|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 3 | A nationwide survey of diabetes education, self-management and glycemic control in patients with type 2 diabetes in China显示文摘 | GUO Xiao-hui YUAN Li LOU Qing-qing SHEN Li SUN Zi-lin ZHAO Fang DAI Xia HUANG Jin YANG Hui-ying | 2012 | Chinese Medical Journal2012，，23： | 74 |
| 4 | Plant Terpenoids: Biosynthesis and Ecological Functions显示文摘在植物之中,第二等的代谢物 terpenoids 是在结构上很多样的组;他们直接在植物作为 phytoalex 在里面工作防卫,或作为在包含草食动物和他们的天敌的间接防卫回答的信号。在最近的年里,越来越多的注意对植物 terpenoids 的生态的角色的调查被给予了。单音的萜烯, sesquiterpenes ,和 diterpenes 的 Thebiosynthesis 小径包括 C5precursor isopentenyl diphosphate ( IPP )和它的 allylic 异构体 dimethylallyl diphosphate ( DMAPP )的合成,立即的 diphosphate 先锋的合成,并且多样的 terpenoids.Terpene synthases ( TPS )的形成在不稳定的萜烯合成起一个关键作用。由 TPSgenes 的表示,重要成就在新陈代谢的工程上被做了增加 terpenoidproduction。这评论主要在阐明总结最近的研究进步 terpenoids 的生态的角色和酶的描述在 terpenoid 生合成包含了。terpenoids 新陈代谢的空间、时间的规定也被讨论…… | Ai-Xia Cheng Yong-Gen Lou Ying-Bo Mao Shan Lu Ling-Jian Wang Xiao-Ya Chen | 2007 | Journal of Integrative Plant Biology2007，49，2： | 45 |
| 5 | Elevation of tumor necrosis factor-α,interleukin-1β and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes显示文摘有调停毒素的胰腺的损坏的背景大动物模型关于糖尿病 mellitus 和心血管的糖尿病的复杂并发症在研究广泛地被使用了。试图证实有 streptozotocin ( STZ )的中国贵州 minipig 模型导致了糖尿病并且描绘动物的现在的学习由在大动脉的墙中分析煽动性的 cytokine 层次当模特儿,例如肿瘤坏死因素( TNF ), interleukin-1 ( IL-1 )和 interleukin-6 ( IL-6 ) .Methods 22 男中国贵州 minipigs (变老, 4~6 个月;重量, 20 kg 到 30 kg ) 被划分成导致 STZ 的糖尿病的组(n=12 ) 和控制组(n=10 ) 。STZ (125 mg/kg ) 被管理导致多糖症,以后,胰岛素被用来在 10 mmol/L 下面控制 fasting 血葡萄糖层次。口头的葡萄糖忍耐测试(OGTT ) 以前被执行并且在 STZ 管理和丙氨酸 transaminase,天门冬素 transaminase,白朊,血脲氮, creatinine,类脂化合物和白色的浆液集中以后的一个月血房间计数以前并且六个月以后被测量。在六个月和胰为小岛房间 immunohistochemically 被检验以后,在两个组的动物是 euthanized。糖尿病的 minipigs 和控制的大动脉的 intima 在由西方的污点中等的调节的组织为 TNF- 水平被分析。在大动脉的 intima 的 TNF- , IL-1 和 IL-6 mRNA 层次是由反向的抄写和聚合酶链反应(RT-PCR ).Results 的 assayed 在浆液葡萄糖层次的重要举起被观察在 STZ 正式就职(P0.001 ) 和显著地增加的 OGTT 价值以后的一个月和六个月被注意,与基线数据相比。正常的胰有许多不规则的大小的小岛和小岛房间的小簇,当在糖尿病的 minipigs 的胰小岛房间几乎消失了时。没有统计差别以前在生物化学的考试的浆液集中被通知并且在 STZ 以后的六个月感应。西方的污点证明在 aotic intima 的戏剧性地增加的TNF-水平调节了TNF-, IL-1 和 IL-6 的中等、重要的举起 mRNA 层次被现在的学习建立了的 RT-PCR.Conclusions 揭示有 导致STZ 的 diabetes.Inflammatory cytokines 的中国贵州 minipig 模型(TNF-, IL-1 和 IL-6 )显著地在糖尿病的 minipigs 的大动脉的 intima 提高了。 | LU Lin ZHANG Qi PU Li-jin XU Xue-wei ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zheng-kun LU An-kang DING Feng-hua SHEN Jie CHEN Qiu-jin LOU Sheng FANG Dan-hong SHEN Wei-feng | 2007 | Chinese Medical Journal2007，，6： | 43 |
| 6 | Immunoregulatory Effects of Ethyl-acetate Fraction of Extracts from Tetrastigma Hemsleyanum Diels et. Gilg on Immune Functions of ICR Mice显示文摘Objective To evaluate the effects of ethyl-acetate fraction (EAF) of extracts from Tetrastigma hemsleyanum Diels et. Gilg (TDG) on immune functions of ICR mice. Methods ICR mice were exposed to different doses of EAF for 15 or 30 days and then their immune functions were analyzed, including ConA-induced splenic lymphocyte transformation, SRBC- induced delayed type hypersensitivity response, serum hemolysin