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| 1 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 2 | Lanthanide-doped heterostructured nanocomposites toward advanced optical anti-counterfeiting and information storage显示文摘The continuously growing importance of information storage,transmission,and authentication impose many new demands and challenges for modern nano-photonic materials and information storage technologies,both in security and storage capacity.Recently,luminescent lanthanide-doped nanomaterials have drawn much attention in this field because of their photostability,multimodal/multicolor/narrowband emissions,and long luminescence lifetime.Here,we report a multimodal nanocomposite composed of lanthanide-doped upconverting nanoparticle and EuSe semiconductor,which was constructed by utilizing a cation exchange strategy.The nanocomposite can emit blue and white light under 365 and 394 nm excitation,respectively.Meanwhile,the nanocomposites show different colors under 980 nm laser excitation when the content of Tb3+ions is changed in the upconversion nanoparticles.Moreover,the time-gating technology is used to filter the upconversion emission of a long lifetime from Tb3+or Eu3+,and the possibilities for modulating the emission color of the nanocomposites are further expanded.Based on the advantage of multiple tunable luminescence,the nanocomposites are designed as optical modules to load optical information.This work enables multi-dimensional storage of information and provides new insights into the design and fabrication of next-generation storage materials. | Yao Xie Yapai Song Guotao Sun Pengfei Hu Artur Bednarkiewicz Lining Sun | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 3 | Pitting Corrosion of 13Cr Steel in Oxygen-free Completion Fluids of Organic Salt显示文摘Corrosion behavior of 13Cr steel in oxygen-free completion fluids of the organic salt at 180 ℃ was studied. Cross-sectional morphologies of the corrosion products were observed by scanning electron microscopy. Energy dispersive spectrum (EDS) was used to study the element distribution of the corrosion product inside and outside the pits. The results show that the organic salt causes severe pitting corrosion of 13Cr steel. The width and depth of the pits increase simultaneously when the test duration prolongs, and potassium enriches inside the pits. | Lining XU Yao MENG Yunguang SHI Yan LIU | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，3： | 2 |
| 4 | Proceedings of the international conference on fiber reinforced concrete显示文摘 | SHIEN LI GUIHUI WEI LINING YAO | 1997 | Guangzhou:Guangdong Science and Technology Press1997，2733，： | 1 |
| 5 | Bond-graph model of a piezostack driven jetting dispenser显示文摘 | Shizhou Lu Yaxin Liu Yufeng Yao Lining Sun Ming Zhong | 2014 | Simulation Modelling Practice and Theory2014，，： | 1 |
| 6 | Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment显示文摘Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes and massive infiltration of inflammatory immune cells.Recent studies showed that Signal Transducer and Activator of Transcription 3(STAT3),which plays an important role in cell survival,proliferation,differentiation,angiogenesis,and immune responses,is constitutively activated in epidermal keratinocytes of human psoriatic skin lesions.In addition,STAT3 promotes the differentiation and expansion of T cells and facilitates cytokine production,thereby exacerbating the condition of psoriasis.Alantolactone(ALT)is a sesquiterpene lactone compound that could selectively suppress STAT3 activation,but its effectiveness and application in psoriasis treatment have not been determined.In this study,we developed ALT loaded chitosan/hyaluronic acid nanoparticles(CHALT),and investigated its therapeutic potential for psoriasis therapy.CHALT effectively abrogated the hyperproliferation by inducing ROS-mediated apoptosis with loss of mitochondrialmembrane potential,and also inhibited IL-6-induced STAT3 signaling activation and inflammatory reaction in HaCaT cell line.In an Imiquimod(IMQ)-induced psoriasis model,the topical treatment of psoriasis lesions with CHALT effectively attenuated the STAT3 hyperactivation within keratinocytes and ameliorated the symptoms of psoriasis.In addition,it was found that CHALT restricted the recruitment of immune cells.These results indicated that ALT-based nanoformulation CHALT holds great potential for psoriasis therapy. | Ruijie Chen Yuan-Yuan Zhai Lining Sun Zeqing Wang Xing Xia Qing Yao Longfa Kou | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 1 |
