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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 3 | WONCA研究论文摘要汇编——抑郁症初级保健心理治疗效果:系统回顾和Meta分析显示文摘目的系统回顾抑郁症患者初级保健心理治疗有效性的现有可查证据,与一般护理或控制组进行对比,并对疗法类型和实施模式进行研究。方法通过检索MEDLINE、Embase、CENTRAL和Psyc INFO数据库,搜集对比成人抑郁症患者初级保健心理治疗与常规治疗或控制组的随机对照试验,检索时间设定为2013年12月之前。至少两人从纳入研究中进行信息提取,并进行误差风险评估。以治疗后抑郁得分作为指标进行随机效果Meta分析。结果总共30项研究符合纳入标准,涉及5 159例患者。与控制组相比,治疗结束时效果(标准平均差异)得分如下:面对面认知行为疗法(CBT)得分为-0.30〔95%CI(-0.48,-0.13)〕,面对面问题解决疗法得分为-0.14〔95%CI(-0.40,0.12)〕,面对面人际心理疗法得分为-0.24〔95%CI(-0.47,-0.02)〕,其他面对面心理干预得分为-0.28〔95%CI(-0.44,-0.12)〕,远程治疗师引导CBT得分为-0.43〔95%CI(-0.62,-0.24)〕,远程治疗师引导问题解决疗法得分为-0.56〔95%CI(-1.57,0.45)〕,自助引导CBT得分为-0.40〔95%CI(-0.69,-0.11)〕,无接触或最低限度接触CBT得分为-0.27〔95%CI(-0.44,-0.10)〕。结论心理疗法在抑郁症患者初级保健中起到有效作用。与需要大量资源的疗法相比,面对面认知行为疗法能够以更少的资源获得相似效果。 | Linde K Sigterman K Kriston L 本刊编辑部 | 2015 | 中国全科医学2015，18，10： | 9 |
| 4 | 一步浸渍合成具有多重孔隙的铸型炭体(英文)显示文摘 以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体是由高度联接的枝状结构单元为骨架构筑而成。与模板硅相比较,此炭体是硅体的正复本。从纳米尺度分析,这种炭体枝状骨架是由分布均匀且相互连接的中孔构成,此中孔及其孔壁对应于模板硅的孔壁及中孔,是多孔硅的负复本。此外构成中孔的炭骨架本体又含有大量炭化过程产生的微孔。因此该法合成的铸型炭具有孔隙高度发达和结构层层嵌套的特点。 | 陆安慧 Jan-Henrik Smtt Mika Lindn Ferdi Schüth | 2003 | 新型炭材料2003，18，4： | 6 |
| 5 | 埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验显示文摘 | Talley NJ Lauritsen K Tunturi-Hihnala H Lind T Moum B Bang C Schulz T Omland TM Delle M Junghard O 钟捷 | 2003 | 中华消化杂志2003，23，1： | 6 |
| 6 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 7 | 有症状的胃食管反流病中埃索美拉唑抑酸能力比奥美拉唑更强显示文摘 | Lind T Rydberg L Kyreback A Jonsson A Andersson T Hasselgren G Holmberg J Rohss K 钟捷 | 2002 | 中华消化杂志2002，22，9： | 6 |
| 8 | MECHANISM AND KINETICS OF TRANSFORMATION OF ALUMINA INCLUSIONS BY CALCIUM TREATMENT显示文摘当钙介绍了进用电报喂的钢或粉末注射时,在钢的氧化铝包括的转变过程的基本机制和动力学被报导。到机制建模的 clarify,实验被学习在艾尔 2 在一个实验室炉子并且由为艾尔 deoxidised 在一个 8kg 正式就职炉子执行钙处理的 O 3 和 CaO 融化。在在艾尔 2 O 3和 CaO 被 SEMedition 检验(扫描电子显微镜精力散分光计),并且艾尔 2 O 3 CA 6 CA 2 CACA x (l)以试验性的观察被讨论。有氧化铝包括的钙的反应的动力学被在 Ca 沉浸氧化铝盘子模仿对待的钢融化在正式就职炉子。结果与真实包括转变的观察相比。一个运动模型基于结果被建议。 | Z.J. Han L. Liu M. Lind L. Holappa | 2006 | Acta Metallurgica Sinica(English Letters)2006，19，1： | 6 |
| 9 | Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes显示文摘Objective:To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica(M.indica) and Mucuna urens(M.urens) seeds extracts against some key enzymes(-amylase,-glucosidasc and aldose reductase) implicated in the pathology and complications of type 2 diabetes in vitro.Methods:Reverse phase chromatographic quantification of the major flavonoids and phenolic acids in the seeds extracts was carried out using high performance liquid chromatography coupled with diode array detection.The inhibitory activities of the seeds extracts against-amylase and-glucosidase were estimated using soluble starch and p-nitrophenylglucopyranosidc as their respective substrates.Inhibition