analysis, antibody-producing cells, peritoneal macrophage phagocytized chicken red blood cells, natural killer cell activity, and serum level of cytokines. Results EAF of extracts from TDG at different doses had various effects on immune functions of ICR mice. As compared with the controls, it increased the mouse spleen lymphocyte transformation induced by ConA, the left-hind voix pedis thickness and the number of plague forming cells (PFCs) at the dose of 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the ink clearance ability at the dose of 0.91 mg/mL, 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the phagocytosis index of mononuclear-macrophages and production of serum interferon-gamma (IFN-γ) at the dose of 5.48 mg/mL; and could promote the production of serum tumor necrosis factor-alpha (TNF-α) at the dose of 9.12 mg/mL. Conclusion EAF of extracts from TDG can regulate mouse immune functions in vivo. | CAI-JU XU GANG-QIANG DING JIAN-YUN FU JIA MENG RONG-HUA ZHANG XIAO-MING LOU | 2008 | Biomedical and Environmental Sciences2008，21，4： | 49 |
| 7 | 地塞米松玻璃体腔植入剂治疗中国患者视网膜静脉阻塞继发黄斑水肿的安全性和有效性:随机、假注射对照、多中心研究显示文摘目的 评估地塞米松玻璃体腔植入物(DEX)治疗中国患者视网膜静脉阻塞继发黄斑水肿(RVO-ME)的安全性和有效性.方法 为期6个月的随机、双盲、假注射对照、多中心、3期临床研究,此后接续为期2个月的开放标签的延展研究.视网膜分支(BRVO)或中央静脉阻塞(CRVO)患眼于基线时接受DEX植入(n=129)或假注射(n=130)治疗;治疗后6个月时,两组中满足再治疗标准的全部患眼均再次接受DEX植入治疗.有效性变量包括最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CRT).BCVA检查采用早期治疗糖尿病视网膜病变研究组视力表进行.光相干断层扫描(OCT)检查采用德国Heidelberg公司Spectralis OCT仪或德国Zeiss公司Cirrus OCT仪进行.结果 治疗后6个月中(主要终点),DEX治疗组BCVA较基线提高≥15个字母的时间早于假注射组(P<0.001).治疗后第2个月时(效应峰值),DEX治疗组、假注射组BCVA较基线提高≥15个字母患者百分比分别为34.9%,11.5%.DEX治疗组、假注射组平均BCVA较基线分别提高(10.6±10.4)、(1.7±12.3)个字母;平均CRT分别较基线下降(407±212)、(62±224) μm (P<0.001).DEX治疗组CRVO、BRVO患眼治疗效果均优于假注射组.主要常见治疗相关不良事件为眼压升高,均可通过局部降眼压药物控制;无患者需要接受抗青光眼手术.结论 DEX治疗中国患者RVO-ME具有良好的安全性和显著的临床疗效;单次植入DEX较假注射可获得持续3-4个月的视力和解剖结构改善. | 黎晓新 王宁利 梁小玲 徐格致 Xiao-yan Li Jenny Jiao Jean Lou Yehia Hashad | 2018 | 中华眼底病杂志2018，34，3： | 41 |
| 8 | Colorectal cancer in Guangdong Province of China:A demographic and anatomic survey显示文摘AIM:To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province,China.METHODS:A review of patient records from 1986 to 2006 from five hospitals was conducted. Patient data was obtained,including age,gender,location of le-sions,staging and histological type of CRC. The Chi-square test was used to assess differences in rates and a significance level of 0.05 was used. Univariate com-parisons were made via Fisher's exact tests.RESULTS:Analysis was carried out on 8172 CRC patents,6.1% (499/8172) of the patients were aged ≤ 30 years. The peak incidence was between the ages 61-70 years (27.8%). The mean age at CRC diagnosis increased from 52 years (1986-1988) to 60 years(2004-2006) and the proportion of young CRC patients decreased from 8.0% to 5.9% over the same period. Of 8172 lesions,4434 (54.3%) were located in rectum and 3738 (45.7%) in colon. The incidence of rectal cancer decreased significantly from 59.4% (1989-1991) to 51.8% (2004-2006) and right sided colon cancer increased from 40.6% to 48.2%. The mean