| 7 | Nd^(3+)-sensitized upconversion nanoparticle coated with antimony shell for bioimaging and photothermal therapy in vitro using single laser irradiation显示文摘Combining treatment and diagnosis,called theranostics,which is achieved within single nanoparticle is an ultimate goal of many studies.Herein,we developed a new nanotheranostic agent-Nd^(3+)-sensitized upconversion nanoparticles core for dual modal imaging(i.e.,upconversion luminescence imaging and magnetic resonance imaging) and antimony nanoshell for photothermal therapy(PTT).The core-shellshell upconversion nanoparticles(NaYF_(4):Yb,Er@NaYF_(4):Yb,Nd@NaGdF_(4):Nd,named as UCNP) were firstly synthesized using thermal decomposition method and then were coated by antimony shell over the surface of UCNP using simple cost and time effective new method.Furthermore,the surface of UCNP@Sb nanostructures was modified with DSPE-PEG in order to enhance the water solubility and biocompatibility.The final nanotheranostic agent,named as UCNP@Sb-PEG,exhibits very low toxicity,good biocompatibility,very good photothermal therapeutic effect,and efficient upconversion luminescence(UCL) imaging of HeLa cells under only one laser(808 nm) irradiation.The antimony shell is quenching the upconversion emission in pristine nanotheranostic agent,but interestingly,the UCL intensity of the agent recovers progressively under 808 nm laser irradiation due to light induced degradability of antimony shell.Besides,high longitudinal relaxivity(r_(1)) obtained from the experiment approves excellent potential of the nanotheranostic agent for T_(1)-weighted magnetic resonance imaging application. | Solomon Tiruneh Dibaba Yao Xie Wensong Xi Artur Bednarkiewicz Wei Ren Lining Sun | 2022 | Journal of Rare Earths2022，40，6： | 1 |
| 8 | Carbon/Aramid hybrid fabrics for reinforced concrete construction显示文摘 | Lining Yao Wenwei Wu Yizhen Jiang | 1997 | International Conference on Fiber Reinforced Concrete1997，，： | 1 |
| 9 | Exploring luminescence quenching on lanthanide-doped nanoparticles through changing the spatial distribution of sensitizer and activator显示文摘Luminescence quench is common in overdoped upconversion nanoparticles.Various methods have been proposed to counteract the adverse effects of concentration quenching on luminescence,but in upconversion nanoparticles that are highly doped with both sensitizers and activators,the factors that contribute to the diminishing of the emission cannot be summarized by a single cause.Herein,a core-shell design is used to spatially separate the sensitizer(Yb^(3+))and activator(Er^(3+))and to modulate the emission by changes in the distribution position as well as the concentration of the dopant ions in order to probe the factors affecting the luminescence.When the sensitizer ions are located in the core,the luminescence intensity of the nanoparticles is significantly weaker than that of the other distribution,which implies that the effect of sensitizer and activator on luminescence in the highly doped state has a different and more complex mechanism.The intensity of the emission is more affected by Yb^(3+)than Er^(3+),which includes not only the self-quenching of Yb^(3+),but also the dominance in the Yb^(3+)-Er^(3+)cross-relaxation.In this finding may provide new ideas for revealing the reasons for the diminished luminescence of highly doped upconversion nanoparticles and thus for enhancing luminescence. | Jiwei Li Yao Xie Renrui Sun Junxun Zhou Lining Sun | 2024 | Nano Research2024，17，5： | 0 |
| 10 | Water-responsive gel extends drug retention and facilitates skin penetration for curcumin topical delivery against psoriasis显示文摘Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment. | Qing Yao Yuanyuan Zhai Zhimin He Qian Wang Lining Sun Tuyue Sun Leyao Lv Yingtao Li Jiyong Yang Donghui Lv Ruijie Chen Hailin Zhang Xiang Luo Longfa Kou | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，2： | 0 |
| 11 | In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke显示文摘In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment. | Meng Yuan Yao Tang Tianwen Huang Lining Ke En Huang | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 12 | General modeling and optimization technique for real-world earth observation satellite scheduling显示文摘Over the last two decades,many modeling and optimization techniques have been developed for earth observation satellite(EOS)scheduling problems,but few of them show good generality to be engineered in realworld applications.This study proposes a general modeling and optimization technique for common and real-world EOS scheduling cases;it includes a decoupled framework,a general modeling method,and an easy-to-use algorithm library.In this technique,a framework that decouples the modeling,constraints,and optimization of EOS scheduling problems is built.With this framework,the EOS scheduling problems are appropriately modeled in a general manner,where the executable opportunity,another format of the well-known visible time window per EOS operation,is viewed as a selectable resource to be optimized.On this basis,10 types of optimization algorithms,such as Tabu search and genetic algorithm,and a parallel competitive memetic algorithm,are developed.For simplified EOS scheduling problems,the proposed technique shows better performance in applicability and effectiveness than the state-of-the-art algorithms.In addition,a complicatedly constrained real-world benchmark exampled by a four-EOS Chinese commercial constellation is provided,and the technique is qualified and outperforms the in-use scheduling system by more than 50%. | Feng YAO Yonghao DU Lei LI Lining XING Yingguo CHEN | 2023 | Frontiers of Engineering Management2023，10，4： | 0 |
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