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| 1 | Optimization of rice wine fermentation process based on the simultaneous saccharification and fermentation kinetic model显示文摘Chinese rice wine making is a typical simultaneous saccharification and fermentation(SSF) process.During the fermentation process,temperature is one of the key parameters which decide the quality of Chinese rice wine.To optimize the SSF process for Chinese rice wine brewing,the effects of temperature on the kinetic parameters of yeast growth and ethanol production at various temperatures were determined in batch cultures using a mathematical model.The kinetic parameters as a function of temperature were evaluated using the software Origin8.0.Combing these functions with the mathematical model,an appropriate form of the model equations for the SSF considering the effects of temperature were developed.The kinetic parameters were found to fit the experimental data satisfactorily with the developed temperature-dependent model.The temperature profile for maximizing the ethanol production for rice wine fermentation was determined by genetic algorithm.The optimum temperature profile began at a low temperature of 26 °C up to 30 h.The operating temperature increased rapidly to 31.9 °C,and then decreased slowly to 18 °C at 65 h.Thereafter,the temperature was maintained at18 °C until the end of fermentation.A maximum ethanol production of 89.3 g·L^(-1)was attained.Conceivably,our model would facilitate the improvement of Chinese rice wine production at the industrial scale. | Dengfeng Liu Hongtao Zhang Chi-Chung Lin Baoguo Xu | 2016 | Chinese Journal of Chemical Engineering2016，24，10： | 10 |
| 2 | The timing of graphic, phonological and semantic activation of high and low frequency Chinese characters: An ERP study显示文摘二个事件相关的潜力(ERP ) 实验被执行比较高、低的频率 Chinesecharacters 的图形、语义、音韵学上的激活的时间功课。在实验 1,为高频率材料,当语义 priming 仅仅生产了更小的 N400 时,图形的 priming 生产了更小的 P200 andN400,但是与无关的对相比没有同音的 priming。在实验 2,为低频率材料,图形的 priming 生产了更小的 P200 和 N400,同音的 priming 生产了增加的 P200 和更小的 N400,语义 priming 与无关的对相比生产了中等减少的 N400。结果建议有激活高、低的 frequencyChinesecharacters 的词汇信息的一些差别。图形的激活首先出现,不管频率。为高频率人物,语义激活被发现,但是没有音韵学上的激活。而为低频率人物,,音韵学上的激活出现在语义激活前。 | Chen Baoguo Liu Ying Wang Lixin Peng Danling Charles A. Perfetti | 2007 | Progress in Natural Science:Materials International2007，17，B07： | 9 |
| 3 | Hydrogen generation with acid/alkaline amphoteric water electrolysis显示文摘To reduce the energy consumption of the electrolytic hydrogen generation process, we propose a novel approach to generate hydrogen with acidic/alkaline amphoteric water electrolysis, wherein hydrogen is produced inside an acidic solution and oxygen evolved under alkaline condition, and a membrane is employed in the middle of the electrolyzer to restrain neutralization. The electrode polarization is greatly reduced due to the specific arrangement of the acidic/alkaline amphoteric electrolyzer. The rate of hydrogen production achieves over four times higher than that of the alkaline aqueous solution at 2.2 V, and the energy consumption is reduced approximately 30% under the current density of 200 m A/cm ^2. The investigation of transmembrane potential drop indicates water splitting on the membrane surfaces, which compensates for acid or alkaline loss on-site and maintains the concentration approximately constant during electrolysis process. The acidic/alkaline amphoteric water electrolysis is promising as an energy saving, clean and sustainable hydrogen production technology. | Qing Lei Baoguo Wang Peican Wang Shuai Liu | 2019 | Journal of Energy Chemistry2019，28，11： | 8 |
| 4 | Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study显示文摘The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible. | Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju Yuhui Kou Lei Chen Mengxi Jiang Feng Pan Yali Zheng Zhancheng Gao Baoguo Jiang | 2020 | Bone Research2020，8，1： | 8 |
| 5 | Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum显示文摘 | Rongping Li Yebin Xi Xiuzhi Liu Guangjie Chen Baoguo Wang Lihua Jiang Weiyi Li | 2009 | Cellular & Molecular Immunology2009，6，3： | 8 |