age,ana-tomic distribution,histological type and differentiation degree were significantly different among the four geographical areas (P < 0.05).CONCLUSION:The hospitalization rate for CRC has increased in Guangdong in recent years. The characteristics of CRC from the five hospitals located in the four different areas of Guangdong Province are also different. Further studies are needed to assess more recent trend in the incidence and prevalence of CRC as well as the respective roles of genetic and environ-mental factors in CRC. | Xu, An-Gao Yu, Zhi-Jin Jiang, Bo Wang, Xin-Ying Zhong, Xu-Hui Liu, Ji-Hong Lou, Qiu-Yun Gan, Ai-Hua | 2010 | World Journal of Gastroenterology2010，16，8： | 40 |
| 9 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 10 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 11 | Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: An endoscopist-blinded, prospective, randomized study显示文摘AIM: To assess the efficacy of premedicaton with pronase or N-acetylcysteine (NAC) at 20 min before upper gastrointestinal (UGI) endoscopy and to determine whether pronase or NAC pretreatment influences the reliability of the rapid urease test. METHODS: A total of 146 patients were prospectively and randomly assigned into the study groups according to different premedications before endoscopy. One endoscopist assessed mucosal visibility (MV) with scores ranged from 1 to 4 at four sites in the stomach. The sum of the MV scores from these four locations was defined as the total mucosal visibility (TMV) score. Identification of H pylori was performed using CLO test, histology, and serology. RESULTS: The Group with pronase premedication had a significantly lower TMV score than did the groups with gascon and gascon water (P < 0.001 and P < 0.01, respectively). The group with NAC had a significantly lower TMV score than the group with gascon (P < 0.01) and a trend of a lower MV score than the group with gascon water (P = 0.06). The TMV score did not significantly differ between the group with pronase and the group with NAC (P = 0.39 and P = 0.14, respectively). The sensitivity and specificity of the CLO test were 92.5% and 93.9%, respectively, in groups premedicated with pronase and NAC together.CONCLUSION: Premedication with pronase or NAC at 20 min before UGI endoscopy improves the mucosal visibility of the stomach. Neither pronase nor NAC produces any obvious interference with the CLO test for the identification of H pylori infection. | Chun-Chao Chang Sheng-Hsuan Chen Chih-Ping Lin Ching-Ruey Hsieh Horng-Yuan Lou Fat-Moon Suk Shiann Pan Ming-Shun Wu Jun-Nan Chen Yung-Fa Chen | 2007 | World Journal of Gastroenterology2007，13，3： | 31 |
