|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Global cancer statistics, 2012显示文摘 | Lindsey A. Torre Freddie Bray Rebecca L. Siegel Jacques Ferlay Joannie Lortet‐Tieulent Ahmedin Jemal | 2015 | CA: A Cancer Journal for Clinicians2015，，2： | 53 |
| 2 | Apoptosis and the target genes of microRNA-21显示文摘MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis.This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21. | Lindsey E.Becker Buscaglia | 2011 | Chinese Journal of Cancer2011，30，6： | 49 |
| 3 | Epstein-Barr virus infection mechanisms显示文摘Epstein-Barr virus(EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cells in vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cell, the players known to be involved in these events, and the ways in which these players are thought to function. | Liudmila S.Chesnokova Lindsey M.Hutt-Fletcher | 2014 | Chinese Journal of Cancer2014，33，11： | 10 |
| 4 | Crosstalk Complexities between Auxin, Cytokinin, and Ethylene in Arabidopsis Root Development: From Experiments to Systems Modeling, and Back Again显示文摘理解荷尔蒙和基因怎么交往在变化环境协调植物生长是在植物的主要挑战发展生物学。植物生长素,细胞激动素,和乙烯是调整植物开发的许多方面的三重要荷尔蒙。这评论极其在 Arabidopsis 根开发评估在三荷尔蒙之间的串音。我们把许多试验性的数据集成到一个串音网络,它在植物生长素,细胞激动素,和乙烯串音揭示复杂性的多重层。特别地,数据集成揭示在乙烯和细胞激动素小径之间的一个另外的、大部分俯看的连接,它通过 phosphorelay 机制行动。这个建议连接探讨乙烯申请是否支持或禁止乙烯受体的受体 kinase 活动的突出的问题。阐明在植物生长素,细胞激动素,和乙烯串音的复杂性要求一联合试验性并且系统建模途径。我们为证实在植物生长素,细胞激动素,和乙烯之间的串音怎么在根开发调整 patterning 评估重要当模特儿的努力。我们讨论反复地把实验与为分析建模的系统相结合的新奇方法论怎么为阐明是必要的在在根开发的植物生长素,细胞激动素,和乙烯的串音的复杂性。最后,我们讨论未来挑战从一联合试验性、建模的观点。 | Junli Liu Simon Moore Chunli Chen Keith Lindsey | 2017 | Molecular Plant2017，10，12： | 8 |
| 5 | Suppression of the homeobox gene HDTF_1 enhances resistance to Verticillium dahliae and Botrytis cinerea in cotton显示文摘Development of pathogen-resistant crops, such as fungus-resistant cotton, has significantly reduced chemical application and improved crop yield and quality. However, the mechanism of resistance to cotton pathogens such as Verticillium dahliae is still poorly understood. In this study,we characterized a cotton gene(HDTF1) that was isolated following transcriptome profiling during the resistance response of cotton to V. dahliae. HDTF1 putatively encodes a homeodomain transcription factor, and its expression was found to be down-regulated in cotton upon inoculation with V. dahliae and Botrytis cinerea. To characterise the involvement of HDTF1 in the response to these pathogens, we used virusinduced gene silencing(VIGS) to generate HDTF1-silenced cotton. VIGS reduction in HDTF1 expression significantly enhanced cotton plant resistance to both pathogens. HDTF1 silencing resulted in activation of jasmonic acid(JA)-mediated signaling and JA accumulation. However, the silenced plants were not altered in the accumulation of salicylic acid(SA) or the expression of marker genes associated with SA signaling. These results suggest that HDTF1 is a negative regulator of the JA pathway, and resistance to V. dahliae and B. cinerea can be engineered by activation of JA signaling. | Wei Gao Lu Long Li Xu Keith Lindsey Xianlong Zhang Longfu Zhu | 2016 | Journal of Integrative Plant Biology2016，58，5： | 5 |
| 6 | Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length显示文摘AIM To analyze how various implants placement variables affect sacroiliac(SI) joint range of motion. METHODS An experimentally validated finite element model of the lumbar spine and pelvis was used to simulate a fusion of the SI joint using various placement configurations of triangular implants(iF use Implant System~?). Placement configurations were varied by changing implant orientation, superior implant length, and number of implants. The range of motion of the SI joint was calculated using a constant moment of 10 N-m with a follower load of 400 N. The changes in motion were compared between the treatment groups to assess how the different variables affected the overall motion of the SI joint. RESULTS Transarticular placement of 3 implants with superior implants that end in the middle of the sacrum resulted in the greatest reduction in range of motion(flexion/extension = 73%, lateral bending = 42%, axial rotation = 72%). The range of motions of the SI joints were reduced with use of transarticular orientation(9%-18%) when compared with an inline orientation. The use of a superior implant that ended mid-sacrum resulted in median reductions of(8%-14%) when compared with a superior implant that ended in the middle of the ala. Reducing the number of implants, resulted in increased SI joint range of motions for the 1 and 2 implant models of 29%-133% and 2%-39%, respectively,when compared with the 3 implant model.CONCLUSION Using a validated finite element model we demonstrated that placement of 3 implants across the SI joint using a transarticular orientation with superior implant reaching the sacral midline resulted in the most stable construct. Additional clinical studies may be required to confirm these results. | Derek P Lindsey Ali Kiapour Scott A Yerby Vijay K Goel | 2018 | World Journal of Orthopedics2018，9，3： | 3 |