| 6 | Time-dependent safety of lining structures of circular tunnels in weak rock strata显示文摘Following tunnel excavation and lining completion,fractured surrounding rock deforms gradually over time;this results in a time-dependent evolution of the pressure applied to the lining structure by the surrounding rock.Thus,the safety of the tunnel lining in weak strata is strongly correlated with time.In this study,we developed an analytical method for determining the time-dependent pressure in the surrounding rock and lining structure of a circular tunnel under a hydrostatic stress field.Under the proposed method,the stress–strain relationship of the fractured surrounding rock is assumed to conform to that of the Burgers viscoelastic component,and the lining structure is assumed to be an elastomer.Based on these assumptions,the viscoelastic deformation of the surrounding rock,the elastic deformation of the lining structure,and the coordinated deformation between the surrounding rock and lining structure were derived.The proposed analytical method,which employs a time-dependent safety coefficient,was subsequently used to estimate the durability of the lining structure of the Foling Tunnel in China.The derived attenuation curve of the safety coefficient with respect to time can assist engineers in predicting the remaining viable life of the lining structure.Unlike existing analytical methods,the method derived in this study considers the time dependency of the interaction between the surrounding rock and tunnel lining;hence,it is more suitable for the evaluation of lining lifetime. | Baoguo Liu Yu Song Zhaofei Chu | 2022 | International Journal of Mining Science and Technology2022，32，2： | 7 |
| 7 | The influence of synthetic jet excitation on secondary flow in compressor cascade显示文摘The detailed numerical simulation has been carried out to investigate the effect of synthetic jet excitation on the secondary flow at 5° incidence in a compressor cascade, in which the synthetic jet actuation is equipped on the suction surface. The influence of excitation position, one fixed near the trailing edge and the other fixed a little far from the trailing edge, has also been studied. The results show that unsteady disturbance of desirable synthetic jet effectively enhances the mixing of the fluid inside the separation region, which reduces the vortex intensity and the energy loss, improves the flow status in the cascade, and also suppresses velocity fluctuation near the trailing edge. Additionally, the actuation fixed near the separation region proves to be more effective and exit load distribution is more uniform due to the employment of the synthetic jet. | Yanming LIU, Tuo SUN, Chaobin GUAN and Baoguo WANG School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, China Assistant Professor | 2010 | Journal of Thermal Science2010，19，6： | 5 |
| 8 | A four-compartment model for the COVID-19 infection—implications on infection kinetics,control measures,and lockdown exit strategies显示文摘Objective:To analyse the impact and repercussions of the surge in healthcare demand in response to the COVID-19 pandemic,assess the potential effectiveness of various infection/disease control measures,and make projections on the best approach to exit from the current lockdown.Design:A four-compartment model was constructed for SARS-CoV-2 infection based on the Wuhan data and validated with data collected in Italy,the UK,and the US.The model captures the effectiveness of various disease suppression measures in three modifiable factors:(a)the per capita contact rate(β)that can be lowered by means of social distancing,(b)infection probability upon contacting infectious individuals that can be lowered by wearing facemasks,personal hygiene,etc.,and(c)the population of infectious individuals in contact with the susceptible population,which can be lowered by quarantine.The model was used to make projections on the best approach to exit from the current lockdown.Results:The model was applied to evaluate the epidemiological data and hospital burden in Italy,the UK,and the US.The control measures were identified as the key drivers for the observed epidemiological data through sensitivity analyses.Analysing the different lockdown exit strategies showed that a lockdown exit strategy with a combination of social separation/general facemask use may work,but this needs to be supported by intense monitoring whichwould allowre-introduction/tightening of the controlmeasures if the number of newinfected subjects increases again.Conclusions and relevance:Governments should act early in a swift and decisive manner for containment policies.Any lockdown exit will need to be monitored closely,with regards to the potential of lockdown reimplementation.This mathematical model provides a framework for major pandemics in the future. | Tianbing Wang Yanqiu Wu Johnson Yiu-Nam Lau Yingqi Yu Liyu Liu Jing Li Kang Zhang Weiwei Tong Baoguo Jiang | 2020 | Precision Clinical Medicine2020，3，2： | 5 |