| 12 | A Genetic Pathway for Tapetum Development and Function in Arabidopsis显示文摘In anther development, tapetal cells take part in complex processes, including endomitosis and apoptosis (programmed cell death). The tapetum provides many of the proteins, lipids, polysaccharides and other molecules necessary for pollen development. Several transcription factors, including DYT1, TDF1, AMS, MS188 and MS1, have been reported to be essential for tapetum development and function in Arabidopsis thaliana. Here, we present a detailed cytological analysis of knockout mutants for these genes, along with an in situ RNA hybridization experiment and double mutant analysis showing that these transcription factors form a genetic pathway in tapetum development. DYT1, TDF1 and AMS function in early tapetum development, while MS188 and MS1 are important for late tapetum development. The genetic pathway revealed in this work facilitates further investigation of the function and molecular mechanisms of tapetum development in Arabidopsis. | Jun Zhu Yue Lou Xiaofeng Xu Zhong-Nan Yang | 2011 | Journal of Integrative Plant Biology2011，53，11： | 32 |
| 13 | Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance显示文摘赤霉素(气体) 形成涉及植物生长和开发的许多方面的一组重要植物 tetracyclic diterpenoid 荷尔蒙。新兴的证据含有那气体也在压力回答起作用。然而,在关於生命的应力的气体的角色大部分是未知的。这里,我们报导那个大美人或 overexpression 伸长最高编码撤销的 GA 的 internode (Eui ) 基因分别地,酶损害或增加疾病抵抗到细菌的老家(Xanthomonas oryzae pv。oyrzae ) 并且米饭强风(Magnaporthe oryzae ) 。分别地, GA3 和 GA 合成(uniconazol ) 的禁止者的外长的申请能增加疾病危险性和抵抗到细菌的老家。同样, uniconazol 恢复了 eui 异种的疾病抵抗, GA3 减少了到细菌的老家的 Eui overexpressors 的疾病抵抗。因此,抵抗的变化把层次归因于 GA。在有这的一致性, GA 新陈代谢基因 OsGA20ox2 和 OsGA2ox1 在病原体挑战期间是下面调整的。我们也发现那 PR1a 正式就职被提高,但是 SA 水平在 Eui overexpressor 被减少,当 JA 水平在 eui 异种被减少时。一起,我们的当前的学习显示气体在米饭起一个否定作用基础疾病电阻,与是的 EUI 通过调整 bioactive 气体的水平的一个积极调节的人。 | Dong-Lei Yang Qun Li Yi-Wen Deng Yong-Gen Lou Mu-Yang Wang Guo-Xing Zhou Ying-Ying Zhang Zu-Hua He | 2008 | Molecular Plant2008，1，3： | 29 |
| 14 | Protective effects of ginsenoside Rb3 on oxygen and glucose deprivation-induced ischemic injury in PC12 cells显示文摘 | Jun-rong ZHU Yi-fu TAO Shen LOU Zi-mei WU | 2010 | Acta Pharmacologica Sinica2010，31，3： | 30 |
| 15 | 有限元分析法确定Johson-Cook本构方程材料参数显示文摘采用反演法确定了马氏体不锈钢410的Johnson-Cook本构方程材料参数.剪切实验采用的剪切速率为1~5000s-1,温度为20~1000℃.有限元模拟在Abaqus软件平台上进行.采用Johnson-Cook模型,施加与实验相同的初始条件.通过Matlab非线性最小二乘法优化程序来调整有限元模型材料参数,找到合适值,使得模拟得到的力-位移曲线与实验得到曲线相吻合.结果表明,所得参数都能很好地代表不锈钢410在高温高变形速度下的流动特性,Johnson-Cook模型不能描述材料破坏阶段的行为特征. | 董菲 Guenael Germain Jean Lou Lebrun 李铸国 | 2011 | 上海交通大学学报2011，45，11： | 30 |
| 16 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 17 | Genome-wide identification of CRISPR/Cas9 off-targets in human genome显示文摘 | Jinzhi Duan Guangqing Lu Zhan Xie Mingliang Lou Jiao Luo Lei Guo Yu Zhang | 2014 | Cell Research2014，24，8： | 27 |
| 18 | Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China显示文摘 | Wen-Jia Lou Bo Chen Lan Zhu Shao-Mei Han Tao Xu Jing-He Lang Lei Zhang | 2017 | Chinese Medical Journal2017，，12： | 25 |
| 19 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 20 | Directional Solidification Assisted by Liquid Metal Cooling显示文摘发展和液体金属冷却帮助的 directionalsolidification 过程( LMC )的当前的地位的概述在 LMC 过程的快速的发展的这 paper.Thedriving 力量被给出被考虑 thedemands 分析了( 1 )能提供更高热的坡度为的更新的技术减轻了 segregationin 先进合金系统,并且( 2 )更好的生产产量大方向性地 industrializa 的 solidifiedsuperalloy components.The | Jian ZHANG Langhong LOU | 2007 | Journal of Materials Science & Technology2007，23，3： | 24 |
您所在的机构暂未开通此部分的功能，请联系管理员