of aldose reductase activity by the extracts was assayed using partially purified lens homogenate of normal male rat as source of enzyme;inhibition of Fe^(2+)-induced lipid peroxidation by extracts was tested in rat pancreas homogenate.Results:The chromatography result revealed that extracts of both seeds had appreciable levels of some major flavonoids and phenolic acids of pharmacological importance,including gallic acid,chlorogenic acid,caffeic acid,ellagic acid,catechin,rutin,quercitrin.quercetin and kaempferol.Extracts of both seeds effectively inhibited-amylase,-glucosidase and aldose reductase activities in a dose-dependent manner,having inhibitory preference for these enzymes in the order of aldose reductase>-glucosidase>-amylase.With lower half-maximal inhibitory concentrations(IC50)against-amylase,-glucosidase,and aldose reductase,M.indica had stronger inhibitory potency against these enzymes than M.urens.Extracts of both seeds also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,with M.indica being more potent than M.urens.Conclusions:The results obtained provide support for a possible use of M.indica and M.urens seeds in managing hyperglycemia and preventing the complications associated with it in type 2diabetes. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Afolabi Akintunde Akindahunsi Aline Augusti Boligon Margareth Linde Athayde | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，11： | 4 |
| 10 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 11 | 雏鸡成功运输的关键问题显示文摘家禽的健康和生产力在不同生产环境中会表现出较大的变化。了解可导致这种差异的条件及其影响,有助于协调为获得更佳生产性能的支出。良好的开端必不可少,易受攻击的1日龄雏鸡对这些复杂条件的反应会有所不同。繁殖包括遗传和育种;种蛋包括重量、贮存时间和胚胎所处发育状态,因此每一个标明的因子是一个组合体。 | 王晶晶(译) 邹建忠(校) 靳文广(制图表) Gerrit van der Linde | 2016 | 国外畜牧学(猪与禽)2016，36，9： | 4 |
| 12 | 颈椎正常关节活动度显示文摘近四十年来人们对颈椎的活动进行了深入广泛的研究,有些是在尸体解剖标本上进行,大多数是在活体上进行的。常规方法是X 线拍片,但具体方法各异。亦有人用X 线电影照相术,能更精确地描述脊椎活动的类型。但目前尚无人进行不同年龄的大样本的调查研究。本文的目的在于对不同性别、年龄的正常人群的颈椎活动进行群体研究,以期发现一种较运用常规X 线拍片法更实用的检查方法。 | Lind B 周成明 | 1990 | 国外医学(物理医学与康复学分册)1990，10，3： | 3 |
| 13 | Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro显示文摘The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in vitro.Phenolics(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric methods.The extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to health.The extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent manner.The half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(P<0.05),and were in the order of liver>kidney>lungs.The extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>kidney.T.tetraptera fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola Aline Augusti Boligon Margareth Linde Athayde | 2016 | Food Science and Human Wellness2016，5，1： | 3 |