| 9 | First evidence of prey capture and meat eating by wild Yunnan snub-nosed monkeys Rhinopithecus bieti in Yunnan,China显示文摘Most extant nonhuman primates occasionally prey on fast-moving, warm-blooded animals; however, Indriidae, Lepilemuridae,and Colobinae either scavenged for meat or did not eat meat at all. Here we report six cases of animal consumptionby the snub-nosed monkey Rhinopithecus bieti in a wild, habituated group between 2004 and 2009 in Yunnan, China. At present,only males in an all-male unit within the study group were involved in active hunting. Such a male-biased activity may be relatedto the group structure and spatial spread of R. bieti. Two females were observed eating freshly killed birds. The findings confirmedthat R. bieti engaged in scavenging and, when hunting, employed a cranio-cervical bite to kill their prey. Meat eating islikely a nutrient maximization feeding strategy in R. bieti, especially in males. A begging behavior occurred after successful preycapture. Although begging was observed, no sharing of the meat was seen. The present findings illuminate the dietary diversity ofR. bieti and their ability to expand their dietary | Baoping REN Dayong LI Zhijin LIU Baoguo LI Fuwen WEI Ming LI | 2010 | Current Zoology2010，56，2： | 4 |
| 10 | Analysis of Commonly and Specifically Dysregulated Pathways in Three Women Cancers显示文摘Breast, ovarian and endometrial cancer are three most prevalent gynaecological malignancies. Identifying their common and specific biomarkers is significant for cancer prediction and therapy in females. We propose a method to identify dysregulated pathways in cancer through scoring pathways based on the molecular interaction data and genomic data. Commonly and specifically dysregulated pathways are analyzed across the above three female cancers, which have not been studied as a whole to the best of our knowledge. Our results demonstrate that all the three cancers have close relationships with Type II diabetes and cell cycle-related biology processes. Breast cancer is specifically related to immune system while ovarian cancer and endometrial cancer are associated with blood vascular-related systems such as renin-angiotensin system and coagulation system. In addition, dysregulated pathways are used to predict potential driver genes effectively according to their topological structure and biological information. | LIU Xiyang AN Yingying YU Baoguo QIN Guimin | 2018 | Chinese Journal of Electronics2018，27，5： | 4 |
| 11 | Discussion on the Application of LS-DYNA in Superfine Grinding of Wheat Bran显示文摘Superfine grinding, involving the fragmentation mechanism of wheat bran cell tissue, is being employed by milling industry. In order to determine the effect of wheat bran cell tissue on the fragmentation mechanism when using superfine grinding,a technical scheme of the nonlinear finite element numerical simulation method based on LS-DYNA is proposed in this paper.The physiological characteristics of wheat bran structural layers including outer pericarp, intermediate layer and aleurone layer are examined first, and then the mechanical properties of wheat bran structural layers and their effects on the super fine grinding process are analyzed. Secondly, the explicit time integration algorithm of LS-DYNA is introduced, and the application feasibility of LS-DYNA in the analysis of wheat bran superfine grinding mechanism is discussed. Finally, the specific application of LS-DYNA in the determination of grinding form and load, the selection and design of the grinding media and the selection of grinding temperature are discussed in detail in the process of superfine grinding for wheat bran cell tissue. The above research provides a theoretical basis for selecting and developing the equipment and technology suitable for wheat bran superfine grinding, and lays a theoretical foundation for enhancing the quality and efficiency of wheat bran superfine grinding. | CHENG Min LIU Baoguo CAO Xianzhou | 2018 | Grain & Oil Science and Technology2018，1，3： | 3 |