| 7 | 成人直肠脱垂、直肠内套叠、直肠前膨出及阴道肠疝的评估与处理显示文摘直肠脱垂是指直肠全层肠壁突出于肛缘。直肠内脱垂或称直肠内套叠的定义为直肠全层肠壁脱垂但并没有突出于肛门外。直肠脱垂和内套叠常常与直肠前膨出(直肠阴道隔向前方疝人阴道)和阴道肠疝(直肠阴道腹膜形成深疝)同时存在。总地来说,这些问题常统称作“盆底功能障碍”。本综述的重点是后盆腔,即直肠,上述疾病均绕其发生。 | Oliver M Jones Christopher Cunningham Ian Lindsey 苏万春(译) 陈雷(校) | 2011 | 英国医学杂志中文版2011，14，3： | 3 |
| 8 | Treatment of hypogonadotropic male hypogonadism: Case-based scenarios显示文摘The aim of this study is to review four case-based scenarios regarding the treatment of symptomatic hypogonadism in men. The article is designed as a review of published literature. We conducted a Pub Med literature search for the time period of 1989-2014, concentrating on 26 studies investigating the efficacy of various therapeutic options on semen analysis, pregnancy outcomes, time to recovery of spermatogenesis, as well as serum and intratesticular testosterone levels. Our results demonstrated that exogenous testosterone suppresses intratesticular testosterone production, which is an absolute prerequisite for normal spermatogenesis. Cessation of exogenous testosterone should be recommended for men desiring to maintain their fertility. Therapies that protect the testis involve human chorionic gonadotropin(h CG) therapy or selective estrogen receptor modulators(SERMs), but may also include low dose h CG with exogenous testosterone. Off-label use of SERMs, such as clomiphene citrate, are effective for maintaining testosterone production long-term and offer the convenience of representing a safe, oral therapy. At present, routine use of aromatase inhibitors is not recommended based on a lack of longterm data. We concluded that exogenous testosterone supplementation decreases sperm production. It was determined that clomiphene citrate is a safe and effective therapy for men who desire to maintain fertility. Although less frequently used in the general population, h CG therapy with or without testosterone supplementation represents an alternative treatment. | Lindsey E Crosnoe-Shipley Osama O Elkelany Cyrus D Rahnema Edward D Kim | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 9 | MicroRNAs in NF-κB signaling显示文摘Nuclear factor κB(NF-κB)is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity,cell proliferation,inflammation,and tumor development.MicroRNAs(miRNAs)are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3′untranslated regions of mRNAs.In this work,we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases,particularly in cancer.The function of miR-146,miR-155,miR-181b,miR-21,and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed.Given that over 1000 human miRNAs have been identified,rendering miRNAs one of the most abundant classes of regulatory molecules,deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer. | Xiaodong Ma Lindsey E.Becker Buscaglia Juanita R.Barker Yong Li | 2011 | Journal of Molecular Cell Biology2011，3，3： | 3 |
| 10 | Microsurgical vasovasostomy显示文摘多达 6 %经历了的人,输精管切除术将最终为各种各样的原因为在 vasovasostomy 或 vasoepididymostomy 形式的颠倒选。执行重获富饶的 Vasovasostomy 是在最后世纪期间经历了众多的进展的一种技术,包括构造过细的吻合的 microsurgical 设备和原则的使用。保证好血供应到吻合以及作为没有紧张的吻合造在 vasovasostomy 期间是重要的。象纸巾的防止损伤的处理一样保证健康 mucosa 和内部 muscularis 的视觉检查是有用的。与 vasovasostomy,创造不透水的吻合阻止第二等的疤形成是必要的。vasovasostomy 的微粒的技术允许更精确要召集的显著地差异的腔。从而,计划与缝术放置被分开,它阻止书页之摺角并且避免随后的漏缝。在年龄在 vitro 授精(IVF )/intracytoplasmic 精子注射(ICSI ) ,在输精管切除术颠倒以后澄清结果,,变得甚至更重要病人们现在把在外科的精子检索之间的一种选择结合 IVF/ICSI 对输精管切除术颠倒。为输精管切除术颠倒的长期的结果上的很少数据存在。因此,这块地里的进一步的研究需要近来评估率失败和预言者近来失败。 | Lindsey Herrel Wayland Hsiao | 2013 | Asian Journal of Andrology2013，15，1： | 3 |
| 11 | Advances in human stem cell therapies:pre-clinical studies and the outlook for central nervous system regeneration显示文摘Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings.There are several types of stem cells currently being used for pre-clinical regenerative therapies,each with unique characteristics,benefits and limitations.This brief review will focus on recent basic science advancements made with embryonic stem cells and induced pluripotent stem cells.Both embryonic stem cells and induced pluripotent stem cells provide platforms for new neurons to replace dead and/or dying cells following injury.Due to their capacity for reprogramming and differentiation into any neuronal type,research in preclinical rodent models has shown that embryonic stem cells and induced pluripotent stem cells can integrate,survive and form connections in the nervous system similar to de novo cells.Going forward however,there are some limitations to consider with the use of either stem cell type.Ethically,embryonic stem cells are not an ideal source of cells,genetically,induced pluripotent stem cells are not ideal in terms of personalized treatment for those with certain genetic