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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | 感染兽类和人类的冠状病毒--控制疫情需要对它们的生物学和行为有详细的了解显示文摘冠状病毒已经存在了很多年,首次发现于20世纪60年代。这些病毒包括引起普通感冒的冠状病毒(HCoV-229E)和各种兽类与鸟类冠状病毒,例如可以感染家禽的传染性支气管炎病毒(infectious bronchitis virus,IBV)。冠状病毒通常会引起呼吸道或者胃肠道疾病,但是一些IBV毒株已证明能破坏鸡的输卵管,而其他的毒株可引起严重的肾脏疾病。 | Ng Lisa F P Hiscox Julian A 哈飞再(译者) 郑湃(审校者) | 2020 | 英国医学杂志中文版2020，23，6： | 4 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Synthesis and characterisation of day-supported titania photocatalysts显示文摘 | Lisa M D Ray L F Huai Y Z | | 0，，： | 1 |
| 5 | The structure of self-consciousness in children and young adolescents and relations to social anxiety显示文摘 | Charmaine K Higa Lisa K Phillips Bruce F Chorpita | 2008 | Journal of Psychopathology and Behavioral Assessment2008，30，4： | 1 |
| 6 | Complications in breast surgery显示文摘 | Angelique F Vitug Lisa A | 2007 | Surg Clin N Am2007，87，： | 1 |
| 7 | Phosphate availability regulates root system architecture in Arabidopsis 显示文摘 | LISA C W SEBASTIEN P C R R ALASTAIR H F | 2001 | Plant Physiol2001，，126： | 1 |
| 8 | A critical review of ohmic and rectifying contacts for silicon carbide 显示文摘 | Porter Lisa M Davis Robert F | 1995 | Materials Science and Engineering B1995，34，23： | 1 |
| 9 | Use of hyperspectral images in the identification and mapping of expansive clay soils and the role of spatial resolution显示文摘 | SABINE CHABRILLAT ALEXANDER F H GOETZ LISA KROSLEY | 2002 | Remote Sensing of Environment2002，82，： | 1 |
| 10 | A Real-time Hulti-agent System Archltecture for E-commerce Applications显示文摘 | Lisa C D Victor F W LekshmiN | 2000 | Computer StandardS & Interfaces2000，，22： | 1 |
| 11 | Participation in cognitively stimulating activities and risk of incident Alzheimer disease显示文摘 | Robert S Wilson Carlos F Mendes De Leon Lisa L Barnes | 2002 | JAMA2002，287，6： | 1 |
| 12 | Detection of severe acute respiratory syndrome coronavirus in blood of infected patients 显示文摘 | Lisa F P N Michelle W Susie K | 2004 | J Clin Microbiol2004，42，1： | 1 |
| 13 | X-Efficiency in the US life insurance industry显示文摘 | Gardner Lisa A Grace Martin F | 1993 | Journal of Banking & Finance1993，4，： | 1 |
| 14 | Reactive oxygen species and redox compartnmntalization显示文摘 | KALUDERCIC N DESHWAL S DI LISA F | 2014 | Front Physiol2014，5，： | 1 |
| 15 | Beta(2)-Adrenoceptors,NADPH oxidase,ROS and p38MAPK:another ‘radical’ road to heart failure?显示文摘 | DI LISA F KALUDERCIC N PAOLOCCI N | 2011 | Br JPharmacol2011，162，5： | 1 |
| 16 | Severe recurrent ureteral stricture: the combined use of an anterograde and retrograde approach in the prone split-leg position without X-rays显示文摘 | Cossu F M De Lisa A | 1997 | Eur Urol1997，31，2： | 1 |
| 17 | Effects of onset of labor and mode of delivery on severe postpartum hemorrhage 显示文摘 | Iqbal AZ Siri V Lisa F | 2009 | Am J Obstet Gynecol2009，201，273： | 1 |
| 18 | Mitochondria and cardioprotection 显示文摘 | di Lisa F Canton M Menabb R | 2007 | Heart Fail Rev2007，12，： | 1 |
| 19 | Autologous fat grafting improves facial nerve function显示文摘 | Klinger M Lisa A Caviggioli F | 2015 | Case Rep Surg2015，2015，52： | 1 |
| 20 | Isolation, modification, and NMR assignments of a series of cellulose oligomers 显示文摘 | LISA A F JARRED T B PETER A P | 1999 | Journal of the American Chemical Society1999，121，： | 1 |
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