| 12 | Human activities and elevational constraints restrict ranging patterns of snub-nosed monkeys in a mountainous refuge显示文摘Both natural conditions and anthropogenic factors affect the survivability,distribution,and population density of wildlife.To understand the extent and how these factors drive species distributions,a detailed description of animal movement patterns in natural habitats is needed.In this study,we used satellite telemetry to monitor elevational ranges favored by endangered golden snub-nosed monkeys(Rhinopithecus roxellana),in the Qinling Mountains,central China.We investigated the abundance and distribution of food resources through sampling vegetation quadrats at different elevations and sampled anthropogenic activities using field surveys.Our results indicated that although there was no significant variation in food resources between low-(<1500 m)and middle-elevations(1500–2200 m),monkeys were found most often in areas above 1500 m,where there was less anthropogenic development(e.g.houses and roads);however,monkeys rarely ranged above 2200 m and had limited food availability at this altitude.There was limited human disturbance at this elevation.We suggest that both human activity and ecological constraints(i.e.food resources)have considerable effects on elevational use of R.roxellana in the Qinling Mountains.This study highlights the critical roles these factors can play in shaping the vertical distribution of high-altitude primates.This research provides useful insights for habitat-based conservation plans in which human disturbance management and habitat restoration should be prioritized. | Pengzhen HUANG Kun BIAN Zhipang HUANG Qi Li Derek WDUNN Gu FANG Jiahui LIU Mengyao WANG Xianfeng YANG Ruliang PAN Cunlao GAO Kaichuang SI Baoguo LI Xiaoguang QI | 2021 | Integrative Zoology2021，16，2： | 3 |
| 13 | Effects of Dietary Crude Fiber Levels on Growth Performance and Serum Biochemical Index of Dingan Geese Aged from 35 to 70 Days显示文摘[Objective] The study was carried out to investigate the effects of dietary crude fiber on growth performance and serum biochemical in-dex of Dingan geese aged from 35 to 70 days.[Method] A total of 120 Dingan geese on day 28 with the same genetic background and similar initial weight(1 384.83.73±0.76 g) were randomly assigned into 3 groups, with 4 replicates per group and 10 geese per replicate. Geese were fed the diets containing 4.29%, 5.29% and 6.29 % crude fiber, respectively. The experiment lasted 35 d.[Result] Final weight and daily gain of 5.29 %CF group were significantly higher than those of 6.29 % CF group(P<0.05);Feed intake was markedly higher than those of 4.29% and 6.29 % CF groups(P<0.05);Feed gain ratio was significantly lower than that of 6.29 % CF group(P<0.05). Compared with 4.29% and 6.29 % CF groups, serum albumin concentrations of 5.29 % CF group increased significantly(P<0.05), while serum total protein and globin contents were higher(P>0.05), but serum uric acid level was lower(P>0.05).[Conclusion] 5.29 % crude fiber could lead to higher growth performance of Dingan geese. | Liu Quanwei Wang Feng Wei Limin Lin Dajie Xing Manping Yang Shaoxiong Sun Ruiping Ye Baoguo | 2019 | Animal Husbandry and Feed Science2019，11，1： | 3 |
| 14 | Unidirectional acoustic transmission in asymmetric bull's eye structure显示文摘Unidirectional acoustic transmission has been investigated in an asymmetric bull's eye structure, which consistes of a subwavelength hole with concentric grooves on one side of a thin steel plate. When acoustic waves impinge normally on the groove side of the asymmetric structure, a strong acoustic transmitted energy flux is observed in the frequency range of 400–450 k Hz, while there is no obvious transmitted energy flux in the same frequency range if the acoustic waves impinge normally on the other side. Thus, a remarkable unidirectional acoustic transmission behavior is exhibited by the current structure. With changing the period of the grooves, it is found that the transmitted acoustic energy flux keeps unchanged while the frequency of the transmitted waves can be modified. The experiments are performed, which has confirmed the unidirectional acoustic transmission behavior in the asymmetric bull's eye structure. The asymmetric bull's eye structure may have potential application in ultrasound diagnosis and therapy. | WANG JiWei YUAN BaoGuo CHENG Ying LIU XiaoJun | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，2： | 3 |
