|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 新鲜颞骨模型建立在中耳传声机制研究中的作用显示文摘目的探讨中耳传声机制研究中的中耳模型建立,为深入研究中耳传声机制,指导耳外科手术,尤其在听骨链重建方面建立一个接近活体情况的研究模型。方法采用17例新鲜尸体颞骨标本,利用激光多普勒振动仪,在声刺激和不同强度的机械刺激下,研究了鼓膜和镫骨底板的运动。结果鼓膜和镫骨底板的运动与活体测量的数据接近。结论新鲜颞骨标本可以用于不同方面中耳传声机制的研究。在鼓膜脐部的电机械刺激可以模仿声刺激。 | 马芙蓉 Thomas Linder Alex Huber Heidi Felix Anita Pollak | 2005 | 中国耳鼻咽喉头颈外科2005，12，6： | 9 |
| 2 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 3 | Wnt signaling and Loxl2 promote aggressive osteosarcoma显示文摘Osteosarcoma(OS)is the most frequent primary malignant bone tumor in urgent need of better therapies.Using genetically modified mouse models(GEMMs),we demonstrate that Wnt signaling promotes c-Fos-induced OS formation via the actions of the collagen-modifying enzyme Loxl2.c-Fos/AP-1 directly regulates the expression of the Wnt ligands Wnt7b and Wnt9a in OS cells through promoter binding,and Wnt7b and Wnt9a in turn promote Loxl2 expression in murine and human OS cells through the transcription factors Zeb1 and Zeb2.Concordantly,inhibition of Wnt ligand secretion by inactivating the Wnt-less(Wls)gene in osteoblasts in c-Fos GEMMs either early or in a therapeutic setting reduces Loxl2 expression and progression of OS.Wls-deficient osteosarcomas proliferate less,are less mineralized and are enriched in fibroblastic cells surrounded by collagen fibers.Importantly,Loxl2 inhibition using either the pan-Lox inhibitor BAPN or a specific inducible shRNA reduces OS cell proliferation in vitro and decreases tumor growth and lung colonization in murine and human orthotopic OS transplantation models.Finally,OS development is delayed in c-Fos GEMMs treated with BAPN or with specific Loxl2 blocking antibodies.Congruently,a strong correlation between c-FOS,LOXL2 and WNT7B/WNT9A expression is observed in human OS samples,and c-FOS/LOXL2 co-expression correlates with OS aggressiveness and decreased patient survival.Therefore,therapeutic targeting of Wnt and/or Loxl2 should be considered to potentiate the inadequate current treatments for pediatric,recurrent,and metastatic OS. | Kazuhiko Matsuoka Latifa Bakiri Lena I.Wolff Markus Linder Amanda Mikels-Vigdal Ana Patiño-García Fernando Lecanda Christine Hartmann Maria Sibilia Erwin F.Wagner | 2020 | Cell Research2020，30，10： | 5 |
