med Frontier2008，3，1： | 1 |
| 17 | Two -step scheme for rapid identi?cation and differentiation of Legionella pneumophila and Non -Le-gionella pneumophila species 显示文摘 | ZhanXY Li LQ Hu CH | 2010 | J Clin Microbiol2010，48，2： | 1 |
| 18 | Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway显示文摘 | Luo XH Guo LJ Yuan LQ | 2005 | Exp Cell Res2005，309，： | 1 |
| 19 | Effect of different depths ofanesthesia on perioperative stress response in children undergoingadenoidectomy and tonsillectomy显示文摘 | Yang LQ Li JJ Chen SQ | 2013 | CNS Neurosci Ther2013，19，2： | 1 |
| 20 | Psoriasis, lymphoma and etanercept : is there a correlation 显示文摘 | Miranda LQ Bressan AL Rehfeldt FV | 2012 | An Bras Dermatol2012，87，1： | 1 |
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