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| 1 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 2 | A numerical model eoupling the heat and gas species' transport processes in a tubular SOFC显示文摘 | LIP W SCHAEFER L CHYU M K | 2004 | J Heat Transfer2004，126，： | 1 |
| 3 | Plasma matrix metal- loproteinase-9,tissue inhibitor of metalloproteinase-2,and CD40 ligand levels in patients with stable coronary artery dis- ease显示文摘 | Tayebjee M H Lip G Y Tan K T | 2005 | Am J Cardiol2005，96，3： | 1 |
| 4 | Quality of life in patients with osteoporosis显示文摘 | Lips P vanSchoor N M | 2005 | Osteoporos Int2005，16，： | 1 |
| 5 | Involvement of abscisic acid in potato cold acclimation 显示文摘 | CHEN H H LIP H BRENNER M L | 1983 | Plant Physiol1983，71，1： | 1 |
| 6 | The effect of frailty on residential/nursing home admission in the Netherlands independent of chronic diseases and functional limitations显示文摘 | Puts M T E Lips P Ribbe M W | 2005 | European Journal of Ageing2005，2，26： | 1 |
| 7 | Textural and sensory properties of salted noodles containing purple yam flour显示文摘 | LIP H HUANG C C YANG M Y | 2012 | Food Research International2012，47，： | 1 |
| 8 | Remote sensing image-based analysis of the relationship between urban heat island and land use/cover changes显示文摘 | CHEN X L ZHAO H M LIP X | 2006 | Remote Sensing of Environment2006，104，2： | 1 |
| 9 | Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei显示文摘 | Berberof M Pays A Lips S | | 0，，03： | 1 |
| 10 | Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women 显示文摘 | BOIVIN G LIPS P OTT S M | 2003 | J Clin Endocrinol Metab2003，88，9： | 1 |
| 11 | A giant ubiquitinconjugating enzyme related to IAP apoptosis inhibitors显示文摘 | Hauser liP Bardroff M Pyrowolakis G | 1998 | J Cell Biol1998，141，： | 1 |
| 12 | Physical properties of the inside ligament of the scallop shell显示文摘 | KITAGAWA M LIP | 2004 | J Mater Sci2004，39，22： | 1 |
| 13 | Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response显示文摘 | Lips E H Michaut M Hoogstraat M | 2015 | Breast Cancer Res2015，17，1： | 1 |
| 14 | Sponta- neous delivery duringveno - venous extracor- poreal membrane oxygenation in swineinfluen- za - related acute respiratory failure 显示文摘 | Kunstyr J Lips M Belohlavek J | 2010 | Acta AnaesthesiolScand2010，54，9： | 1 |
| 15 | How to maintain surveillance for novel influenza A H1 N1 when there are too many cases to count显示文摘 | LIP SITCH M HAYDEN F G COWLING B J | 2009 | Lancet2009，374，9696： | 1 |
| 16 | Endoge-nous subclinical thyroid disorders, physical and cognitivefunction,depression,and mortality in older individuals 显示文摘 | de JONGH R T LIPS P van SCHOOR N M | 2011 | Eur J Endocrinol2011，165，4： | 1 |
| 17 | Multiple sclerosis and vitamin D:an update显示文摘 | VanAmerongen B M Dijkstra C D Lips P | 2004 | Eur J Clin Nutr2004，58，8： | 1 |
| 18 | Adiponectin: more than just another fat cell hormone 显示文摘 | Chandran M Phi/lips SA Ciaraldi T | 2003 | Diabetes Care2003，26，8： | 1 |
| 19 | Salinity and nitrogen nutrition studies on peanut and cotton plants显示文摘 | Leidi E O Silberbush M Soares M M Lips S H | 1992 | Journal of Plant Nutrition1992，15，5： | 1 |
| 20 | Circulating endothelial cells von Willebr factor interleukin and prognosis in patients with acute coronary syndromes 显示文摘 | Lee KW Lip GY Taybje M | 2005 | Blood2005，105，： | 1 |
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