diseases the latter of which may guide regenerative medicine away from personalized stem cell based therapies and into optimized stem cell banks.Nonetheless,the potential of these stem cells in central nervous system regenerative therapy is only beginning to be appreciated.For example,through genetic modification,stem cells serve as ideal platforms to reintroduce missing or downregulated molecules into the nervous system to further induce regenerative growth.In this review,we highlight the limitations of stem cell based therapies whilst discussing some of the means of overcoming these limitations. | Lindsey H.Forbes Melissa R.Andrews | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 12 | Strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)显示文摘The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker.In the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)imaging.We have synthesized potential small molecule radiotracers for both the intracellular([18F]InRAGER)and extracellular([18F]RAGER)domains of RAGE.Herein we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)methods.Both radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target binding.The source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains unexplained.We have also investigated use of lipopolysaccharide(LPS)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging agents.Immunoreactivity of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female groups.However,it proves challenging to quantify the changes in RAGE due to off-target binding of the radiotracers.Nevertheless,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNS penetration. | Lindsey R.Drake Allen F.Brooks Jenelle Stauff Phillip S.Sherman Janna Arteaga Robert A.Koeppe Aimee Reed Timothy J.Montavon Marc B.Skaddan Peter J.H.Scott | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 2 |
| 13 | Botulinum Toxin as Second-Line Therapy for Chronic Anal Fissure Failing 0.2 Percent Glyceryl Trinitrate显示文摘 | Ian Lindsey F.R.A.C.S. Oliver M. Jones F.R.C.S. Chris Cunningham M.D. F.R.C.S. Bruce D. George M.S. F.R.C.S. Neil J. M. Mortensen M.D. F.R.C.S | 2003 | Diseases of the Colon & Rectum2003，，3： | 2 |
| 14 | Endoscopic Ultrasound and Computed Tomography Predictors of Pancreatic Cancer Resectability显示文摘 | Philip Q. Bao J. Chad Johnson Elizabeth H. Lindsey David A. Schwartz Ron C. Arildsen Ewa Grzeszczak Alexander A. Parikh Nipun B. Merchant | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 15 | Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction显示文摘 | Anna Zampetaki Peter Willeit Lindsey Tilling Ignat Drozdov Marianna Prokopi Jean-Marie Renard Agnes Mayr Siegfried Weger Georg Schett Ajay Shah Chantal M. Boulanger Johann Willeit Philip J. Chowienczyk Stefan Kiechl Manuel Mayr | 2012 | Journal of the American College of Cardiology2012，，： | 2 |
| 16 | 在全直肠系膜切除术中Denonvilliers筋膜位于固有筋膜层和直肠切除平面之前 | Lindsey I. Warren B.F. Mortensen N.J. 郝筱倩 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，10： | 2 |
| 17 | Consensus on ventral rectopexy: report of a panel of experts显示文摘 | M. A. Mercer‐Jones A. D’Hoore A. R. Dixon P. Lehur I. Lindsey A. Mellgren A. R. L. Stevenson | 2014 | Colorectal Dis2014，，2： | 2 |
| 18 | Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease显示文摘Objective:To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease(AERD)following endoscopic sinus surgery and subsequent aspirin desensitization.Methods:Electronic searches of OVID MEDLINE(1948 to September 10,2019),EMBASE(1980 to September 10,2019),and PubMed were performed on September 10,2019.A systematic review of the literature was performed using the 2009 PRISMA guidelines.Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion.Publications were written in English and included patients aged 18 years or older.Results:Six studies met inclusion criteria for this systematic review.The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores.The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery,with sustained improvement following aspirin desensitization.Revision surgery rates were significantly lower in patients maintained on aspirin therapy.Conclusion:This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures.The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores.Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is inter-rupted. | Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 2 |
| 19 | Will dietary omega-3 fatty acids change the composition of human milk ?显示文摘 | Harris WS Conner WE Lindsey S | 1984 | Am J Clin Nutr1984，40，： | 2 |
| 20 | Hepatitis B Virus Reactivation following Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Sarah P. Hammond Anne Marie Borchelt Chinweike Ukomadu Vincent T. Ho Lindsey R. Baden Francisco M. Marty | 2009 | Biology of Blood and Marrow Transplantation2009，，9： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员