| 15 | A thermoresponsive composite separator loaded with paraffin@SiO_(2) microparticles for safe and stable lithium batteries显示文摘Lithium-ion batteries (LIBs)-related accidents have been reported for years and safety issues are stumbling blocks for the practical applications of lithium metal batteries (LMBs) with higher energy density. More effective strategies to shut down the battery at the early stage of thermal runaway with less side effects on the electrochemical performance are greatly desired. In this work, the core–shell structural paraffin@SiO_(2) microparticles were synthesized by in situ emulsion interfacial hydrolysis and polycondensation and the paraffin@SiO_(2)-loaded separator (PSS) was prepared by a facile filtration method. The introduction of hydrophilic silica shells in paraffin@SiO_(2) enhanced the wettability of carbonate electrolyte with the composite separator and improved the processability of soft paraffin. As a result, when used in LMBs at room temperature, the cell with PSS inside had a more uniform deposition of lithium, a much lower overpotential and a more stable electrochemical performance than the cell with the blank separator or the conventional pure paraffin-loaded separator inside. More significantly, when a heating stimulation (i.e. 115 ℃) was subjected to the cell with PSS inside, the paraffin in the core of paraffin@SiO_(2) could be released, blocking the gaps between particles and the pores in the separator and efficiently stopping the transportation of Li+ between two electrodes, resulting in the thermally-induced shutdown of the cell below the melting temperature of PE (~135 ℃) in the Celgard2325 separator. The core–shell structure of paraffin@SiO_(2) enables the maintaining of each component’s benefits while avoiding each one’s drawbacks by elaborating microstructural design. Therefore, the conventional dilemma between the electrochemcial performance and safety of LMBs could be solved in the future. | Hao Dong Peican Wang Shuaishuai Yan Yingchun Xia Baoguo Wang Xiaolin Wang Kai Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
| 16 | Biomimetic Chiral Pyridoxal and Pyridoxamine Catalysts显示文摘What is the most favorite and original chemistry developed in your research group? Vitamin B6-based biomimetic asymmetric catalysis. How do you get into this specific field? Could you please share some experiences with our readers? Enzymatic transformations are characterized by high efficiency, specific selectivities, and mild conditions, which attracts me to do some chemistry related to biological systems. | Jianfeng Chen Yong Ethan Liu Xing Gong Limin Shi Baoguo zhao | 2019 | Chinese Journal of Chemistry2019，37，2： | 3 |
| 17 | A COVID-19 Outbreak—Nangong City,Hebei Province,China,January 2021显示文摘Summary What is known about this topic?Coronavirus disease 2019(COVID-19)is widespread globally.In China,COVID-19 has been well controlled and has appeared only in importationrelated cases.Local epidemics occur sporadically in China and have been contained relatively quickly.What is added by this report?Epidemiological investigation with genome sequence traceability analysis showed that the first case of COVID-19 in Nangong City acquired infection from a confirmed case from Shijiazhuang City. | Shiwei Liu Shuhua Yuan Yinqi Sun Baoguo Zhang Huazhi Wang Jinxing Lu Wenjie Tan Xiaoqiu Liu Qi Zhang Yunting Xia Xifang Lyu Jianguo Li Yan Guo | 2021 | China CDC weekly2021，3，19： | 3 |
