|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Probiotics in poultry:Modes of action Worlds Poult显示文摘 | Jin L Z Ho Y W Abdullah N | 1997 | Sci J1997，53，： | 1 |
| 3 | Identification of tissue-specific microRNAs from mouse显示文摘 | Mariana LQ Reinhard R Abdullah Y | 2002 | Curr Biol2002，12，： | 1 |
| 4 | Elevated Serum Arginase Activity Levels in Patients with Breast Cancer显示文摘 | Muhammet Fevz? Polat Sey?than Tays? Sev?n? Polat Abdullah B?yük Ebubek?r Bakan | 2003 | Surgery Today2003，，9： | 1 |
| 5 | Elec- tromigration noise measurements using a novel AC/DC water -level noise measurement system 显示文摘 | ABDULLAH M Y CHARLES I' CHEN Songming | 1997 | IEEE Transactions on Electron Devices1997，44，1： | 1 |
| 6 | Microbial Colonisation and degradation of some fibrous crop residues in the rumen of goats显示文摘 | Ho Y Abdullah N Jalaludin S | 1996 | Asian Australasian Journal of animal sciences1996，9，： | 1 |
| 7 | Or- gano-montmorillonites as Catalysts for Selective Syn- thesis of Glycerol Monolaurate显示文摘 | WIBOWO T Y ABDULLAH A Z ZAKARIA R | 2010 | Applied Clay Sci- ence2010，50，2： | 1 |
| 8 | Effect of low Fe3+ doping oncharacteristics,sonocatalytic activity and reusability ofTiO2 nanotubes catalysts for removal of rhodamine Bfrom water显示文摘 | Pang Y L Abdullah A Z | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 9 | Necrotizing enterocolitis in 20, 822 infants: analysis of medical and surgical treatments 显示文摘 | Abdullah F Zhang Y Camp M | 2010 | Clin Pediatr2010，49，2： | 1 |
| 10 | Direct Synthesis of Mesoporous 12-tungstophosphoric Acid SBA-15 Cat- alyst for Selective Esterification of Glycerol and Lauric Acid to Monolaurate显示文摘 | HOOP Y ABDULLAH A Z | 2014 | Chemical Engineer- ing Journal2014，250，： | 1 |
| 11 | Comparative study on theprocess behavior and reaction kinetics in sonocatalyticdegradation of organic dyes by powder and nanotubesT1O2显示文摘 | Pang Y L Abdullah A Z | 2012 | Ultrasonics Sonochemistry2012，19，3： | 1 |
| 12 | Splenectomy in hereditary spherocytosis:review of 1,657 patients and application of the pediatric quality indicators显示文摘 | Abdullah F Zhang Y Camp M | 2009 | Pediatr Blood Cancer2009，52，： | 1 |
| 13 | Growth performance,intestinal microbial populations,and serum cholesterol of broilers fed diets containing lactobacillus cultures显示文摘 | Jin L Z Ho Y W Abdullah N | 1998 | Poultry Science1998，77，9： | 1 |
| 14 | Drying performance and thermal transient study with solar radiation supplemented by forced -ventilation 显示文摘 | M O Abdullah F A Mikie C Y Lam | 2006 | Intemational Journal of Thermal Sciences (S1290-0729)2006，10，45： | 1 |
| 15 | Economic analysis of photovoltaic-powered solar domestic hot water systems in Kuwait显示文摘 | Ghoneim A A Al Hasan A Y Abdullah A H | 2002 | Renewable Energy2002，25，： | 1 |
| 16 | Growth performance, intestinal microbial populations, and serum cholesterol of broilers fed diets containing Lactobacillus cultures显示文摘 | Jin L Z Ho Y W Abdullah N | 1998 | Poultry science1998，77，9： | 1 |
| 17 | Time de- pendent breakdown of ultrathin gate oxide显示文摘 | Abdullah M Y Nariman H F Michael M | 1999 | IEEE Trans Electron Dev1999，47，7： | 1 |
| 18 | Placement of wind turbines using genetic algorithms 显示文摘 | Grady S A Hussaini M Y Abdullah M M | 2005 | Renewable Energy2005，30，2： | 1 |
| 19 | Intrathecal vincristine: Long-term survivor of potentially fatal chemotherapy error显示文摘 | Iqbal Y Abdullah MF Tuner C | 2002 | Annals of Saudi Medicine2002，22，12： | 1 |
| 20 | Growth performance, in- testinal microbial populations, and serum cholesterol of broilers fed diets containing LactobaciUus cultures显示文摘 | Jin L Z Ho Y W Abdullah N | 1998 | Pouh Sci1998，77，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员