| 4 | 镫骨赝附体与砧骨长脚之间连接状态对声音传导的影响显示文摘目的探讨镫骨赝附体与砧骨长脚间连接程度对声音传导的影响,为镫骨手术寻找理论依据和更好的指导临床工作。方法17例新鲜尸体颞骨标本,在不同强度的机械刺激下,采用激光多普勒振动仪研究镫骨赝附体与砧骨长脚间不同的连接程度对声音传导的影响。结果将镫骨赝附体与砧骨长脚的连接程度,由三位医师分别对内镜和扫描电镜在颞骨标本中采集的镫骨赝附体与砧骨长脚之间连接的图像进行评分,分为紧密连接、松弛连接和未连接,三位医师的评分结果基本一致。分别对上述三种连接程度,在500mV、800mV和1200mV的机械刺激下,用激光多普勒振动仪测试砧骨长脚侧与镫骨赝附体间的振动差距,经过专门的计算机软件处理,换算为声刺激模式,发现紧密连接时,声音的传导在此连接上损失2dB,小于砧镫关节生理性的声损失3dB,松弛连接和未连接对声音的传导在此连接上的损失很大,高达28dB不等,平均为10dB。结论镫骨手术时镫骨赝附体与砧骨长脚连接紧密,声传导损失接近砧镫关节的生理性声传导损失。 | 马芙蓉 Alex Huber Thomas Linder Heidi Felix Anita Pollak | 2006 | 中国耳鼻咽喉头颈外科2006，13，4： | 4 |
| 5 | 慢性分泌性中耳炎行外耳道后壁整块切除后人工耳蜗植入和外耳道后壁重建显示文摘患儿女,4岁,以双耳极重度感音神经性聋合并双耳慢性分泌性中耳炎收入院。患儿1岁时家长发现对爆竹声无反应,在当地医院检查听性脑干反应(auditorybrainstemresponse,ABR)双耳不能引出反应波。双耳佩戴较大功率的助听器半年无效。1个月前感冒。人院检查:双耳鼓膜为琥珀色。声导抗为B型图。ABR检查120dB双耳不能引出波形。40Hz相关电位检查120dB无反应。耳声发射检查显示双耳耳蜗功能重度损害。颞骨CT显示双耳乳突呈气化型,乳突内可见密度增高影,未见骨质破坏。MRI显示内耳未见明显的结构异常,可见耳蜗神经,乳突区可见长T2信号。全身麻醉下行人工耳蜗植入术。开放乳突时,见乳突为气化型,蜂房内可见淡黄色黏性分泌物储留,大量的炎性肉芽组织,触之易出血而影响面隐窝的开放,经开放的面隐窝观察,后鼓室和中鼓室内大量的炎性肉芽组织,镫骨和蜗窗龛周围的肉芽不易清理而又易于出血,加之面隐窝发育较窄,经面隐窝径路很难行耳蜗造孔电极植入手术,遂改由耳道径路。 | 马芙蓉 Thomas Linder 潘涛 | 2007 | 中华耳鼻咽喉头颈外科杂志2007，42，12： | 3 |
| 6 | Covered metal versus plastic stents for malignant common bile duct stenosis: a prospective, randomized, controlled trial 显示文摘 | Claes Soderlund Stefan Linder | 2006 | Gastrointestinal Endoscopy2006，，： | 2 |
| 7 | Complications From Inflammatory Bowel Disease During Pregnancy and Delivery显示文摘 | Gabriella Br?ms Fredrik Granath Marie Linder Olof Stephansson Maria Elmberg Helle Kieler | 2012 | Clinical Gastroenterology and Hepatology2012，，11： | 2 |
| 8 | The power of business models显示文摘 | Scott M. Shafer H. Jeff Smith Jane C. Linder | 2004 | Business Horizons2004，，3： | 2 |
| 9 | 中耳传声过程中砧镫关节声损失的研究显示文摘目的为了研究声音在中耳传递过程中在砧镫关节上的声损失,深入了解中耳传声中的机制和方式,并探讨其意义,为中耳手术中听骨链重建,尤其是为耳硬化手术中镫骨赝复物与砧骨长脚的嵌合的理想程度寻找理论依据。方法本试验研究了17个新鲜颞骨标本。用2个颞骨进行了机械刺激时的磁场矫正。采用激光多普勒振动仪,分别在声刺激和机械刺激下,对15个新鲜颞骨标本进行了研究。首先测量在80dB声刺激(声压级,下同)下镫骨底板的位移,然后在机械刺激条件下得到等同于80dB声刺激的镫骨底板位移以建立试验体系并保证试验体系的准确性。在等同于80dB声刺激的机械刺激条件下,测量10个颞骨标本砧镫关节的声损失。结果在所测量的频率中,砧镫关节上的声损失在3dB以内。结论中耳传声过程中,在砧镫关节上存在着声损失,这种损失是生理性和保护性的。 | 马芙蓉 Thomas Linder Alex Huber Heidi Felix Anita Pollak | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，7： | 2 |
| 10 | Simplified mammalian DNA isolation procedure显示文摘 | Laird PW Zijderveld A Linders K | 1991 | Nucleic Acids Res1991，19，15： | 2 |
| 11 | 吸烟、体重指数和应激生活事件是银屑病的风险因素:意大利病例对照研究 | Naldi L. Chatenoud L. Linder D. 李政霄 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，11： | 2 |