| 14 | Alendronate treatment does not inhibit bone formation within biphasic calcium phosphate ceramics in posterolateral spinal fusion: an experimental study in porcine model显示文摘背景 Biphasic 钙磷酸盐(BCP ) 陶艺作为一个 osteoconductive 矩阵有一个潜在的优点并且让最佳的再吞为骨头形成评价。在针的熔化期间把 BCP 陶艺用作骨头接枝要求在材料并且提供长期的 support.Bisphosphonates 的在邻近的 vertebraes 之间的随后的衔接以内的成骨被报导了延长骨头愈合的过程。在在未知的针的熔化遗体的 BCP 陶艺以内的骨头形成上的 bisphosphonate 治疗的影响。这研究的目的是在 posterolateral 在 BCP 成骨上评估 alendronate 的影响针的有小花梗螺丝钉固定的 fusion.Methods Posterolateral 针的熔化在 22 pigs.BCP 陶艺在腰部的脊骨被执行作为骨头接枝被使用获得在邻近的横向的过程之间的骨头熔化。在处理的十一头猪组织 receivedoral alendronate 为三个月的 10 mg/d 手术后地。在控制组的十一头猪没与 alendronate 接受处理。所有动物经历了 posterolateral 有 BCP 陶艺的针的熔化。熔化率被评估在熔化率由 X 光检查评估了的 operation.Results 以后的三个月在处理组是 27.3% , 20% 在控制组织。用组织学的评估的熔化率在处理组是 18.2% , 20% 在控制组织。熔化质量的吝啬的体积是(3.64 敩 ? 景戠敲獡 ? 慣据牥愠摮搠瑥牥業楮杮琠敨漠瑰浩污琠敲瑡敭瑮趸 ? 趸吗?? | XUE Qing-yun JI Quan LI Hai-sheng ZOU Xue-nong Niels Egund Martin Lind Finn B Christensen Cody Bringer | 2009 | Chinese Medical Journal2009，，22： | 3 |
| 15 | A seroepidemiological study of Mycoplasma pneumoniae infections in Denmark over the 50-year period 1946–1995显示文摘 | K. Lind M. W. Benzon Skov Jensen W. A. Clyde | 1997 | European Journal of Epidemiology1997，，5： | 3 |
| 16 | 制浆造纸行业的可持续性和能源效率提升显示文摘可持续发展一词在1987年联合国世界环境与发展委员会题为《我们共同的未来》的报告中定义为"一种既满足当代人需求又不损害后代人需求的发展模式"。2000年《联合国千年宣言》中明确了可持续发展的原则和约定,即包含:经济发展、社会发展和环境保护[1,2]。可持续性不应只作为一个与生物环境体系相关的概念;相反,应该具有诸如全球责任的经济、社会和生态因素等更多内涵和外延。 | Tom Lind 韩妍燕 谢雁南 Nicholas Oksanen | 2015 | 中华纸业2015，36，7： | 3 |
| 17 | Interleukin-17 Family Members and Inflammation显示文摘 | Jay K. Kolls Anders Lindén | 2004 | Immunity2004，，4： | 3 |
| 18 | In the name of the rose:a roadmap for rose research in the genome era显示文摘The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting activities.Next to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in polyploids.Rose cultivars are highly heterogeneous and diverse.This vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical breeders.We can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding community.This paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be addressed.We outline possible approaches for a number of these questions. | Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher | 2019 | Horticulture Research2019，6，1： | 2 |
| 19 | Prevalence of Barrett’s Esophagus in the General Population: An Endoscopic Study显示文摘 | Jukka Ronkainen Pertti Aro Tom Storskrubb Sven–Erik Johansson Tore Lind Elisabeth Bolling–Sternevald Michael Vieth Manfred Stolte Nicholas J. Talley Lars Agréus | 2005 | Gastroenterology2005，，： | 2 |
| 20 | Modeling slow deformation of polygonal particles using DEM显示文摘We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element Method (DEM) when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time. | Andrés A. Pea Pedro G. Lind Hans J. Herrmann | 2008 | Particuology2008，6，6： | 2 |
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