|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 2 | Do cyanobacteria dominate in eutrophic lakes because they fix atmospheric nitrogen?显示文摘 | FERBER L R LEVINE S N LINI A | 2004 | Freshwater Biology2004，49，： | 1 |
| 3 | Isotopic signature of nitrate in two contrasting watersheds of Brush Brook, Vermont, USA显示文摘 | HALES H C ROSS D S LINI A | 2007 | Biogeochemistry2007，84，： | 1 |
| 4 | 10000 yr record extreme hydrological events 显示文摘 | Brown S L Bierman P R Lini A | 2000 | Geology2000，28，： | 1 |
| 5 | Indocyanine green angiographic findings in multifocal choroidopathies显示文摘 | Giovannini A Sforzo lini B D' altobrando E | 1996 | Bull Soc Belge Ophthalmol1996，263，： | 1 |
| 6 | Incidence and mechnism of creatine kinase-MB enzyme elevation after coronary intervention with different devices显示文摘 | KINI A LINI S MARMUR J | 1999 | Cathet Cardiovasc Interv1999，48，： | 1 |
| 7 | Karyotype of the Lygosomine genus Ateuchosaurus from East Asia 显示文摘 | OTA H LINi J T BOGADEK A | 1997 | Journal of Herpetology1997，31，4： | 1 |
| 8 | Land surface temperature retrieval from landsat TM5 显示文摘 | Sobrinoa J A Jim 6nez-M unoz J C Pao lini L | 2004 | Remote Sensin of Environment2004，90，4： | 1 |
| 9 | The Valanginian carbon isotope event:A first episode of greenhouse climate conditions during the Cretaceous显示文摘 | Lini A Weissert H Erba E | 1992 | Terra Nova1992，4，： | 1 |
| 10 | Peripheral neuropathy induced by intravenous administration of vincristine sulfate in the rabbit显示文摘 | Fiori MG Schiavinato A Lini E | 1995 | Toxicol Pathol1995，23，3： | 1 |
| 11 | Isotopic signature of nitrate in two contrasting watersheds of brush brook, vermont, USA显示文摘 | HALES H C ROSS D S LINI A | 2007 | Biogeochemistry2007，84，1： | 1 |
| 12 | Millennial-scale storminess variability in the northeastern United States during the Holocene显示文摘 | Noren A J Bierman P R Steig E J Lini A Southon J A | 2002 | Nature2002，419，： | 1 |
| 13 | 10000 yr record of extreme hydrologic events显示文摘 | Brown S L Bierman P R Lini A | 2000 | Geology2000，28，4： | 1 |
| 14 | Correlation of early Cretaceous carbon isotope stratigraphy and platform drowning events: A possible link显示文摘 | Weissert H Lini A Folllmi K B | 1998 | Palaeogeography Palaeoclimology Palaeecolology1998，137，： | 1 |
| 15 | Two-fluid model of wavy separated two-phase flow显示文摘 | LINI~ A LOPEZ D | 1997 | International Journal of Multiphase Flow1997，23，6： | 1 |
| 16 | Do cyanobacteria dominate in eu-trophic lakes because they fix atmospheric nitrogen?显示文摘 | Ferber L R Levine S N Lini A | 2004 | Freshwater Bi-ology2004，49，： | 1 |
| 17 | Use of a high affinity DNA ligand in flow cytometry 显示文摘 | LinY Abrams B | 1998 | Nucleic Acid Res1998，26，16： | 1 |
| 18 | Delta (super18)O,delta D and (super 3)H measurements constrain groundwater recharge patterns in an upland fractured bedrock aquifer,Vermont,USA显示文摘 | Lini A Bierman P R | 2000 | Journal of Hydrology2000，228，12： | 1 |
| 19 | THE DENDROCLIMATOLOGICAL POTENTIAL OF AN ALPINE SHRUB, CASSIOPE MERTENSIANA , FROM MOUNT RAINIER, WA, USA显示文摘 | SHELLY A RAYBACK ANDREA LINI DAVID L BERG | 2012 | Geografiska Annaler: Series A Physical Geography2012，，3： | 1 |
| 20 | Do cyanobacteriadominate in eutrophic lakes because they fix atmosphericnitrogen?显示文摘 | FERBER L LEVINE S LINI A | 2004 | Freshwater Biology2004，49，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员