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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The three Ds of PCR-based genomic analysis of phytobacteria:Diversity,detection,and disease diagnosis显示文摘 | Louws F J Rademaker J K W de Bruijin F J | 1999 | Annual Review of Phytopathology1999，37，： | 2 |
| 3 | The three Ds of PCR-based genomic analysis of phytobacteria:diversity,detection,and disease diagnosis显示文摘 | Louws F J Rademaker J L W de Bruijn F J | 1999 | Annu Rev Phytopathol1999，38，： | 1 |
| 4 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 5 | Spinal stenosis following anterior spinal fusion显示文摘 | LOUW J A DOMMISSEE G F ROOS M F | 1988 | Spine1988，13，8： | 1 |
| 6 | Specific genomic fingerprints of phytopathogenic Xanttzomonas and Pseudomonas pathovars and strains generated with repeti tive sequences and PCR显示文摘 | Louws F J Fulbright D W Stephens C T | 1994 | Applied and Environmental Microbiology1994，60，7： | 1 |
| 7 | The three Dsof PCR - based genomic analysis of phytobacteria :Diversity,detection, and disease diagnosis 显示文摘 | Louws F J Rademaker J L W de Bruijn F J | 1999 | Annual Review ofPhytopathology1999，37，： | 1 |
| 8 | Methyl bromide alternatives for control of black root rot of straw- berry in Georgia 显示文摘 | BRANNEN P M FERGUSON L M LOUWS F J | 2004 | Phytopathology2004，94，6： | 1 |
| 9 | Specific genomic fingerprints of phytopatbogenic Xanthomonas and Pseudopathovars and strains generated with repetitive sequences and PCR显示文摘 | Louws F J Fulbright D W Taylor S C | 1994 | Applied and Environmental Microbiology1994，60，： | 1 |
| 10 | Responses of soil microbial biomass and N availability to transition strategies from conventional to organic farming systems显示文摘 | Tu C Louws F J Creamer N G | 2006 | Agricul- ture Ecosystems & Environment2006，113，1234： | 1 |
| 11 | The three Ds of PCR-based genomic analysis of phytobacteria: diversity, detection, and disease diagnosis 显示文摘 | LOUWS F J RADEMAKER J L W De BRUUN F J | 1999 | Annual Review of Phytopathology1999，37，： | 1 |
| 12 | A compre hensive species to strain taxonomic framework for Xan thomonas显示文摘 | Rademaker J L W Louws F J Schultz M H | 2005 | Phytopathology2005，95，： | 1 |
| 13 | Comparison of AFLP and rep-PCR genomic finger printing with DNA homology studies:Xanthomonas as a model system显示文摘 | Rademarker J L W Hoste B Louws F J | 2000 | Int J Syst Evol Microbiol2000，50，： | 1 |
| 14 | Rep-PCR-mediated genomic fingerprinting:A rapid and effective method to identify Clavibacter michiganensis显示文摘 | LOUWS F J BELL J MEDINA-MORA C M | 1998 | Phytopathology1998，88，8： | 1 |
| 15 | Specific gcnomic fingerprints of hytopathogenic Xanthomonas and Pseudomonas pathovars and strains generated with repetitive sequences and PCR显示文摘 | Louws F J F Stephens D W de Bruijn F J | 1994 | Appl Environ Microbiol1994，60，： | 1 |
| 16 | Specific genomic fingerprints of phytopathogenic Xanthomonas and Pseudomonas pathovars and strains generated with repetitive sequences and PCR显示文摘 | Louws F J Fulbright D W Stephens C T | 1994 | Applied and Environmental Microbiology1994，60，7： | 1 |
| 17 | Specific genomic fingerprints of phytopathogenic Xanthomonas and Pseudamonas pathovars and strains generated with repetitive sequences and PCR显示文摘 | Louws F J Fulbright D W Stephens C T de Bruijn F J | 1994 | Applied and Environmental Microbiology1994，60，： | 1 |
| 18 | Compari- son of AFLP and Rep-PCR genomic fingerprinting with DNA- DNA homology studies= Xanthomonas as a model system 显示文摘 | RADEMAKER J L HOSTE W B LOUWS F J | 2000 | Int J Syst Evol Micr2000，50，： | 1 |
| 19 | Characterization of the diversity of ecologically important microbes by rep-PCR genomic fingerprinting 显示文摘 | RADEMAKER J L W LOUWS F J VERSALOVIC J BRUIJIN F | 2004 | Molecular Microbial Ecology Manual2004，12，： | 1 |
| 20 | Specific genomic fingerprints of phytopathogenic Xanthomonas and Pseudomonas pathovars and strains generated with repetitive sequences and PCR显示文摘 | LOUWS F J FULBRIGHT D W STEPHENS C T DE BRUIJIN FJ | 1994 | Applied and Environmental Microbiology1994，60，7： | 1 |
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