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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death显示文摘 | Festjens N van Gurp M van Loo G Saelens X Vandenabeele P | 2004 | Acta Haematol2004，111，2： | 1 |
| 3 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 4 | Occurrence of polar organic contaminants in the dissolved water phase of the Danube River and its major tributaries using SPE-LC-MS2 analysis 显示文摘 | LOOS R LOCORO G CONTINI S | 2010 | Water Res2010，44，7： | 1 |
| 5 | Curing of epoxy matrix composites 显示文摘 | LOOS A C SPRINGER G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 6 | Induction of B7-1in podocytes is associated with nephritic syndrome显示文摘 | Reiser J yon Gersdorff G Loos M | 2004 | J Clin Invest2004，113，10： | 1 |
| 7 | Dietary modulation of the human colonic microbiota:updating the concept of prebiotics显示文摘 | GIBSON G R PROBERT H M VAN LOO J | 2004 | Nutrition Research Reviews2004，17，2： | 1 |
| 8 | Curing of Epoxy Matrix Composites显示文摘 | Loos A C Springer G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 9 | LC-MS-MS analysis and occurfence of octyl-and nonylphenol, their ethoxylates and their carboxylates in Belgian and Italian textile industry, waste water and treatment plant effluents and surface waters 显示文摘 | Loos R Hanke G Umlauf G | 2007 | Chemosphere2007，66，4： | 1 |
| 10 | Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA显示文摘 | Kalai M Van Loo G Berghe TV | 2002 | Cell Death Differ2002，9，9： | 1 |
| 11 | Curcumin-induced GADD153 gene upregulation in human colon cancer cells 显示文摘 | LOO G SCOTT DW | 2004 | Carcinogenesis2004，25，11： | 1 |
| 12 | Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA显示文摘 | Johnson M K Loo G | 2000 | Mutation Research2000，459，3： | 1 |
| 13 | Pan-European survey on the occurrence of selected polar organic persistent pollutants in ground water显示文摘 | LOOS R LOCORO G COMERO S | 2010 | Water Research2010，44，14： | 1 |
| 14 | Deoxycholate induces DNA damage andapoptosis in human colon epithelial cell expressing either mutant orwild-type P53显示文摘 | Powolny A Xu J Loo G | 2001 | Int J Biochem Cell Biol2001，33，12： | 1 |
| 15 | High-QE-fast-readout wavefront sensor with analog phase reconstruction显示文摘 | Jeffrey T B Loos C G Restaino R S | 1998 | Proc SPIE1998，3353，： | 1 |
| 16 | EU-wide survey of polar organic persistent pollutants in European river waters 显示文摘 | LOOS R GAWTIK B M LOCORO G | 2009 | Environ Pollut2009，157，2： | 1 |
| 17 | Biological activities and mechanisms of action of A20(TNFAIP3)显示文摘 | Verstrepen L Verhelst K van Loo G | | 0，，： | 1 |
| 18 | Phase equilibria and critical phenomena in fluid(n-hexane+water)at high pressures and temperatures显示文摘 | de Loos Th W Penders W G Lichtenthaler R N | 1982 | The Journal of Chemical Thermodynamics1982，14，1： | 1 |
| 19 | Hepatic TNF signaling and NFkB : effects on liver homeostasis and beyond 显示文摘 | Wullaert A Van Loo G Heyninck K | 2007 | Endocr Rev2007，28，4： | 1 |
| 20 | Using secretion to solve a solubility problem:high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F显示文摘 | Loo T Patchett M L Norris G E | | 0，，： | 1 |
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