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| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | Magnetic response of metamaterialst 100 terahertz显示文摘 | Stefan Linden L Christian E Martin W | 2004 | Science2004，306，5700： | 1 |
| 3 | A Social capital theory of career success 显示文摘 | Seibert S E Kraimer M L Linden R C | 2001 | Academy of Manage- ment Journal2001，44，2： | 1 |
| 4 | Psychological empowerment as a multidimensional construct: a test of construct validity显示文摘 | Kraimer M L Seibert S Linden R C | 1999 | Educational and Psychological Measurement1999，59，： | 1 |
| 5 | Regression of cervical spinalcord compression in a patient with chordoma following treatmentwith cetuximab and gefitinib显示文摘 | Linden 0 Stenberg L Kjell^n E | 2009 | Acta Oncol2009，48，1： | 1 |
| 6 | Property control of expanding thermal plasma deposited textured zinc oxide with focus on thin film solar cell applications显示文摘 | GROENEN R LOFFLER J LINDEN J L | 2005 | Thin Solid Films2005，492，12： | 1 |
| 7 | Face-name association learning in early Alzheimer's disease: A comparison of learning methods and their underlying mechanisms显示文摘 | Bier N Linden MV Gagnon L | 2008 | Neuropsychol Rehabil2008，18，3： | 1 |
| 8 | A Social capital theory of career success显示文摘 | Seibert S E Kraimer M L Linden R C | 2001 | Academy of Management Journal2001，44，2： | 1 |
| 9 | Distress in spouses and patients after treatment for head and neck cancer显示文摘 | Verdonck-De L I Eerenstein S E Van der Linden M H | 2007 | Laryngoscope2007，117，2： | 1 |
| 10 | A prospective,double-blind,randomized,controlled clinical trial comparing standard woundcare with adjunctive hyperbaric oxygen therapy(HBOT)to stan-dard wound care only for the treatment of chronic,non-healing ul-cers of the lower limb in patients with diabetes mellitus:a study pro-tocol 显示文摘 | O'Reilly D Linden R Fedorko L | 2011 | Trials2011，12，： | 1 |
| 11 | The distribution of val-ue in the mobile phone supply chain显示文摘 | DEDRICK J KRAEMER K L LINDEN G | 2011 | Telecommunications Poli-cy2011，35，6： | 1 |
| 12 | 18F-fluoroestradiol显示文摘 | Sundarajan L Linden HM Link JM | 2007 | Semin Nucl Med2007，37，6： | 1 |
| 13 | Production of the gaseous signal molecule hydrogen sulfide in mouse tissues显示文摘 | Linden D R Sha L Mazzone A | 2008 | Journal of Neurochemistry2008，106，4： | 1 |
| 14 | A model for optimal con- strained adaptive testing 显示文摘 | van der Linden W J Reese L M | 1998 | Applied Psychological Meas- urement1998，22，： | 1 |
| 15 | Hepatic steatosis development with four weeks of physical inactivity in previously active,hyperphagic OLETF rats显示文摘 | LINDEN M A MEERS G M RUEBEL M L | 2013 | Am J Physiol Regul Integr Comp Physiol2013，304，9： | 1 |
| 16 | Quantifying bio-mediated ground improvement by ureolysis: a large scale biogrout experiment显示文摘 | VAN PAASSEN L A GHOSE R VAN DER LINDEN T J M | 2010 | Journal of Geotechnical and Geoenvironmental Engineering2010，136，： | 1 |
| 17 | Photocuring kineticstudies of new dental restorative resins based on poly (ethylene glycol) diacrylate and tris isocyanurated 显示文摘 | Nie J Linden L A Rabek J F | 1998 | Die Angewandte Makromolue- kulare Chemine1998，257，： | 1 |
| 18 | Task Interdependence as a Moderator of Relation between Group Control and Performance显示文摘 | Linden R C Wayne S J Bradway L K | 1997 | Human Relation1997，50，2： | 1 |
| 19 | A reappraisal of the photopolymerization kinetics of triethylene glycol di-methacrylate initiated by camphor quinone N, N-di-methyltoluidine for dental purposes 显示文摘 | Nie J Linden L A Rabek J F | 1998 | Acta Polymer1998，49，4： | 1 |
| 20 | Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases显示文摘 | Van Der Linden L Ulferts R Nabuurs SB | 2014 | Antiviral Res2014，103，： | 1 |
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