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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Modeling slow deformation of polygonal particles using DEM显示文摘We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element Method (DEM) when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time. | Andrés A. Pea Pedro G. Lind Hans J. Herrmann | 2008 | Particuology2008，6，6： | 2 |
| 4 | Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘 | Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG | 2000 | JAMA2000，283，： | 1 |
| 5 | Polymorphisms of DNA repair genes and risk of non-small cell lung cancer 显示文摘 | Zienolddiny S Campa D Lind H | 2006 | Carcinogenesis2006，27，： | 1 |
| 6 | Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus,A/Vietnam/1203/04 (H5N1)显示文摘 | Yun N E Linde N S Zacks M A | 2008 | Virology2008，374，1： | 1 |
| 7 | Acupuncture for patients with migraine a randomized controlled trial显示文摘 | Linde K Streng A Jurgens S | 2005 | JAMA2005，293，17： | 1 |
| 8 | SPECT in patients with epilepsia partialis contiua 显示文摘 | Katz A Bose A Lind S J | 1990 | Neurology1990，40，： | 1 |
| 9 | The epidemiology of severe sepsis in children in the United States 显示文摘 | Watson R S Carcillo J A Linde - Zwirble W T | 2003 | Am J Respir Crit Care Med2003，167，5： | 1 |
| 10 | An environmental wide association study(EWAS)approach to the metabolic syndrome显示文摘 | Lind PM Riserus U Salihovic S | 2013 | Environ Int2013，55，： | 1 |
| 11 | Radiological Prediction of Posttraumatic Kyphosis After Thoraeolumbar Fracture显示文摘 | Curl's I Grimm B Linde M | 2016 | The Open Orthopaedics Journal2016，10，1： | 1 |
| 12 | Nanofiltration of Salt Solutions and Landfill Leachate 显示文摘 | Linde K Joensson A S | 1995 | Desalination1995，103，3： | 1 |
| 13 | Slow earthquakes and great earthquakes along the Nankai trough显示文摘 | Linde A T Sacks I S | 2002 | Earth and Planetary Science Letters2002，203，1： | 1 |
| 14 | Acupuncture for patients with migraine:a randomized controlled trial显示文摘 | Linde K Streng A Jurgens S | 2005 | JAMA2005，293，17： | 1 |
| 15 | Clinical effects of biventricular pacing in patients with severe heart failure and chronic atrial fibrillation: results from the Multisite Stimulation in Cardiomyopathy-MUSTIC study group Ⅱ (Abstract) 显示文摘 | Daubert JC Linde C Cazeau S | 2000 | Circulation2000，102，： | 1 |
| 16 | Upregulation of Na^+/ Ca^2+ exchanger and TRPC6 contributes to abnormal Ca^2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats显示文摘 | Zulian A Baryshnikov S G Linde C I | 2010 | Am J Physiol Heart Circ Physiol2010，299，3： | 1 |
| 17 | EFNS guideline on the treatment of tension-type headache- report of an EFNS task force 显示文摘 | Bendtsen L Evers S Linde M | 2010 | Eur J Neurol2010，17，11： | 1 |
| 18 | Interleukin-17 family members and inflammation显示文摘 | Kol s JK Lindén A | | 0，，04： | 1 |
| 19 | The influence of viscoelasticity on the collapse of cavitation bubbles near a rigid boundary 显示文摘 | LIND S PHILLIPS T | 2012 | Theoretical and Computational Fluid Dynamics2012，26，1： | 1 |
| 20 | Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization显示文摘 | Lind D Franken S Kappler J | 2005 | J Neurosci Res2005，79，3： | 1 |
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