| 12 | 耳硬化症初次及再次锤骨-镫骨底板开窗术治疗效果的分析比较显示文摘目的分析比较耳硬化症初次及再次修正锤骨-镫骨底板开窗术的手术疗效。方法回顾性分析瑞士卢瑟恩州立医院2002年4月至2017年12月连续收治耳硬化症患者,根据是初次行锤骨-镫骨底板开窗术(primary malleostapedotomy,P-MS)或是再次手术行修正的锤骨-镫骨底板开窗术(rivision malleostapedotomy,R-MS),将患者分为初次手术组(P-MS组)和修正手术组(R-MS组),对二者术中所见、术后听力结果进行比较。采用SPSS 23.0软件进行统计学分析。结果共70例患者(73耳)纳入研究。P-MS组35例38耳,男17例、女18例,平均年龄(43.6±10.5)岁;R-MS组35例35耳,男16例、女19例,平均年龄(47.3±10.9)岁;两组之间年龄、性别、手术侧别差异均无统计学意义(P值均>0.05)。除镫骨固定外,P-MS组术中所见主要为砧骨固定(50.0%,19/38),而R-MS组则为假体移位(60.0%,21/35)。500~3000 Hz和500~4000 Hz纯音听阈,R-MS组术后气骨导差(ABG)分别缩小(15.2±13.8)dB和(17.3±14.4)dB,P-MS组术后ABG分别缩小(18.1±8.2)dB和(18.3±8.5)dB,两组间比较,差异均无统计学意义(P值均>0.05)。R-MS组术后ABG明显大于P-MS组[500~3000 Hz:(16.1±11.8)dB比(8.5±5.7)dB;500~4000 Hz:(17.5±11.9)dB比(9.7±6.0)dB;P值均<0.05];R-MS组手术成功率(术后ABG<10 dB)显著低于P-MS组(500~3000 Hz:31.4%比65.8%,χ^2=8.606,P<0.05;500~4000 Hz:22.9%比57.9%,χ^2=9.240,P<0.05),而手术失败率(术后ABG>30 dB)显著高于P-MS组(500~3000 Hz和500~4000 HZ均为11.4%比0,χ^2值均=3.280,P值均<0.05)。两组各有3耳术后出现感音神经性聋(平均骨导听阈升高>10 dB),差异无统计学意义(500~3000 Hz和500~4000 Hz均为8.6%比7.9%,χ^2值均=0.011,P值均>0.05)。R-MS组初次修正手术(R-MS1)后ABG小于20 dB的比例为80.0%(20/25),而二次修正手术(R-MS2)后该比例为37.5%(3/8),二者差异有统计学意义(χ^2=5.18,P<0.05)。结论与初次锤骨-镫骨底板开窗术相比,再次修正手术引起感音神经性聋的风险并没有增加,而且仍能明显提高听力,但效果较初次手术差,失败风险高。二次修正手术效果欠佳,手术需谨慎,可以考虑助听器或其他听觉植入装置。 | 李阳 Schlegel Christoph Linder Thomas | 2020 | 中华耳鼻咽喉头颈外科杂志2020，55，4： | 2 |
| 13 | Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients 显示文摘 | Robbins RA Linder J Stahl MG | 1989 | Am J Med1989，87，： | 1 |
| 14 | The adsorption characteristics of δ-manganese dioxide: a collection of diffuse double layer constants for the adsorption of H^+, Cu^2+, Ni^2+, Zn^2+, Cd^2+ and Pb^2+显示文摘 | Pretorius P J Linder P W | 2001 | Appl Geochem2001，16，： | 1 |
| 15 | Angiostatin fragments in urine from patients with malignant disease显示文摘 | Sten Linder M Linder C Strander H | 1999 | Anticancer Res1999，19，4： | 1 |
| 16 | A new tire model with an application in vehicle dynamics studies显示文摘 | Bakker E Pacejka H B Linder L | 1989 | SAE1989，98，6： | 1 |
| 17 | Evaluation of dignostic criteria for ankylising spnodlyitis显示文摘 | Van der Linder S Valken S Valkenburg HA | 1984 | Arthritis Rheum1984，27，： | 1 |
| 18 | Treatment of adolescents with Hansaplate/headgear:Influence on face in profile and on dentition显示文摘 | Hansson C Skold B Linder S | 1997 | J Orofac Orthop1997，58，： | 1 |
| 19 | Treatment of symptomatic distal common bile duct stenosis secondary to chronic pancreatitis: comparison of single VS multiple simultane- ous stents显示文摘 | CATALANO MF LINDER JD GEORGE S | 2004 | Gastrointest Endose2004，，60： | 1 |
| 20 | Serum ferritin levels in pre-tenn infants after multiple blood transfusions 显示文摘 | Arad I Konijn AM Linder N | 1988 | Am J Perinatol1988，5，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员