| 18 | Development of a reverse transcription quantitative polymerase chain reaction-based assay for broad coverage detection of African and Asian Zika virus lineages显示文摘The Zika virus(ZIKV) is an arbovirus that has spread rapidly worldwide within recent times. There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome(GBS) and microcephaly in humans. The ZIKV is genetically diverse and can be separated into Asian and African lineages. A rapid, sensitive, and specific assay is needed for the detection of ZIKV across various pandemic regions. So far, the available primers and probes do not cover the genetic diversity and geographic distribution of all ZIKV strains. To this end, we have developed a one-step quantitative reverse transcription polymerase chain reaction(qRT-PCR) assay based on conserved sequences in the ZIKV envelope(E) gene. The detection limit of the assay was determined to be five RNA transcript copies and 2.94 × 10^(–3) 50% tissue culture infectious doses(TCID50) of live ZIKV per reaction. The assay was highly specific and able to detect five different ZIKV strains covering the Asian and African lineages without nonspecific amplification, when tested against other flaviviruses. The assay was also successful in testing for ZIKV in clinical samples. Our assay represents an improvement over the current methods available for the detection ZIKV and would be valuable as a diagnostic tool in various pandemic regions. | Yang Yang Gary Wong Baoguo Ye Shihua Li Shanqin Li Haixia Zheng Qiang Wang Mifang Liang George F Gao Lei Liu Yingxia Liu Yuhai Bi | 2017 | Virologica Sinica2017，32，3： | 3 |
| 19 | Effects of hydrogenation temperature on room-temperature compressive properties of CMHT-treated Ti6Al4V alloy显示文摘Compression tests were performed at room temperature to investigate the effects of hydrogenation temperature on compressive properties of Ti6 Al4 V alloy treated by continuous multistep hydrogenation treatment(CMHT).Pressure-composition isotherms and micro structures were also studied.Results showed that the equilibrium hydrogen pressure increased,and the hydrogen absorption rate decreased with the increase of hydrogenation temperature.The amounts ofβphase andα'martensite increased first and then decreased when Ti6 Al4 V alloy was treated by four times CMHT with the increase of hydrogenation temperature.Hydrogenation temperature played a different role on the compressive properties of CMHT-treated Ti6 Al4 V alloy.The ultimate compression of Ti6 Al4 V alloy treated by 11 times CMHT at850℃increased by 83.3%as compared to the as-received Ti6 Al4 V alloy.The compressive properties of Ti6 Al4 V alloy were dependent on the amounts of different phases and microstructures when Ti6 Al4 V alloy was treated by CMHT at different temperatures. | Baoguo Yuan Xing Liu Jiangfei Du Qiang Chen Yuanyuan Wan Yunliang Xiang Yan Tang Xiaoxue Zhang Zhongyue Huang | 2021 | Journal of Materials Science & Technology2021，，13： | 3 |
| 20 | The Effect of the MDM2-p53 Loop on the Sensitivity of Ovarian Cancer Cells to Cisplatin显示文摘OBJECTIVE To explore whether MDM2 transfection can alter the MDM2-p53 autoregulatory feedback loop so as to change the sensitivity of ovarian cancer cell lines to cisplatin. METHODS The ovarian cancer cell line A2780 expressing wild-type P53 and the ovarian cancer cell line SKOV-3 with the p53 null type were stably transfected with pCMV-MDM2 or pCMV as a control. The blocked expression of P53 was determined by Western blots. Cytotoxicity was assessed using the MTT assay and the trypan blue exclusion assay. Flow cytometry was used to detect changes in the cell cycle and removal of platinum -DNA adducts was measured by atomic absorption spec-troscopy. RESULTS (1) Parental A2780 and A2780-V cells (IC50= 15.14±1.39 μmol) have similar cisplatin sensitivities, whereas sensitivity to cisplatin in A2780-M cells (IC50=7.98±1.32 μmol) was 2 to 3 fold greater (P=0.001). The trypan blue exclusion assay demonstrated that cisplatin killed a higher percentage of A2780-M cells compared to A2780-V cells. There was no significant change following MDM2 transfection in SKOV-3 cells. (2) After cisplatin treatment, A2780-M cells showed a pronounced S-phase arrest, however, A2780 cells with the intact wild-type P53, arrested primarily at the G2/M transition. (3) Platinum uptake was similar for all of the A2780 cell lines after ciaplatin treatment, but the removal of plat-inum-DNA adducts was reduced in the A2780-M cells compared with A2780-V cells. CONCLUSION MDM2 increases cisplatin cytotoxicity in ovarian cancer cells by blocking the expression of p53 through the MDM2-p53 autoregulatory feedback loop. | Zhi Guo Hong Ni Bin Li Wenge Xing Fang Liu Haipeng Yu Baoguo Li Xiuying Guo | 2006 | Chinese Journal of Clinical Oncology2006，3，2： | 2 |
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